Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease, affects approximately 20,000 - 30,000 U.S. citizens, with an estimated 5,000 new diagnoses made each year. ALS is a rapidly progressive neurological disease which attacks neurons responsible for the control of voluntary muscles, and is habitually fatal. ALS is part of the class of disorders called motor neuron diseases (MNDs). Motor neuron diseases are characterized by the gradual degeneration of motor neurons, ultimately leading to the death of affected motor neurons. Motor neurons are defined as nerve cells located in the central nervous system (CNS) whose axons project outside of the CNS to either directly, or indirectly control muscles. Motor neurons are efferent nerves, which carry signals to muscles from the spinal cord to produce a movement (i.e. contraction). Motor neurons can be categorized as either upper or lower. Upper motor neurons travel down the spinal cord from the CNS, where they synapse with lower motor neurons which travel from the spinal cord to specific motor units in muscle. The degeneration of motor neurons caused by ALS affects both the upper and lower motor neurons, causing the neurons to die or degenerate progressively until they are no longer capable of transmitting messages to the muscle to induce contraction. Atrophy of muscle, along with the development of fasciculations (fine twitches), in subjects with ALS, is attributed with the aforementioned inability to properly function. Subjects diagnosed with ALS are given a general life expectancy of roughly three to five years, after the onset of symptoms, due to the accelerated deterioration of the body; however, an estimated 10% of individuals with ALS survive for 10 or more y... ... middle of paper ... ... J., Koppers, M., Berg, L. H., & Pasterkamp, R. J. (2013). Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathologica,125(6), 777-794. [5] #Mackness, B., Tran, M., McClain, S., Matthews, R., & Zitzewitz, J. (2014). Folding of the RNA REcognition Motif (RRM) Domains of the Amyotrophic Lateral Sclerosis (ALS)-linked Protein TDP-43 Reveals an Intermediate State.The Journal Of Biological Chemistry,289(12), 8264-8276. [6] #Gerber, Y. N., Privat, A., & Perrin, F. E. (2013). Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis.Frontiers in cellular neuroscience, 7(280), N/A. [7] #Castillo, K., Nassif, M., Valenzuela, V., Rojas, F., Matus, S., Mercado, G., et al. (2013). Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.Autophagy, 9(9), 1308-1320.
Adler, D. (1997). Lou Gehrig: The luckiest man. Ill. Terry Widener Orlando, FL.: Harcourt Inc. 32 pg. ISBN: 0-15-202483-2. This is an emotionally driven illustrative true story about the life and tragic death of the baseball great Lou Gehrig. His teammates and fans due to his record 2,130 games as a New York Yankee affectionately knew Gehrig as the “Iron Horse”. Gehrig put up numerous other records in the early twentieth century, including three of the top six RBI seasons in baseball history and
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Amyotrophic Lateral Sclerosis is better known as ALS or Lou Gehrig’s disease. Amyotrophic Lateral Sclerosis was not brought to International or national attention until Famous New York Yankees baseball player, Lou Gehrig, was diagnosed with it in 1939. Jon Stone, the writer and creator of Sesame Street, was also diagnosed with Amyotrophic
Research Paper According to www.medterms.com , ALS is defined as “a classic motor neuron disease. Motor neuron diseases are progressive chronic diseases of the nerves that come from the spinal cord responsible for supplying electrical stimulation to the muscles. This stimulation is necessary for the movement of body parts.” “1 out of 10 cases are a genetic defect” (Amyotrophic lateral sclerosis- National Library of Medicine, 2012). The other nine times, the cause of cannot be determined. As stated
sentence. That is the sad fate for the people diagnosed with Amyotrophic lateral sclerosis (ALS). “Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder was first described by Ran in 1850. This description was then expanded in 1873 by Charcot, who emphasized the involvement of the corticospinal tracts. In the United States, ALS is often referred to as Lou Gehrig's disease, after the famous ball player who was stricken by the disease in the midst of his career. (Yale School of Medicine, 2014)”
Amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. Jean-Marie Charcot was the first to recognize ALS as a distinct neurological disease with its own unique pathology. In ALS, nerve cells degenerate and deteriorate, and are unable to transmit messages to muscles. In around 90% of the cases of ALS, the cause remains unknown. Studies have concentrated on the responsibility of glutamate
Lou Gehrig’s Disease or Amyotrophic Lateral Sclerosis (ALS) is a collection of rare neurological diseases that affect the motor neurons that control the voluntary muscle movements. ALS is a progressive neurodegenerative illness that affects the nerve cells in the brain and spinal cord. ALS is a disease that belongs to a wider group of disorders that are known as motor neuron diseases. This is caused by gradual deterioration and the death of motor neurons. ‘Amyotrophic’ comes from the Greek roots
with ALS Amyotrophic Lateral Sclerosis is a disease that everyone should fear. Once the disease is in your body, there is no found cure but riluzole therapy is something that may extend life expectancy. Odds are for every 100,000 years, 2 people acquire the disease, with the majority being of the male sex. “Most people who develop Amyotrophic Lateral Sclerosis are between the ages of 40 and 75, with the majority after age 60, although it can occur at a younger age.” Amyotrophic Lateral Sclerosis
Lou Gehrig Henry Louis Gehrig was born June 19, 1903 in New York. His parents, who were immigrants from Germany, often felt the struggles of providing for their only surviving son. Gehrig’s mother worked tirelessly to make sure her son had a better life in America. She encouraged him to attend college, and in 1921 Gehrig began his college career at Columbia where he received a football scholarship. Gehrig was spotted by the New York Giants baseball manager, John McGraw, the summer before he started
Lou Gehrig's disease is often referred to as Amyotrophic lateral sclerosis (ALS), this is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Motor neurons come from the brain to the spinal cord and from the spinal cord to the muscles throughout the entire body. The progressive degeneration of the motor neurons in ALS would eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is
characters Mitch and Morrie, in Tuesdays with Morrie. Amyotrophic lateral sclerosis (ALS) often referred to as Lou Gehrig’s disease is a form of motor neuron diseases. It is a rare disorder in which the nerves that control muscular activity degenerate within the brain and spinal cord. What results is weakness and wasting away of the muscles. The cause is unknown. About one to two cases of ALS are diagnosed annually per 100,000 people in the US. (Lou) Sufferers will notice weakness in the hands and arms
of these talents was Lou Gehrig, one of the greatest baseball players of all time. He started off small, but quickly rose to the top, known by almost everyone in the nation. But Gehrig suffered one of the rarest degenerative diseases, now known as Lou Gehrig’s disease. He was able to bond the nation over his determination and kindness. Gehrig brought much to the plate during his fourteen-year career, something not many other baseball players have been able to accomplish. Lou Gehrig was born on June
For this rhetorical analysis paper I chose one of my favorite, and most famous, sports speeches of all time, Lou Gehrig’s farewell to baseball address. Lou Gehrig was a famous baseball player in the 1920’s and 30’s. Lou didn’t really need to use a attention getting introduction, he was well known and loved by so many that people piled into Yankee Stadium to watch and listen to him give this speech. Although he didn’t need an attention getter, he began his speech with one of the greatest baseball
11727 Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis (ALS) is a disease that affects the nerve cells in the brain and spinal cord, specifically the motor neurons. Motor neurons carry signals from the brain and spinal cord to all of the muscles in your body. When a person has ALS, they are not able to generate enough motor neurons, and the brain cannot then initiate and control muscle movement. After some time, when the disease gets progressively worse, the patient has difficulty speaking
Amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig’s disease, is a neurological disorder that affects roughly one in 200,000 people (DiDonato et al., 2003). As such, ALS is among the most common neurological disorders found in humans. It typically occurs mid-life and kills motor neurons, which leads to paralysis and death. Most cases of ALS do not show a genetic linkage. However, five to ten percent of cases are, in fact, inherited in an autosomal recessive manner (DiDonato et al., 2003)
The Causes Of Developing ALS And CTE Athletes in various sports have been diagnosed with Amyotrophic Lateral Sclerosis, and Chronic Traumatic Encephalopathy. Both of these diseases are life threatening, and the chances of living are very slim. Athletes are choosing to play at their own risk, and because of this many of them have died, and are still currently living but have to suffer through the symptoms. Both of these diseases are fatal, and still to this day there is no possible cure that can