1. Which antibacterial agent(s) would be effective in the therapy of Mr BT’s urinary tract infection?
Cephalexin and Gentamicin would be effective since they are equally sensitive to the pseudomonas aeruginosa microbe which implies they will kill the microbe and work against the bacteria.
2. State the mechanisms of action of each of these agents.
Cephalexin, is a beta-lactam antibiotic. The antibiotic binds to specific penicillin-binding proteins positioned inside the bacterial cell wall, this inhibits the third and last stage of bacterial cell wall synthesis. The consequences are fatal to the susceptible bacteria but comparatively harmless for the human cells because the latter does not possess such a structure. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin impedes with an autolysin inhibitor. Consequently these antibacterial drugs are bactericidal agents that impede the development of the rigid cell wall of the dividing bacteria (Neal & Michael, 2012).
Gentamicin, is a broad spectrum aminoglycoside antibiotic. Aminoglycosides such as gentamicin "irreversibly" bind to particular 30S-subunit proteins and 16S rRNA. Gentamicin particularly binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This intervenes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This area interacts with the wobble base in the anticodon of tRNA. This leads to interfering with the instigation complex, misinterpretation of mRNA so inaccurate amino acids are introduced into the polypeptide leading to non-functional or toxic peptides and the breakup of polysomes into non-functional monosomes. Gentamicin acts by...
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...be is causing it. Giving the patient a wide-spectrum antibiotics allows the healthcare provider to treat the patient for almost any possibility until they wait for the test results to come back. When the results are receive the healthcare provider can treat the patient more specifically to the microbe (Asperheim & Mary, 2012).
Asperheim, & Mary, K. (2012). Introduction to pharmacology (12th ed.). St.Louis: Elsevier
Bullock, S. & Manias, E. (2011). Fundamentals of pharmacology, (6th ed.). Sydney, Pearson Education Australia.
McKenry, L.M., & Salerno, E. (2006). Mosby’s pharmacology in nursing (22nd ed.). St Louis: Mosby - Year Book, Inc.
Neal, & Michael, J. (2012). Medical pharmacology at glance, (7th ed.). Hoboken: John Wiley & Sons.
Porth, C. (2009). Pathophysiology: Concepts of altered health states (8th ed.). Philadelphia: Lippincott-Raven.
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