Question 1. a) Testosterone belongs to steroid family and it is a hydrophobic and insoluble molecule. In the body, over 95% of testosterone molecule are bound to proteins rather than staying in a free state. To fulfil its regulatory function, testosterone molecules need to be transported from the cytoplasm into the nucleus. However, this activity cannot be achieved themselves as they are prone to be repelled by hydrophilic head part of the nuclear membrane. Therefore, a carrier protein (androgen receptor) is needed for the cross-membrane transport and the delivery of testosterone. b) One hydrogen bond forms between carbonyl oxygen atom on testosterone and electronegative N atom on arginine side chain; hydrophobic interactions form between methyl group on two valine residues and testosterone central ring structure; phenyl group on phenylalanine forms a hydrophobic interaction with testosterone rings as well. Other hydrogen bindings and hydrophobic interactions also exist in the structure but they are not labelled, hence not discussed. c) To reduce the testosterone affinity, the first consideration should be put on the hydrogen bond between arginine and carbonyl oxygen as it is a relatively strong interaction. Arginine could be replaced by methionine or other amino acids whose sides chain is not electronegative …show more content…
This hydroxyl group has potential to form multiple hydrogen bonds with neighbouring amino acid residues, hence mutations should be made on these neighbouring amino acids so that stronger H-bond interactions could be formed between the receptor and testosterone. The Same principle also applies on amino acids that close to the carbonyl group. Serine or tyrosine may be used to replace neighbouring amino acids to create more H-bonds between receptor and testosterone. With these additional H-bonds, the affinity of the testosterone is supposed to increase
According to the text, “Lipid-soluble hormones are small in size, and has low solubility in aqueous fluid (Chapter 17, p. 573)”. Because of the property of this hormone, the probability of getting eliminated in the blood stream or the body is high. If this happens, these hormones can be eliminated through the kidneys. So in order for these hormones to not be eradicated in the system, it will need assistance from a binding protein.
Trenbolone is a steroid that mimics testosterone. Please select all of the possible effects of testosterone. More than one may
Today farmers use six anabolic steroids in various combinations. “Those anabolic steroids are osetradiol, progesterone, testosterone, zeranol, trenbolone, and melengestrol.” (Communication Foundation) There are three natural steroids that are used as well. The natural steroids are estradiol, testosterone, and progesterone. Also used are three synthetic hormones which include estrogen compound zeranol, andgrogen trenbolone acetate, and progestin melengestrol acetate. (Organic Consumer Association) However, when hormones are given to cattle some of the naturally occurring hormone levels could go up seven to twenty times the normal level. Scientists have growing concerns about the use of the hormones.
An analogy that fits very well with the study of the endocrine system is that of a message in a bottle. We can think of the body as a river, and a specific hormone may be a bottle containing a message. The organs or glands mentioned above would manufacture the “bottles'; (hormones) that would be released into the river (blood stream). If there were no receptor sites for the hormones in the body, then they would continue to flow along the river and probably not make their destination. However, there are systems of receptor sites that enable specific hormones to bind in specific places. Structure also plays a major role in determining which hormones are able to bind to which receptors.
Several effects of steroid use have been identified. These include an increase in low density lipoprotein (LDL) cholesterol and a decrease in high density lipoprotein (HDL) cholesterol. These lipid changes if allowed to continue over long periods of time could result in coronary heart disease (6). Some other side effects of steroids in men include shrinking of the testicles; reduced sperm count, infertility, baldness, development of breasts, and increased risk of pro...
The IR spectrum that was obtained of the white crystals showed several functional groups present in the molecule. The spectrum shows weak sharp peak at 2865 to 2964 cm-1, which is often associated with C-H, sp3 hybridised, stretching in the molecule, peaks in this region often represent a methyl group or CH2 groups. There are also peaks at 1369 cm-1, which is associated with CH3 stretching. There is also C=O stretching at 1767 cm-1, which is a strong peak due to the large dipole created via the large difference in electronegativity of the carbon and the oxygen atom. An anhydride C-O resonates between 1000 and 1300 cm-1 it is a at least two bands. The peak is present in the 13C NMR at 1269 and 1299 cm-1 it is of medium intensity.
The two basic forms steroids come in are water-based and oil-based. The water-based are pil...
Artificial testosterone was first synthesized in 1935 and was intended as a hormone replacement for patients who were not able to produce enough testosterone. The first documented incidence of steroid abuse in sports was at the 1954 World Weightlifting Championships. The Soviets easily dominated all of their weight classes, so Dr. John Ziegler of the US team questioned the Soviet doctor about steroids. The Soviet doctor was not afraid to admit that his athletes were injected with testosterone, and because there were no regulations in place to address the issue, they went unpenalized for their actions. Thus, Dr. Ziegler set out to create an oral testosterone derivative, superior to the Soviet injectable version, and his effort led to the creation of Dianabol in 1958, the most commonly abused anabolic of all time. (“Steroid Abuse in Sports”, “Steroid Timeline”).
Although steroids have many negative effects, they have many needed medical purposes. Androgens have many legitimate medical uses, such as the use for treatment of hypogonadal men to compensate for the lack of endogenous production. Anabolic steroids are also helpful for the treatment of certain adolescent diseases, some types of anemias, and for a relatively rare form of edema. Other clinical uses focus on the tissue building and anti-catabolic effects, such as in the treatment of burn victims, AIDS, or HIV positive patients, or patients malnourished from disease or old age (Bellino 1).
A man has been married to his wife for seven years. The couple has two beautiful children, a fabulous home, and appear to have the perfect marriage. After the husband leaves work one afternoon, he decides to stop in at the local bar. The man sits at a table in the corner of the room. Not long after his arrival, a woman approaches him. She asks the man if she can join him at his table. The two seem to have quite a bit in common and enjoy each other’s company. The woman asks if he would like to go back to her apartment. He has not had a fight with his wife today. In fact, she surprised him with a love note in his briefcase. Their sex life is enjoyable, frequent, and without complaint. The couple is not currently having financial problems. Despite this, why did the man decide to leave with a stranger and cheat on his wife? A great deal of research has been carried out on the topic of infidelity. Marital therapists have reported that more than half of the couples they counsel are in therapy as a result of infidelity (Atkins, Jacobson citation). Therapists also consider an extramarital affair as, “one of the most damaging relationship events and one of the most difficult problems to treat in couples therapy” (whisman predicting sexual infidelity…). Some therapists estimate that 50% to 65% of couples seek help after an incident of infidelity in their relationship (Atkins, Jacobson & Baucom). Identifying the reasons for this problem are essential to the success of its reduction. Infidelity is not a new phenomenon. However, there was little research on the topic until the late 1970’s (Drigotas & Barta, 2001). Numerous factors have been examined while trying to determine the root cause for extramarital relationships a...
“Steroids are any type of a large group of fat-soluble organic compounds, as the sterols, bile acids, and sex hormones most of which have specific physiological action” (Dictionary.com). When our bodies are still developing, the effects of steroids can be dangerous and can also be permanent (“Above”). Steroids are made out of substances such as nandrolone, stanozolol, testosterone, fluoxymestrone, and oxandrolone. Sometimes people say when you can’t pronounce something, you probably shouldn’t use it. In the 1940’s testosterone began to be widely used in competitive sports, but the dangers of loading up on testosterone were not yet clear (“History”). Instead of using steroids for a bad reason, there is a medicinal purpose. Cortisteroids can treat arthritis, asthma, lupus and multiple sclerosis, eczema and rashes, and some types of cancer (“Steroids: Medline”). Also, steroids can be used to treat anemia, to improve weight loss due to severe illness, and to treat osteoporosis. Steroids can only be sold to you by a pharmacist f...
Proteins are considered to be the most versatile macromolecules in a living system. This is because they serve crucial functions in all biological processes. Proteins are linear polymers, and they are made up of monomer units that are called amino acids. The sequence of the amino acids linked together is referred to as the primary structure. A protein will spontaneously fold up into a 3D shape caused by the hydrogen bonding of amino acids near each other. This 3D structure is determined by the sequence of the amino acids. The 3D structure is referred to as the secondary structure. There is also a tertiary structure, which is formed by the long-range interactions of the amino acids. Protein function is directly dependent on this 3D structure.
Steidle, C. "AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function." Review. n.d.: n. pag.The Journal of Clinical Endocrinology & Metabolism. June 2003. Web. 20 Nov. 2013. .
The male reproductive system is a set of organs that works together to produce sperm which will later in life fertilize females eggs. The testes are the most important part of the system because it produces sperm cells. It is similar and looks similar to ovaries of a female’s reproductive system because it also holds what they need to reproduce. Its job is to produce the sperm cells needed to reproduce. Due to hormonal imbalances the production of sperm cells may not even be possible in some males. Testosterone is the male the hormone that gives men there manly characteristics. It is made up of hydrogen, carbon, and oxygen with a white color. In the male body it helps develop sex organs, a deeper voice, and facial hair (Khalid, 2013). Cancer or a genetic disorder in males is the most common thing that cause the reductions of testosterone production in the body. Behind the testes is the epididymis which lets sperm go through the vas deferens from the testes (Dictionary, 2014). It looks like leach the way it is position right on the testes but it is thinner. When sperm is produces the ...
Molecular pharmacology deals with the biochemical and biophysical characteristics of interactions between molecules of different substances and those of the cell. In other words, it is molecular biology applied to pharmacologic and toxicologic questions. The methods of molecular pharmacology include precise mathematical, physical, chemical and molecular biological techniques to understand how cells respond to hormones or pharmacologic agents, and how chemical structure correlates with biological activity of various