The amount of methocel K4M, cetyl alcohol and sodium bicarbonate were taken as independent variables and floating lag time, Q12h and t50% were taken as dependent variables. Tablets were prepared by the direct compression method and evaluated for physical properties, swelling, floating lag time, drug release. In vivo floating study also done on statistically optimized formulation in healthy male rabbit.
The duration of floating time were principally >24 hours and floating lag times <29 seconds. FTIR, DSC and diastereomeric ratio of the SOF revealed there was no chemical interaction between drug and polymer. The statistically optimized formulation (SOF) released drug according to zero order kinetics with a fickian diffusion mechanism. The in vivo evaluation of SOF in healthy rabbit showed that the tablet was buoyant in gastric fluid with change in its swelling.
Key words: Box behnken design (BBD), Response surface methodology, Cefuroxime axetil, Gastroretentive drug delivery, Optimization, Independent Variables, Dependent Variables.
Conventional oral dosage forms present no control over drug delivery leading to fluctuations in plasma drug concentration (Dhole et al., 2011). Oral controlled drug delivery is the majority preferable route of drug delivery ...
... middle of paper ...
...rmulation and evaluation of gastroretentive ﬂoating drug delivery system of Oﬂoxacin. Drug. Inv. Today. 3, 7–9.
• Tiwari, A., Patel, G., Virani, V., 2012. The floating drug delivery system and its impact on calcium channel blocker: A review article. Int. J. Pharma. Res. & Dev. 12, 107-131.
• United States Pharmacopoeial Convention., 2010. United States pharmacopoeia and the national formulary (USP 24-NF 19). Philadelphia: National Publishing Inc. 1429.
• Walters, F.H., Qiu, H.C., 1992. The use of a Box–Behnken 3 factor design to study the paper chromatographic-separation of several amino-acid hydroxamates, Anal. Lett. 25, 1131– 1142.
• William, A.P., 2006;. Pencillins Cephalosporins and other β-lactam antibiotics. In: Bruntan LL, Lazo JS, Parker KL., editors. Goodman and Gilman’s: The pharmacologic basis of Therapeutics. 11th Ed, New York: McGraw-Hill. 1128-48.
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Borrelia Burgdorferi Life History: Lyme disease is an infection caused by Borrelia burgdorferi, a spirochete that is found in deer ticks of genus Ixodes. Lyme disease was named in 1977 after arthritis was observed in clusters in children in Lyme, Connecticut. An infected tick can transmit B. burgdorferi to the humans and animals that it bites. If left untreated, the B. burgdorferi can cause a systemic infection by traveling through the bloodstream and establishing itself in various body tissues.... [tags: Medical Health Biology Essays]
844 words (2.4 pages)
- DISCUSSION In the wake of concerns about increasing rates of postoperative endophthalmitis and antibiotic resistance, continuing efforts are made to find the most effective prophylactic method for preventing postoperative infections. Despite this, endophthalmitis continues to be one of the most devastating complications of cataract surgery. Several factors are suggested to be involved in this process, such as the surgical technique, the intraoperative contamination of the anterior chamber and the increasing age of patients undergoing phacoemulsification.... [tags: technique, patients, infections]
1926 words (5.5 pages)
- MATERIAL AND METHODS This prospective randomized controlled clinical trial was conducted from September 2012 to October 2013 and included patients who underwent microincision cataract surgery (MICS) at the Hospital Virgen de los Lirios. The study recruited 60 eyes of 41 patients. Eligible patients were those aged 65 to 80 with senile cataract and no other concomitant disease that would prevent a postoperative best corrected visual acuity (BCVA) of 20/40 or better. Exclusion criteria included history of ocular surgery or trauma, corneal disease, glaucoma, uveitis, vitreous opacities, retinopathy or visual pathway defects.... [tags: study, patient, disease, techniques]
935 words (2.7 pages)
- Introduction Streptococcus pneumoniae is Gram-positive bacteria, which takes spherical shape, normally present in the form of pairs. These bacteria exist naturally in the respiratory tract, but it may become a pathogenic bacteria in the event of increased its density. These bacteria associated with different types of infections, such as pneumonia, chronic middle ear infections, meningitis, bacteremia. Pneumonia is one of the six major causes leads to death in the United States and the first reason of death from infectious diseases (Garibaldi, 1995 ; Niederman, et al 1998 cited in American Thoracic Society, 2001).... [tags: Gram-positive bacteria, ]
1483 words (4.2 pages)
- Digestive: Irritable Bowel Syndrome This disease affects the muscles in the intestines. It can cause gas, abdominal pain, diarrhea and constipation. It usually does not lead to further diseases. Most people can control the symptoms through diet, stress management and medication. Inflammatory Bowel Diseases Inflammatory bowel diseases include Crohn’s disease and ulcerative colitis. It can lead to severe bowel problems, abdominal pain and malnutrition. Crohn’s disease and ulcerative colitis can also be painful and debilitating.... [tags: abdominal pain, diarrhea and constipation]
1036 words (3 pages)
- Crystalloid versus Colloids: Optimizing Fluid Resuscitation Following Trauma Blunt force trauma to the chest cavity can cause tremendous structural damage, resulting in compromised functional integrity to essential organs, such as the heart and the lungs. Because these primary organs facilitate perfusion to the rest of the body, damage can result in massive hypoperfusion leading to shock. Many researchers concur on the subject of fluid resuscitation to abate affects of cardiogenic shock and even death; however, the debate arises when considering types of fluid resuscitative therapy.... [tags: Heart, Cardiology, Cardiac tamponade, Blood]
1548 words (4.4 pages)