The gene that is usually responsible for Alzheimer ’s disease (AD) is the Apolipoprotein E (APOE gene) which gets its name from encoding for the protein Apolipoprotein. It is on chromosome 19 and has three main alleles on the gene that seem to be responsible for this disease. They are: ε2, containing cysteine at position 112 and arginine at position 158 of the gene, ε3 containing cysteine at both 112 and 158 positions, and ε4 containing arginine at both 112 and 158 positions of the gene. The APOE ε4 allele is the disease’s most prevalent allele. The APOE ε4 allele is the disease’s most prevalent allele. The function of this gene is to regulate cholesterol and triglyceride metabolisms. This shows it is not only coincidental that high cholesterol and diabetes lead to late-onset Alzheimer’s. The APOE ε4 allele was tested and discovered to be so dangerous in 1993. Since, many more studies have been completed on this allele and it has been known to be the main cause of Alzheimer’s disease.
Once all the human genotype was known after using the Human Genome Project, a microarray system used to study over 80 percent of the Caucasian genome for association signals called the 500K GeneChip from Affymetrix was created. This microarray kit was used to confirm that using high-density single nuc...
... middle of paper ...
...sion, the results point researchers in the right direction proving that late on-set Alzheimer’s is very closely related to this APOE locus, especially the ε4 allele. Further studies may also show that this allele will likely contribute to other diseases as well. With the use of ultra-high density genome, further associations will be made regarding the link between late on-set Alzheimer’s and the APOE locus.
Coon, Keith D. Ph.D.; Amanda J. Myers, Ph.D.; David W. Craig, Ph.D.; Jennifer A. Webster, B.A.; John V. Pearson, B.Sc.; Diane Hu Lince, Ph.D.; Victoria L. Zismann, M.S.; Thomas G. Beach, M.D.; Doris Leung, M.D. “A High-Density Whole-Genome Association Study Reveals That APOE Is the Major Susceptibility Gene for Sporadic Late-Onset Alzheimer’s Disease.” Physicians Post Graduate Press. J Clin Psychiatry 68:4, April 2007: 613-618. (Print)
Need Writing Help?
Get feedback on grammar, clarity, concision and logic instantly.Check your paper »
- Even in a world of modern medicine and major medical advancements like the world has never seen before, some diseases still continue to plague the human race and confuse even some of the brightest scientists today. Unfortunately, Alzheimer Disease (AD) is one of them and it affects between 2.4 and 4.5 million people in America. Alzheimer’s is usually diagnosed in people over the age of 65, but in rarer cases people as young as 16 have it. Since it is a degenerative disease, patients develop it with few symptoms at an earlier stage, but then it gradually becomes more predominant in how the patient lives his or her life, developing into dementia ⨥.... [tags: Alzheimer's Disease Essays]
508 words (1.5 pages)
- Alzheimer’s Disease is an irreversible, genetically linked illness. This disease was chosen for the topic of this essay under the consideration that in many families the illness can be incredibly tragic, passing down for generations without mercy. It is not rare to encounter families in which each member is afflicted with a form, mild or severe, of Alzheimer’s. The disease is a progressive brain disease which comes in two separate types: Early-Onset Alzheimer’s Disease and Late-Onset Alzheimer’s Disease.... [tags: Alzheimer's Disease Essays]
1242 words (3.5 pages)
- Alzheimer’s Disease Alzheimer’s disease is a progressive degenerative disease that attacks the brain and results in impaired memory, thinking and behavior. Alzheimer’s is the most common form of dementia. Dementia is the lost of thinking, remembering and reasoning so bad it screws up ability to do daily functions and eventually resolves in death. Dr. Alois Alzheimer’s first discovered the disease in 1906. Since then research has developed a deeper understanding of the changes in the brain.... [tags: Alzheimer's Disease Essays]
1070 words (3.1 pages)
- Alzheimer's Disease Dr. Alois Alzheimer in 1906 was the first to described Alzheimer's disease (AD). Millions of people have been diagnosed with the disease ever since. Alzheimer's disease (pronounced Alz'-hi-merz) is a progressive, degenerative disease that attacks the brain and results in impaired memory, thinking and behavior. Frequently Asked Questions Does Alzheimer's disease occur in younger adults. Yes, though less frequently. The disease can occur in people in their 30s, 40s and 50s, however, most people diagnosed with Alzheimer's are older than 65.... [tags: Alzheimer's Disease Essays]
662 words (1.9 pages)
- Alzheimer's Disease Alzheimer¡¦s disease is a slow, progressive, and degenerative disease of the brain. This disease is marked by a gradual loss of memory and other cognitive functions. "Alzheimer's Disease is also known as the most common cause of dementia--a general term referring to the loss of memory and the ability to think, reason, function, and behave properly" (Medina,1999). It primarily affects adults in their 60's or older and eventually destroys a person's ability to perform simple, routine tasks or even to care for themselves.... [tags: Alzheimer's Disease Essays]
1720 words (4.9 pages)
- Alzheimer's Disease Alzheimer’s disease is the disease of the century. This disease is affecting many lives, families, and caregivers. This research presented is to help educate on the topic of Alzheimer’s disease, which many people aren’t aware enough about. Statistics are given to show how extreme this disease is, and how many people it’s affecting in society. Also statistics are presented that give the amount of money being spent relating to Alzheimer’s disease. This research explains the symptoms, diagnosis, and treatment of the disease.... [tags: Alzheimer's Disease Essays]
2412 words (6.9 pages)
- What Is Alzheimer's Disease. Alzheimer's disease is a progressive, degenerative neurological disorder that leads to impairments in memory, thinking and reasoning. It is a late-life illness that causes a form of brain failure. It produces confused thinking, impairs judgment, changes personality, alters behavior. The illness is progressive and ultimately results in death. While it cannot be cured, it can be treated. During the earliest stages of Alzheimer's disease, many people are aware that their memory is failing.... [tags: Alzheimer's Disease Essays]
890 words (2.5 pages)
- Alzheimer's Disease A description of the symptoms and possible causes of Alzheimer's disease as an example of brain malfunction Alzheimer's disease is one of a number of forms of dementia. This type of illness affects the brain by gradually reducing the number of brain cells. This decline in brain tissue can occur in all parts of the brain. However, Alzheimer's deals mainly with the Cerebrum part of the brain. The Cerebrum controls intelligence, memory, language skills, emotions and personality.... [tags: Alzheimer's Disease Essays]
413 words (1.2 pages)
- Alzheimer’s Disease Alzheimer’s is a disease of the brain that causes a steady decline in memory. This results in dementia, which is loss of intellectual functions severe enough to interfere with everyday life. Alzheimer’s disease is the most common cause of dementia, affecting ten percent of people over 65 years old, and nearly 50 percent of those age 85 or older. My grandmother was diagnosed with “probable” Alzheimer’s disease over two years ago. After finding this out, I wanted to know more about this particular disease.... [tags: Alzheimer's Disease Essays]
715 words (2 pages)
- Alzheimer’s disease is described as a progressive brain disorder that gradually destroys a person’s memory and clarity to learn, reason, make judgments, communicate, and carry out daily life. (r.1) Alzheimer’s is a disturbing disease affecting millions of elderly people. A person’s risk for the disease is fifty-percent when they reach the age of eighty-five.(r.1) Scientists have been studying the disease for many years now in hope to find answers to a cure for this depressive disease. The disease is persistently being studied with the hope of cures, and a better understanding of how one person can conquer Alzheimer’s disease.... [tags: Alzheimer's Disease Essays]
1428 words (4.1 pages)