Bilayer Tablet Technology in Medical Treatment Essay

Bilayer Tablet Technology in Medical Treatment Essay

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An acute or chronic illness for decades is being clinically treated through delivery of drugs in patients in the form of some pharmaceutical dosage forms like tablets, capsules, liquids, creams, pills, aerosols, injectable and suppositories. An ideal drug delivery system is such that it provides the required drug amount with in a short duration and also should maintain the steady level of drug concentration throughout the dosing period [1]. However any conventional dosage form behaves as per its type either immediate release or sustained release. Further the drugs with shorter half lives should be administered multiple times to maintain required drug level and more often, the patient needs to be prescribed multiple drugs at a time to control the symptoms and to restore the physiological system. Different variety of materials and approaches can be utilized in designing and constructions of system that is capable of providing predictable, precise and reproducible pattern of drug release. Controlled drug delivery system has been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms. Greater attention has been focused on development of sustained or controlled release drug delivery systems with recognition of therapeutic advantages of controlled drug delivery[2, 3], however its combination with immediate release in a single dosage form would be advantageous for maintaining patient compliance and effective therapeutic outcome. This can be done by using Bilayer tablets which can also combine more than one drug in a single tablet (Table 1).

Table 1: Comaparison of bilayer tablet with conventional tablet for (i) Multiple drugs (ii) Immediate release and sustained release formulation of s...

... middle of paper ...

...drug used for treatment or management of a disease. Recently, fixed dose combination drugs are becoming increasingly popular, particularly as lifecycle management strategies seeking to extend intellectual property and minimizing generic exposure by creating an innovative dosage form.
A survey of last 12 years patents also reveals that this technology spans almost every therapeutic category especially, antihistaminic, adrenergic, ACE inhibitor, diuretic, antidiabetic, antihypercholesterolemic, antiinflamatory, analgesic, proton pump inhibitors etc. However a study of marketed formulations showed that a combinations of antimalarials, antitussive,antidepressant, antihistaminic, antiasthamiatic, antidiabetic, antimycobacterial, antihypertensive, antibiotic, antispasmodic, analgesic, antiviral are being available in market as representative of bilayer tablet technology.

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