Essay on Cefuroxime Axetil

Essay on Cefuroxime Axetil

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The cephalosporin antibiotic cefuroxime axetil is a prodrug primarily absorbed from the upper part of the GIT and degraded in presence of intestinal esterases. The purpose of this investigation was to apply Box behnken response surface methodology for the development of a gastro retentive floating tablets of cefuroxime axetil and to inspect the effect of formulation variables on drug release and the buoyancy properties of the delivery system.
The amount of methocel K4M, cetyl alcohol and sodium bicarbonate were taken as independent variables and floating lag time, Q12h and t50% were taken as dependent variables. Tablets were prepared by the direct compression method and evaluated for physical properties, swelling, floating lag time, drug release. In vivo floating study also done on statistically optimized formulation in healthy male rabbit.
The duration of floating time were principally >24 hours and floating lag times <29 seconds. FTIR, DSC and diastereomeric ratio of the SOF revealed there was no chemical interaction between drug and polymer. The statistically optimized formulation (SOF) released drug according to zero order kinetics with a fickian diffusion mechanism. The in vivo evaluation of SOF in healthy rabbit showed that the tablet was buoyant in gastric fluid with change in its swelling.
Key words: Box behnken design (BBD), Response surface methodology, Cefuroxime axetil, Gastroretentive drug delivery, Optimization, Independent Variables, Dependent Variables.
















1.0. Introduction

Conventional oral dosage forms present no control over drug delivery leading to fluctuations in plasma drug concentration (Dhole et al., 2011). Oral controlled drug delivery is the majority preferable route of drug delivery ...


... middle of paper ...


...rmulation and evaluation of gastroretentive floating drug delivery system of Ofloxacin. Drug. Inv. Today. 3, 7–9.
• Tiwari, A., Patel, G., Virani, V., 2012. The floating drug delivery system and its impact on calcium channel blocker: A review article. Int. J. Pharma. Res. & Dev. 12, 107-131.
• United States Pharmacopoeial Convention., 2010. United States pharmacopoeia and the national formulary (USP 24-NF 19). Philadelphia: National Publishing Inc. 1429.
• Walters, F.H., Qiu, H.C., 1992. The use of a Box–Behnken 3 factor design to study the paper chromatographic-separation of several amino-acid hydroxamates, Anal. Lett. 25, 1131– 1142.
• William, A.P., 2006;. Pencillins Cephalosporins and other β-lactam antibiotics. In: Bruntan LL, Lazo JS, Parker KL., editors. Goodman and Gilman’s: The pharmacologic basis of Therapeutics. 11th Ed, New York: McGraw-Hill. 1128-48.

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