In 1988, Yoshinori Ohsumi focused the majority of his time on understanding the machinery behind protein degradation in the vacuole, an organelle that corresponds to the study of the lysosome in human cells. The reason Ohsumi choose yeast cells as the subject for his studies were due to the fact they are fairly easy to study and are often used interchangeably to replicate for human cells. (1)
Consequently, Ohsumi undertook several challenges throughout his studies due to the indistinguishable yeast cell under the microscope, to even doubting if autophagy could exist in a yeast cell. Ohsumi understood that if he could di...
... middle of paper ...
... cancer is so important as it will bring forth current opportunities for drug development as more potent and specific inhibitors of autophagy are needed. The role of autophagy and its management in cancer cells continues to grow and studies aim to define optimal procedures to regulate autophagy for a therapeutic advantage. (7)
To conclude, Yoshinori Ohsumi’s passion for cellular biology and dedication in understanding the mechanisms behind the process of autophagy made him well deserving of the Nobel prize in medicine. Since his discovery, numerous studies have been conducted furthering the knowledge on the central concept and have led to advancements in the understanding of numerous diseases and physiological processes. Ultimately, Ohsumi’s success through his studies has shaped the future of autophagy and led the pathway to a plethora of new discoveries to come.
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