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Hepatotoxity is influenced by the depletion of glutathione in the liver. This is because of excessive intake of paracetamol that causes the drug to be oxidized. When there is increased intake of the drug, there are many adverse reactions that inhibit the production of glutathione. This leads to the production of hepapotoxity, one of the adverse effects associated with taking paracetamol (Pharmweb 2011). Hepapotoxity is mainly caused by the buildup of benzoquinoniemine, after complete depletion of glutathione from the liver. The effects are too severe that liver failure may occur.
In the event of an overdose, N-acetylcysteine is administered. This drug causes the liver to restructure itself and take on important tasks and functions. The liver is restored to its original state and this makes it more functional and ready to work on any foreign particles. The liver is restored and this helps in the generation of glutathione that is meant to combine with benzoquinoneimine. Timely use of N-acetylcysteine makes the liver to be safe and positively impacts on its fundamental roles. For this reason, early treatment of paracetamol overdose is recommended (Stoelting & Miller 2000).
Opioids are absorbed at the opioid receptors of the central nervous system. One of the key issues that happen at the receptors is the absorption of the drug at the cellular membranes (Department of Health 2011). The drug alters interchange of stimuli at the cellular membranes and this causes the transmissions at the central nervous system to be altered. This inhibits pain and other feelings, making the patient to appear numb and docile. Morphine mostly reacts with pain reactors and causes the patients to develop adverse effects that prevent pain and other physical feelings (National Center for Biotechnology Information 2011).
Opioid overdose is influenced by the intake of other drugs like alcohol. In the event that a person consumes excessive opioids like morphine or such related drugs, there is a chance of complete numbness that may even lead to death.
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