Introduction Breast cancer is one of the most common types of cancer in women and 70 percentage of breast cancer is caused by the over expression of Estrogen receptor (ER). ER represents a viable and important pharmaceutical target against cancer. It is targeted by pharmaceutical agents for hormone replacement in menopausal women and reproductive cancers such as prostate cancer, uterine cancer and breast cancer [1]. ERs are classified into two types, ER alpha and ER beta which belongs to the super family of nuclear receptors. ER alpha and ER beta have similar but not identical structures. Up regulation of ER alpha causes cell proliferation, inhibition of apoptosis, stimulation of invasion and metastasis, and promotion of angiogenesis. While not much is known about ER beta, it is believed that its function is distinct from ER alpha and it probably has opposing activity on tumour growth [2]. Tamoxifen is the drug regularly prescribed for the treatment of breast cancer. The anticancer property of Tamoxifen has been attributed to its anti estrogenic properties. The use of Tamoxifen is limited due to the acquired Tamoxifen resistance in many cancer patients [3]. Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs which have anti inflammatory action and also used for fever (anti pyretic) and pain reduction. Aspirin is the first NSAIDs used for treating human ailments, which is derived from the bark of the willow tree. NSAIDs act as non selective inhibitors of the enzyme cyclooxygenase (COX) causing the reduction of the formation of prostaglandin and thromboxane. NSAIDs have recently received increasing attention as anticancer agents. In vivo studies with NSAIDs have shown the anticancer property of these drugs against breast c... ... middle of paper ... ...han ArgusDock [14-15]. Conclusion Molecular docking was used to explore the binding mechanism and to correlate docking score of NSAIDs with the human estrogen alpha receptor (PDB ID: 3ERT) and estrogen related gamma receptor (PDB ID: 2GPU). In the present study, results show that NSAIDs have a good binding energy values with both the ER proteins. Valdecoxib which was withdrawn from the market had shown the good energy values in the optimized NSAIDs. The antagonist action of NSAIDs towards ER could be one of the possible reasons why NSAIDs have anticancer property; further studies need to be done to confirm these properties .The result of our study can be used for the development of NSAIDs as potential inhibitors for estrogen receptors. Acknowledgment This research is carried out independently, no funding whatsoever received for carrying out this work.
Aspirin contains the substance acetylsalicylic acid (ASA), which can relieve inflammation, fever, pain, and known as a “blood thinner”. Aspirin was not officially trademarked until March 6, 1899 when the Imperial Office of Berlin made it official. It has been used for the last 110 years, but its natural form, salicylic acid has been around for thousands by Egyptians, Greeks, and Romans. Aspirin is available in over 80 countries and known as the best non-prescription drug. The most common use of aspirin is to cure headaches and use it as a pain reliever, but aspirin is known to prevent heart attack and strokes. It was first proposed in 1940, but wasn’t confirmed until 1970 when doctors would recommend taking aspirin daily [1].
..., t. t. (n.d.). Menopausal Hormone Replacement Therapy Use and Cancer - National Cancer Institute. Comprehensive Cancer Information - National Cancer Institute. Retrieved September 19, 2011, from http://www.cancer.gov/cancertopics/factsheet/Risk/menopausal-hormones/print
In 1896 the scientist Beatson reported that the removal of the ovaries resulted in the reduction of breast cancer tumours (Russo and Irma 1998). Breast cancer is a malignant, metastasizing cancer of the mammary gland. It is the leading cause of death in woman between the ages of 35 - 45. Breast cancer can also occur in males, although less frequent, around 400 men die each year from breast cancer in the united states. (Martini, F., 2004). Studies on rats have shown considerable evidence that rat oestrogens are mammary carcinogens. Oestrogens have shown to stimulate the hormone prolactin. Through studies involving the use of antioestrogens, for example, tamoxifen, "Tamoxifen alone or in combination with the retina all trans-N-(4 hydroxyphenyl)-retinamide (4-HPR) reduces the incidence of NMU-induced mammary tumours in Sprague-Dawley rats." (Jane M. Ussher Ph.D. 1996). This suggests that Oestrogens and Prolactin's can have the effect of the development of breast cancer since the pathogenesis of spontaneous breast cancer in humans is similar to that of chemical-induced rodent mammary cancer. (Jane M. Ussher
...ars to be the most promising agent in primary prevention of breast cancer. It changed the way prevention is perceived by biomedicalizing it. Prevention is seen as equivalent to risk reduction. Also, it is the only United States Food and Drug Administration (US FDA) approved drug for reducing breast cancer risk in high-risk women. Promising as it may seem, the scope of primary prevention has been restricted to women at high risk of developing breast cancer because of inherent limitations of these strategies. Knowledge is power, “The lack of knowledge in the realm of breast cancer prevention makes for greater investment in chemoprevention”. Owing to failure of etiologic studies in breast cancer research to identify primary prevention strategies suitable for the general population, reducing mortality through early detection of breast cancer still remains the mainstay.
In response to the question set, I will go into detail of the study, consisting of the background, main hypotheses, as well the aims, procedure and results gathered from the study; explaining the four research methods chosen to investigate, furthering into the three methods actually tested.
Many breast cancers are sensitive to the hormone estrogen. Thus estrogen leads to development of breast cancer tumor formation. Such cancers have cell surface receptors for estrogen. They are called ER-positive cancer or estrogen receptor-positive cancer.
About 12% of women in the United States will develop breast cancer in their lifetime, more than any other type of cancer (www.breastcancer.org, 2015). Many people lack the knowledge of how breast cancer is developed. Some people think they will not get cancer because they do not smoke cigarettes, but this is not the only cause of cancer developing in the breast. Anyone can get cancer. Everyone is potentially at risk for developing some form of Cancer (American Cancer Society, 2015).
A lot of evidence have linked breast cancer to the environmental chemicals. Since WWII, a great deal of endocrine disrupters (synthetic chemicals) have entered the environment, accumulated through the food chain, and finally accessed into human bodies (Brody et al.) . According to Gray et al., environmental chemicals are carcinogenic because they often interrupt hormone-regulated pathways, especially that of the estrogen, and thus cause negative genetic variations. Experiments carried out by Gray et al. indicate that breast tissue synthesize estrogen from local hormone (androgenic hormones) using aromatase, whose activity rate is abnormally higher in breast cancer tissue than that of normal breast tissue. Theoretically, “estrogen promotes the growth cancer cells in vivo” (Mitra et al); the fact that women are more likely to ...
Breast Cancer is defined as “a group of solid tumor malignancies arising in the tissues of the breast” (Sarah Crawford, Richard Alder, 2013) in human and other mammals. It can happen to both men and women. For women, breast cancer is one of the leading causes of cancer death. According to National Cancer Institute, in the United States, the 2014 estimated new cases and deaths of female from breast cancer are 232,670 and 40,000, respectively. For male, it’s 430 deaths out of 2,360 new cases. From these numbers, we can see that women in the U.S. are greatly affected by breast cancer, thus, it’s not difficult to imagine the impact on a worldwide level. Although these numbers look frightening, people can actually survive from breast cancer if it is detected early and treated properly, so it is extremely important for all of us, especially women, to have a better understanding of breast cancer.
CONTENTS PAGE Content Page Abstract Introduction Method Results Conclusion & Discussions Evaluation- Variability Analysis - Limitations & Errors
The authors of this article have outlined the purpose, aims, and objectives of the study. It also provides the methods used which is quantitative approach to collect the data, the results, conclusion of the study. It is important that the author should present the essential components of the study in the abstract because the abstract may be the only section that is read by readers to decide if the study is useful or not or to continue reading (Coughlan, Cronin, and Ryan, 2007; Ingham-Broomfield, 2008 p.104; Stockhausen and Conrick, 2002; Nieswiadomy, 2008 p.380).
Background Information Aspirin is an analgesic (pain relieving) and an antipyretic drug (a drug that lowers body temperature). The main constituent of aspirin is 2 - ethanoythydroxybenzoic acid, also known as acetylsalicyclic acid (shown below right). It was originally made from just salicylic acid (which is found in the bark of a willow tree) when used by the Ancient Greeks to counter fever and pain, but its bitterness and tendency to irritate the stomach caused problems. These were resolved by the German chemist Felix Hoffman, who made the acetyl derivative of salicylic acid in the
Breast Cancer is on the forefront of modern tumor research and scientists are continually seeking new ways to treat and prevent cancer progression. Current treatments using hormone-dependent drugs like Tamoxifen and Raloxifene focus on estrogen receptor inhibition in mammary and endometrial cell lines. The estrogen receptor is heavily targeted in breast cancer treatment because it is easy to inhibit has strong affinity for binding to many molecules mimicking the estrogen hormone - inducing cell proliferation in the breast and endometrium. Estrogen receptor drugs are known as selective-estrogen receptor modulators or SERMS, which are effective in estrogen-receptor positive (ER+) and hormone-estrogen receptor 2 positive (HER2+)
Uterine cancer is an important women health problem developing rapidly, killing over 200,000 women each year. No one has discovered the actual cause, but there is a leading factor that has great suspicions to what is causing this cancer to grow rapidly.
Molecular pharmacology deals with the biochemical and biophysical characteristics of interactions between molecules of different substances and those of the cell. In other words, it is molecular biology applied to pharmacologic and toxicologic questions. The methods of molecular pharmacology include precise mathematical, physical, chemical and molecular biological techniques to understand how cells respond to hormones or pharmacologic agents, and how chemical structure correlates with biological activity of various