Introduction
There are a lot of important details and information healthcare provider should know about patient before performing any procedure or prescribing drug. One of such piece of information is a blood type. First blood groups were discovered by Karl Landsteiner in 1901. Landsteiner was researching the fact that some blood transfusions were successful and other could be potentially lethal. He made a research where he demonstrated that the serum from one people lead to agglutination of blood cells from other in some cases, but in others agglutination did not occur. In his experiments he discovered first three types of blood A, B and O. Later Landsteiner and American researcher Alexander Wiener discovered new blood type Rh, which was reported in 1940, 1941. (Farhud, 2013)
Blood type is defined by presence or absence of certain antigens on surface of red blood cells (RBCs) named antigens A, B, O or Rh (D). Depending on which antigen is present on plasma membrane of RBCs person will have certain antibodies present in plasma. Blood type A has antibodies for type B blood. Type B blood has anti-A antibodies, and type O blood has anti A and B antibodies. Knowing information about blood type of patient is extremely important during blood transfusion because antibodies for certain blood type attack antigens present on RBC of foreign blood causing agglutination - clumping of RBCs. So blood cells with antigen A on their surface membrane will be affected by antibodies A, RBCs with antigen B will react with antibodies B and RBCs with antigen Rh will react with Rh antibodies. If recipient with type A will be given blood which contains antibodies A (types B and O) agglutination will occur and lethal outcome is possible. It is important t...
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...oncluded to be AB+. Table 2 summarizes conclusion made in this experiment.
Table 2
Sample 1 Sample 3 Sample 4 Sample 5
Blood type A+ B+ B- AB+
Overall blood typing techniques were studied during this lab and students became familiar with blood types and the way to identify them. All members of study group followed the procedure in order to avoid cross contamination so the results are considered to be accurate. This lab provided great visualization of agglutination and improved understanding of this process. Overall blood typing has wide application in healthcare setting. Examples can be blood typing done before blood transfusion, during pregnancies or blood typing for research and better understanding of blood related disorders. Such a wide application of these techniques makes them important to study by all students who is going to pursue any career in medicine.
In Blood In Blood Out is a drama directed by Taylor Hackford, and starring Damian Chapa (Miklo), Benjamin Bratt (Paco), and Jesse Borrego (Cruz), produced by Hollywood Pictures. The film was based off everyday life in East Los Angeles, from the 1970’s through the 1980’s. Damian Chapa stars as Miklo in the film, a Mexican-American who wanted to be accepted, not by his skin but for the Mexican within him. Benjamin Bratt (Paco) was the older cousin of Miklo, who learned his lesson throughout the movie and changed his ways. Jesse Borrego (Cruz) is the step-brother of Paco who was a talent artist, who ended up turning to drugs because of back problems caused by a rival gang incident.
Three hundred and thirty-four years later in the future, Carl Landsteiner, a Viennese doctor, performed a very simple experiment with blood in 1901. During his experiment, Landsteiner noticed "clotting in some samples of mixed blood and not others". (Tucker, 10) Landsteiner separated his samples into three groups: A, B, and C, according to how they clotted in his experiment. Today, the blood type C is known as type O blood. When Landsteiner was grouping these blood types, he happened to look over type AB. AB occurs in about 3 percent of the population. Later in 1907, two researchers, Jan Jansky in Czechoslovakia and William Lorenzo Moss in the United
There are different types of bloodstain patterns that give a sense of what happened at the scene. The idea is to get a sort of background story from the random blood distribution. The different types of blood can tell us the method an assailant used such as passive blood stains. These stains are made from the drops off a weapon due to gravity. For instance, if an attacker w...
Racism, a plague in our society that has infected our society, and still does today, has been rooted by the premise of Darwinian evolution. Racism existed long before Charles Darwin made his mark in history; however, in the book One Race One Blood, the authors explain how there is a very close relationship between the theory of evolution and what we know today as racism. The authors intent of this book is to realize the effects of a specific ideas that has shaped racism. Mr. Ken Ham describes ideas as being seeds, “…they might seem small; they might seem insignificant; they might even go unnoticed by all expect those who hold them in the moment…” (7). Charles Darwin’s idea (or seeds) of his evolutionary has taken root and made its way into public schools, the government, and even our churches. Although, racism did not originate with Darwin, Ken Ham claims that, “he did more than any other person to popularize it” (22). His evolutionary ideas have fueled racism and this is what racists use to justify their hatred toward those who are different from them (8).
BioPure Corporation, which was founded in 1984 by entrepreneurs Carl Rausch and David Judelson, is a privately owned biopharmaceutical firm specializing in the ultra purification of proteins for human and veterinary use. In 1998 Biopure pioneered the development of oxygen therapeutics using “Hemoglobin”, a new class of pharmaceuticals that are intravenously administered to deliver oxygen to the body's tissues. Biopure's two products, Hemopure for human use, and Oxyglobin for animal veterinary use, both represented a new Oxygen based treatment approach for managing patients' oxygen requirements in a broad range of potential medical applications. The factor distinguishing Biopure’s two products from other blood substitute products being developed by two possible rivals, Baxter International and Northfeild Laboratories, is that its hemoglobin based source is bovine rather than human and was derived from the blood cells of cattle. Both of Biopure’s blood substitute products were in the final stages of the approval process of the Food and Drug Administration (FDA) in 1998. Oxyglobin had just received the FDA’s approval for commercial release declaring it safe and effective for medical use. Hemopure was entering final Phase 3 clinical trials and was optimistically expected to see final FDA approval for release in 1999. The FDA approval of Oxyglobin and its possible subsequent release into the veterinary market caused concern over whether the early release of Hemoglobin would impinge BioPure’s ability to price Hemopure when the product finally received approval. Given that the two products were almost identical in properties and function, it was thought that the early release of Oxyglobin would create an unrealistic price expectation for Hemopure if released first.
Harmening, D. M. (2005). Modern Blood Banking & Transfusion Practices. Philidelphia, PA: F.A. Davis Company.
Blood types, agglutination, carbohydrates, antigens and antibodies are all used to classify blood in health situations. There are four different types of blood types; type A, type B, type AB, and type O blood. Each of these blood types have specific antigen markers used for identification purposes, except type O, which contains no antigens. They also include antibodies that attack foreign invaders, except type AB, which contains no antibodies. The monosaccharide of each blood cell contains N-acetylglucosamine, galactose, and fructose. Type A, type B, and type AB has additional monosaccharides that differentiates itself from other blood types. Blood types can be determined by using the slide test method or test tube method, in which medical practitioners add antiserums and look for agglutination.
Wallace Terry has collected a wide range of stories told by twenty black Vietnam veterans. The stories are varied based on each experience; from the horrific to the heart breaking and to the glorified image of Vietnam depicted by Hollywood. Wallace Terry does not insinuate his opinion into any of the stories so that the audience can feel as if they are having a conversation with the Vietnam Veteran himself. Terry introduces the purpose of the book by stating, “ Among the 20 men who portray their war and postwar experiences in this book. I sought a representative cross section of the black combat force.”(p. XV) Although the stories in this book were not told in any specific order, many themes became prominent throughout the novel such as religion, social, and health.
Blood doping could have opposite effect of those intended. A large infusion of red blood cells could increase blood thickness and cause a decrease in cardiac output and a reduction in oxygen content. Both would reduce aerobic capacity. The human heart was not designed to pump thickened blood throughout the body and, therefore, it could lead to a multitude of problems. The diseases that can be contracted from autologous blood transfusion are severe. Even more frightening is the list of diseases that can be contracted through homologous blood transfusion. It includes hepatitis, AIDS, malaria, and CMV. In addition, shock is a factor to be aware of.
There are four different types of blood; A, B, AB, and O. This is called the ABO blood typing system. All four different types of blood serve the same purpose of transporting nutrients and oxygen throughout the human body. But what makes them different? Blood typing is based on the presence or absence of A and B cell antigens which trigger antibodies. Each kind of blood has it’s own antibody or immunoglobulin, which are proteins produced by the immune system to help stop intruders from invading your body. Therefore,
Although blood transfusions had been used before the First World War, many were not successful due to lack of knowledge in this type of treatments. World War I pushed the development of blood transfusions, allowing them to be safer. Before the war in the 17th century, blood transfusions often occurred with the use of animal blood, a practice that did not achieve desired results. These transfusions often times came from sheep, and although they were sometimes successful, it was discovered that any large amounts of transfusions would cause death. Coming to the conclusion that animal blood transfusions did not save lives, scientists looked to humans for human to human transfusions. Many of these attempted transfusions were met with failure but in 1818, Dr. James Blundell accomplished the first successful human blood transfusion; four ounces of blood were transferred to the patient from her husband. From that moment on, doctors began to learn even more about blood transfusions and how to do them properly. By 1901, the four human blood groups were discovered by Karl Landsteiner; with less differences in the bloods transfused together, coagulation and clumping amounts decreased. This benefited many lives in that toxic reactions to the wrong types of blood did not occu...
The interest in studying Rhesus disease stems from an aspiration to understand blood and its’ components at a cellular level. In order to recognize what factors lead to this disease and what components of the cell can be used as indicators/markers to diagnose it, one must have a general idea of the concepts involved in cellular processes. This paper will focus on the causes of hemolytic disease, including natural and/or surgical & medicinal occurrences that cause isoimmunization; how antigens and antibodies are involved, and the effectiveness of Rh immunoglobulin will also be considered.
Peschel, O., Kunz, S. N., Rothschild, M. A., & Mützel, E. (2011). Blood stain pattern analysis. Forensic science, medicine, and pathology, 7(3), 257-270. http://link.springer.com/article/10.1007/s12024-010-9198-1
In this experiment, we determined the isotonic and hemolytic molar concentrations of non-penetrating moles for sheep red blood cells and measured the absorbance levels from each concentration. The results concluded that as the concentration increased the absorbance reading increased as well. A higher absorbance signifies higher amounts of intact RBCs. The isotonic molar concentration for NaCl and glucose is 0.3 M. The hemolysis molar concentration for NaCl and glucose is 0.05 M. Adding red blood cells to an isotonic solution, there will be no isotonic pressure and no net movement. The isotonic solution leaves the red blood cells intact. RBC contain hemoglobin which absorbs light, hemoglobin falls to the bottom of the tube and no light is absorbed. Determining the isotonic concentration of NaCl and glucose by finding the lowest molar concentration. In contrast to isotonic molar concentration, hemolysis can be determined by finding the
Blood typing is done prior to a blood transfusion or when classifying a person’s blood for donation. Blood grouping is a fast and secure way to ensure the patient receive the right blood during surgery. Otherwise, the incompatible blood will cause blood clumping or agglutination, which can be fatal.