Destructive proteins that contain an abundance of proline and glutamine and the amino acid sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro) are involved. The 33-MER, peptides cannot be broken down any further. When gluten is taken into the body, 33-MER stimulates T-cells to produce antibodies, and it triggers an autoimmune response, which slowly (IgA mediated) damages and destroys the surface villi. Furthermore, it reduces the amount of activity and decreases the amount of enzymes in the surface epithelium. Nutrients are not absorbed, so patients become malnourished regardless of the amount of food consumed.
There is a strong family genetic predisposition for this condition, specifically with the Human Leukocyte Antigen (HLA) genes DR3, DQ2 and DQ8. The Caucasian population and people of European descent experience celiac disease. Moreover, women seem to have a higher prevalence than males for this illness. Incidence within the general population is 1 in 3,000 citizens. People from Mediterranean and African ancestries, Jews, and Asian cultures rarely suffer from this disease. Children can also be affected. Patients who suffer from celiac disease may also experience additional autoimmune diseases like arthritis, systemic lupus, sojourn syndrome, down syndrome, intestinal cancer, lactose intolerance, type I diabetes, intestinal insuffici...
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