Table 1: Comaparison of bilayer tablet with conventional tablet for (i) Multiple drugs (ii) Immediate release and sustained release formulation of s...
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...drug used for treatment or management of a disease. Recently, fixed dose combination drugs are becoming increasingly popular, particularly as lifecycle management strategies seeking to extend intellectual property and minimizing generic exposure by creating an innovative dosage form.
A survey of last 12 years patents also reveals that this technology spans almost every therapeutic category especially, antihistaminic, adrenergic, ACE inhibitor, diuretic, antidiabetic, antihypercholesterolemic, antiinflamatory, analgesic, proton pump inhibitors etc. However a study of marketed formulations showed that a combinations of antimalarials, antitussive,antidepressant, antihistaminic, antiasthamiatic, antidiabetic, antimycobacterial, antihypertensive, antibiotic, antispasmodic, analgesic, antiviral are being available in market as representative of bilayer tablet technology.
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