I. Name of Disorder:
The official name of the disorder is Diabetes Mellitus. Most people just know it as diabetes. There are two major classifications of diabetes mellitus; insulin-dependent (IDDM) and noninsulin-dependent (NIDDM). IDDM is more commonly known as Type 1 Diabetes, and NIDDM is known as Type 2 Diabetes (Ekoé, 2008). Type 1 diabetes is the juvenile-onset diabetes that deals with the complete destruction of β-cells of the pancreas whereas type 2 diabetes is an adult-onset disorder in which individuals suffer from an insulin deficiency (Ekoé, 2008).
II. Chromosomal location:
The main location of diabetes type 1 or IDDM is on the short arm of chromosome 6 at the band 21.3. IDDM is mostly influenced by the HLA class II region (Ekoé, 2008). Diabetes type 2 or NIDDM is located on several different chromosomes, and even different arms. The chromosomes that contain NIDDM are chromosomes 2-8, 10-13, 15, 17, 19, and 20.
III. Type of Inheritance:
Diabetes Mellitus is a multifactorial disorder; it is effects by both genes and the outside environment. Type 1 diabetes is shown to have a similarity throughout families, but there is no distinct pattern of inheritance (Savage & Bain, 2013). Geneticists are in a total controversy over the actual mode of inheritance of IDDM. There are hypotheses that it is autosomal recessive, autosomal dominant, some autosomal dominant and some autosomal recessive, intermediate gene dosage model, a heterogeneity theory, and a two-locus disorder (Rotter, 1981). The mode of inheritance that is most supported and accepted would be the heterogeneity because a single genetic disorder (IDDM) is caused by multiple alleles (Rotter, 1981). Type 1 diabetes also falls under heterogeneity because of the conc...
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Diabetes mellitus, habitually referred to as diabetes is caused by a decline in insulin secretion by the cells of the pancreatic islet resulting into a surge in blood glucose concentration, a condition known as hyperglycemia. Diabetes insipidus is a disorder defined by the secretion of huge quantities of highly diluted urine, this is regardless if a reduction in fluid intake. This is as a result of a deficit of anti-diuretic hormone (ADH) also known as vasopressin produced by the posterior pituitary gland. The disorder diabetes mellitus is associated by extreme reduction in weight, a higher urge for urination, also known as polyuria, higher levels of thirst (polydipsia) and an extreme craving to eat known as polyphagia. This disorder has been categorized as Type 1 or insulin dependent diabetes and Type 2 or non-insulin dependent diabetes another type is the Gestational diabetes. The Type 1 diabetes mellitus is portrayed by a deficiency of the insulin-secreting beta cells of the islets of Langerhans found in the pancreas, this leads to a shortage of insulin. The principal cause for this deficiency of beta cells is a T-cell mediated autoimmune onslaught. In children, Type1 diabetes is known as juvenile diabetes. The Type 2 diabetes mellitus is as a result of insulin resistance or diminished insulin sensitivity coupled to a reduction in insulin production.
Diabetes Mellitus is a disease of the endocrine system primarily differentiated between type 1 and type 2. Type 1 diabetes occurs when the pancreas is unable to produce insulin and was previously seen in the younger generation which is no longer the case.1 Type 2 diabetes is the more prevalent of the two types and involves elevated blood sugar levels due to the insufficient production of insulin. Risk factors that make an individual higher risk for type 2 diabetes include increasing age, obesity, family history, a sedentary lifestyle.1,2 Innovative drug therapies for type 2 diabetes remain important for the treatment and reduction of the disease.
Diabetes Mellitus can be classified into three main types: Type 1 - Insulin-dependent diabetes, Type 2 - Noninsulin-dependent diabetes, and Gestational diabetes mellitus.
Diabetes is a disease that affects the body’s ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy. Diabetes falls into two main categories: type 1, or juvenile diabetes, which usually occurs during childhood or adolescence, and type 2, or adult-onset diabetes, the most common form of the disease, usually occurring after age 40. Type 1 results from the body’s immune system attacking the insulin-producing cells in the pancreas. The onset of juvenile diabetes is much higher in the winter than in the summer. This association has been repeatedly confirmed in diabetes research. Type 2 is characterized by “insulin resistance,” or an inability of the cells to use insulin, sometimes accompanied by a deficiency in insulin production. There is also sometimes a third type of diabetes considered. It is gestational diabetes, which occurs when the body is not able to properly use insulin during pregnancy. Type 2 diabetes encompasses nine out of 10 diabetic cases. Diabetes is the fifth-deadliest disease in the United States, and it has no cure. The total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. Diabetes risk factors can fall into three major categories: family history, obesity, and impaired glucose tolerance. Minority groups and elderly are at the greatest risk of developing diabetes.
Current theories link the cause of diabetes, singly or in combination, to genetic, autoimmune, viral, and environmental factors (obesity, stress). Regardless of its cause, diabetes is primarily a disorder of glucose metabolism related to absent or insufficient insulin supplies and/or poor utilization of the insulin that is available. The two most common types of diabetes are classified as type I or type II diabetes mellitus. Gestational diabetes and secondary diabetes are other classifications of diabetes commonly seen in clinical practice
First of all, diabetes also known as diabetes mellitus is a metabolic disease that a person gets from high blood glucose or when your bodies cells do not respond to insulin and in some cases both (Medical News Today). There are three types of diabetes type 1, type 2, and gestational. All cases of diabetes do not affect you the same and all have different syndromes that will affect your body differently. While men can get two of these cases of diabetes, women can get all three.
As of the year 2011, 28.8 million people living in the United States were suffering from diabetes. This accounts for 8.3% of the US population (CDC, 2011). While this number may seem small, diabetes is a rapidly growing disease that needs a solution given that it is the seventh leading cause of death. According to the American Diabetes Association, (A.D.A.), diabetes is a condition in which the pancreas is unable to produce the amount of insulin needed to convert food, sugars, and starches to energy for the body. Therefore, the blood sugar levels rise, also known as hyperglycemia. There are two types of diabetes: Type 1 and Type 2. Type 1 diabetes is commonly found in children or young adults and only makes up 5% of diabetes cases. A person with Type 1 diabetes does not produce insulin at all. Type 2 diabetes is the more common form of the disease. People who struggle...
Diabetes mellitus is a group of metabolic disorders characterized by inadequate insulin secretion by the pancreas or cellular destruction leading to an insulin deficiency. Depending on the cause of the insulin shortage, diabetes can be subcategorized into type I and type II. Type I diabetes (T1DM) is usually mediated by the destruction of b-cells in the pancreas resulting in decreased insulin production and secretion. Type II diabetes (T2DM) is the failure of these b-cells to secrete adequate amounts of insulin to compensate for insulin resistance and increased gluconeogenesis combined with an overall resistance to the insulin action (8., 1997). T2DM accounts for 90 to 95 percent of all diabetes cases.
Thesis: Diabetes type 1 is different from type 2 and if given the wrong treatment it could lead to devastating consequences.
There are two main types of diabetes. The firsts is insulin-dependent diabetes mellitus (IDDM). In IDDM the body either doesn’t produce diabetes or produces very small amounts. The symptoms usually occur in teenagers under 20, usually around puberty. Untreated IDDM affects the metabolism of fat. Since the body can’t convert glucose into energy, it is broken down into fat and stored for energy. This also increases the amounts of ketone bodies in the blood, which interfere with respiration. The second type is called is non-insulin-dependent diabetes mellitus (NIDDM). This is when the body doesn’t make enough insulin or is unable to use it. NIDDM is the most common of all diabetes; it makes up 90 to 95 percent of all cases. Scientists believe that in some people weight gain or obesity is what triggers their diabetes because 80 percent of people with diabetes are over weight.
Type 2 DM is considered non-insulin-dependent and contains the vast majority of all diabetics, approximately 90 – 95%, wit...
Diabetes mellitus type 1 (also known as type 1 diabetes, or T1D; formerly insulin-dependent diabetes or juvenile diabetes) is a form of diabetes mellitus that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas.
Diabetes Mellitus is a disease in which the pancreas produces little or no insulin. Insulin is a hormone that helps the body’s tissues absorb glucose which is sugar, so it can be used as a source of energy. Glucose levels build up in the blood and urine which causes excessive urination, thirst, hunger, and problems with fat and protein metabolism in a diabetic person. Diabetes is very common in the United States; it is the seventh leading cause of all deaths. Women have been diagnosed with diabetes more than men. There are two forms of diabetes, Type one and Type two diabetes. Type one diabetes is when the body does not produce insulin or produces it in very small quantities. This usually occurs in younger people under twenty years of age, mostly around puberty. Type two diabetes is when the body’s balance between insulin production and the ability of cells to use insulin doesn’t work properly. This is more common than type one; about 90-95% people in the United States have it. There are no cures for diabetes now but there are many researchers investigating factors through new technologies to cure them. Meanwhile, technological advancements are being made to keep glucose at a good level for diabetes.
Diabetes mellitus is a group of metabolic disorders which is characterized by hyperglycemia due to insulin deficiency or resistance or both reasons. (1) According to that diabetes mellitus can be divided as type I and type II. This is common and its incidence is rising, 171 million people had diabetes in 2000 it is expected this condition to be doubled in 2030. It is spread in all the countries and therefore has become a major burden upon healthcare facilities. (2)
There are two types of diabetes. One is a type 1 diabetes and the other one is a type 2 diabetes.