Essay on Amnesia Parallels

Essay on Amnesia Parallels

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I chose an article concerning an experiment regarding retrograde amnesia in mice and what affects it might have on the study of human retrograde amnesia. The article was composed by Larry R. Squire, Ph.D. and Curt W. Spanis, Ph.D. Doctor Squire is a Professor of Psychiatry, Neurosciences and Psychology at the Veterans Administration Hospital in San Diego, California. Doctor Spanis was a Professor at the Department of Biology at the University of San Diego.
The purpose of this study was to establish steadiness between the results of mice and humans with regards to retrograde amnesia (Squire, 1984, p.345). The article was about an experiment in which five hundred and sixty male albino mice. “These mice were trained in a one-trial, step-through passive avoidance task, a standardized and much used method for the study of memory in rodents” (Squire, p.346). The experiment implicated mice being trained to complete a particular assignment. There were to groups of participants, an experiment group and a control group. The mouse was placed in a compartment. Inside the compartment was a door to another compartment. After a predetermined amount of time the door would open and the mouse would enter the second compartment, as the mouse entered the second compartment, it received a footshock. A footshock is a mild electric shock through the floor into the mouse’s foot. The mouse was allowed to withdraw into the first compartment. A second trial with no footshock was conducted, in which the mouse was timed to record how long it waited to enter the second compartment. During the trials fifteen percent of the five hundred and sixty albino mice died. After this “training” the experimental group was given electroconvulsive shock administered at 1-...


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...rganization of mammalian memory at the level of neural systems and cognition.







Works Cited


Squire, L. R., & Spanis, C. W. (1984). Long gradient of retrograde amnesia in mice: Continuity with the findings in humans. Behavioral Neuroscience, 98(2), 345-348, Retrieved from http://0-ehis.ebscohost.com.library.ecok.edu/ehost/pdfviewer/pdfviewer?sid=b3cb3e90-5f9c-4bf5-874b-bbb482ee8ce3%40sessionmgr104&vid=6&hid=114 doi: 10.1037/0735-7044.98.2.345
Squire, L. R., & Spanis, C. W. (1984). Long gradient of retrograde amnesia in mice: Continuity with the findings in humans. Behavioral Neuroscience, 98(2), 345-348. doi:10.1037/0735-7044.98.2.345
Squire, L.R., Slater, P.C., & Chace, P.M. (1975). Retrograde amnesia: Temporal gradient in very long-term memory following electroconvulsive therapy. Science, 187, 77-79

http://psychiatry.ucsd.edu/faculty/lsquire.html

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