An Analysis Of Variation Of Transcription Factor Binding Sites

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An analysis of variation of transcription factor binding sites in Drosophila and Humans INTRODUCTION This research paper is about “An analysis of variation at transcription factor binding sites in Drosophila and humans”. This analysis is done in order to investigate the transcription factor binding sites variability with the comparison of ready published data of transcription factor binding maps for Drosophila isogenic lines and human individuals. Genome is considered as the encoder or provider of disambiguation for many diseases, viruses, DNA and other organisms. Here it is very important to understand the concept of population genetics. Population genetics explains the study and research of distributions and modifications of allele frequency in a population. It further states that there are actually four evolutionary processes such as; selection, genetic drift, mutation and gene flow. It is important to describe an analysis of the relationship for exploration of intra species variation and it has been seen that variation in DNA regulatory elements are common and TRFs shows a fraction of it. Across 12 Drosophila species have been analyzed in order to see the sequence variation at each motif position. And the results showed that motifs are conserved and depressed level of variation has been shown across individuals. An introduction of Transcription factor binding variability which has been taken into account transforms itself in a sort of motif match related to mutation and enable the researchers to investigate and makes it possible to analyze TFBS related hurdles and operational constraints which shares medical or biological related attributes or characteristics. Another benefit which can be extracted here is by emerging per in... ... middle of paper ... ...e the top with blue and bottom with red curves and contrasted to a simple 6% at the right side, that is the conserved site. Incorporating genome-wide transcription factor binding profiles along with individual deviation information in human and Drosophila, the review illustrates that transcription factor binding sites are inhibited functionally and yet mutations within them are tolerated. It provides evidence for probable buffering effects. Further than biological inferences, provided results have highlighted the prospective of population genetics and incorporating functional genomics approaches for the understanding of the cis-regulatory mechanism. Reference Spivakov, M., Akhtar, J., Kheradpour, P., Beal, K., Girardot, C., & Koscielny, G. et al. (2012). Analysis of variation at transcription factor binding sites in Drosophila and humans. Genome Biol, 13(9), 49.
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