Nature of the disease
Celiac disease is a fairly common disease but is not very well known. Celiac disease, or celiac sprue, is a digestive condition triggered by consumption of the protein gluten (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011). Gluten is a protein found in wheat, barley, rye, and oats. People with celiac disease who eat foods containing gluten experience an immune reaction in their small intestines, causing damage to the inner surface of the small intestine and an inability to absorb certain nutrients (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011).
The small intestine is responsible for absorbing food and nutrients. Thus, damage to the lining of the small intestines can lead to difficulty absorbing important nutrients; this problem is referred to as malabsorption. Although celiac disease cannot be cured, avoiding gluten usually stops the damage to the intestinal lining and the malabsorption that results. In addition, this disease can affect both male and female as well children and adults.
Signs and symptoms
There is no one certain sign or symptom of Celiac disease. The symptoms associated with this disease vary from person to person. This disease is more common in, but not limited to, Caucasian females (Dugdale III, Longstreth, & Zieve, 2010). Celiac can affect a person at any point in their life, even as young as toddlers.
The symptoms of celiac disease in children usually occur when the child is taken off milk and started on solid food (familydoctor.org editorial staff, 2010). Celiac, in children, most readily affects their growth. Such as delayed puberty, poor weight gain, slowed growth and shorter than normal height for t...
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Celiac Disease, also known as gluten intolerance, is an autoimmune disorder and it affects nearly 1 in every 133 people. A protein in wheat known as gliadin causes a person’s immune system to attack its own bowel and digestive system. This protein is also found in other grains such as rye, barley and oats. There are villi in the small intestine whose job is to absorb nutrients from the foods eaten. Since the body is attacking itself it causes the villi to atrophy and it erodes the nutrient absorbing villi, as it actually shortens and flattens the villi. Due to the affect of the gliadin proteins, it can cause irreversible damage to the lining of the small intestines and its villi. This condition seems to be genetic and can be passed down through generations. It was traditionally thought that this condition only affected People of European dissent, but recent studies show that it is also seen in people of Hispanic, Asian and African American dissent as well. There are blood tests that can be done to determine if one has celiac disease which is very helpful. If getting a blood test or an endoscopy done it is very important that gluten is still being consumed so as the see what affects it has on the body. Celiac disease can cause a myriad of other conditions like intestinal lymphoma; osteoporosis; anemia and it can stunt growth in children due to the fact that the body cannot absorb nutrients causing severe malabsorption of essential nutrients and vitamins.
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Celiac Disease was very unknown in the early 2000’s, making it hard for doctors to diagnose. Most people that develop the disease do so during adulthood, but I was born with it. From birth, my immune system would attack the protein found in wheat, rye, malt, oat, and barley; when attacking the protein, the walls of my stomach and intestines were also being damaged. I would have stomach aches and vomit almost every day. Because the doctors had not diagnosed the disease, I continued to eat gluten, and it continued to cause my body to destroy itself.
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Destructive proteins that contain an abundance of proline and glutamine and the amino acid sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro) are involved. The 33-MER, peptides cannot be broken down any further. When gluten is taken into the body, 33-MER stimulates T-cells to produce antibodies, and it triggers an autoimmune response, which slowly (IgA mediated) damages and destroys the surface villi. Furthermore, it reduces the amount of activity and decreases the amount of enzymes in the surface epithelium. Nutrients are not absorbed, so patients become malnourished regardless of the amount of food consumed.
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