Essay on A Short Note On Asthma And Its Effects On Asthma

Essay on A Short Note On Asthma And Its Effects On Asthma

Length: 1048 words (3 double-spaced pages)

Rating: Strong Essays

Open Document

Essay Preview

Asthma is a common chronic inflammatory of the airway [1]. The most common symptoms of asthma include wheezing, coughing, chest tightness and shortness of breath [2]. Asthma exacerbations, well known as asthma attack, occupy the main social and economic investment and cause higher mortality of asthma [3]. In sever conditions, asthma exacerbation could even lead to death by suffocation.
Recent studies suggest that the airway microbiome may play a significant role in pathophysiological processes associate with asthma [4].However, the role of microbiome in the pathogenesis of asthma has not yet been clarified. To further understand the mechanism of asthma exacerbation triggered by the changes in airway microbiome, a mathematic model of airway mechanics should be developed to reveal the complex interactions which could not reveal by the experimental analysis.
The aim of the project is to identify the role of microbiome in asthma exacerbation using system biology approach. The study will comprise of experimental data, mathematical modelling and in silico stimulation experiment to predict the mechanism of asthma triggered by the dysbiosis of the airway microbiome. Recent studies suggest that individuals with asthma have damaged bronchial epithelial barrier and mucus dysfunction [5][6]. Therefore, it is necessary to identify the behaviours of epithelial barrier function and mucus layer in asthmatic individuals.
An increasing evidence suggests that the composition of the microbiome of the airway may be essential to determine the risk of asthma development and contribute to chronic stable asthma [7]. ‘Hygiene hypothesis’ suggests that exposure to bacteria in early childhood will decrease the risk of asthma but expo...

... middle of paper ...

...a. The mathematical models based on different scales have mainly concentrated on the mechanism of bronchoconstriction. For example, the model developed by Lauzon focused on the study of bronchial hyperresponsiveness via the behaviours of airway smooth muscle at different levels to predict the mechanisms of bronchoconstriction [18].

However, no mathematical model has been developed to determine the role of the airway microbiome and particularly the function of airway epithelial barrier and the function of mucus layer in the mechanism of asthma exacerbations. In addition, the complex interactions between the immune cells, the epithelial barrier, the airway microbiome and the mucus layer need to be clarified. It is significant to understand these essential elements of asthma exacerbations which might lead to more effective strategies in asthma prevention and treatment.

Need Writing Help?

Get feedback on grammar, clarity, concision and logic instantly.

Check your paper »

A Short Note On Asthma And Its Effects On Health Care Costs Essay

- INTRODUCTION Asthma is a common chronic disease worldwide and affects approximately 24 million persons in the United States (Morris, 2015). It is the most common chronic disease in childhood, affecting an estimated 7 million children. It is one of the most common reasons for visits in ambulatory settings and accounts for 16.5 million office visits each year (Buttaro, Trybulski, Bailey, & Sandberg-Cook, 2013, p. 408). Improperly managed and poor asthma control can lead to frequent emergency visits, hospital admissions, missed school days, absenteeism from work, and in worst cases, even death....   [tags: Asthma, Immune system, Inflammation, Allergy]

Strong Essays
1378 words (3.9 pages)

Short Note On The 's Disease Essay

- Ray is a 67 year old retired train engineer. He recently began having difficulty walking, maintaining his balance, and having constant fine shaking of his hands while at rest. As time passes his difficulties worsen. He moves slowly and his posture becomes stooped. He leans forward while walking and is prone to falling. He also complains of stiffness. Ray’s physician will immediately suspect Parkinson’s disease (PD). Ray’s age (being over 50) puts him at higher likelihood for PD. Ray’s signs that would lead his doctor to suspect PD are his involuntary resting tremors, bradykinesia, posture, and falling....   [tags: Parkinson's disease, Dopamine, Substantia nigra]

Strong Essays
853 words (2.4 pages)

A Brief Note On R.a ) ( Bogota ) Essay

- Patient, R.A was born in Colombia, (Bogota) on March 30, 1964 she came to Miami, FL 20 year ago, and she lives with her two sons. She was a professional salsa dancer always happy and healthy person traveling around the world, even though in her family history mother and father were Dx with a heart disease many years ago, she has never had any medical problems with her heart. On June 5 ,2005 Pt. R.A was having a dry cough chest pain her sons were worried about it because she had been feeling bad since 3 days ago ,and they wanted to take her to the hospital, but she always replied to them “ as an older person I have more experience about how to cure my flu than you, and I am going to p...   [tags: Asthma, Gastroesophageal reflux disease]

Strong Essays
1286 words (3.7 pages)

Causes And Effects Of Asthma Essay

- Causes and Effects of Asthma in Children Asthma is a chronic pulmonary condition effecting the airways and lungs of millions of Americans each year. In individuals with Asthma their airways become swollen, restricted and produce extra secretions ("Asthma," Mayo Clinic). Asthma has causes that range from cold air reaction, pollution within the air, viruses and allergies. The effects of asthma can be particularly hard on children because of underdeveloped lungs. Effects of asthma include restricted breathing, increased chances of viruses, and effects of medications additionally higher chance of hospitalization in children....   [tags: Asthma, Immune system, Allergy, Food allergy]

Strong Essays
1372 words (3.9 pages)

Essay on Environmental Pollution And Its Effects On The Natural World

- One of the greatest problems that the world is facing today is that of environmental pollution, increasing with every passing year and causing grave and irreparable damage to the earth. There are several types of pollution, and while they may come from different sources and have different consequences, understanding the basics about pollution can help environmentally conscious individuals minimize their contribution to these dangers. In total, there are seven recognized sources of pollution in the modern world....   [tags: Pollution, Soil contamination, Environmentalism]

Strong Essays
1146 words (3.3 pages)

Essay on End Stage Copd : Asthma As A Child

- End-stage COPD - FEV1 0.71L 2014 ex-smoker - quit 2014 Asthma as a child Dyslipidaemia Thank you very much for referring Richard along for further investigation and management of his three-four month history or worsening shortness of breath on exertion. As you are aware, he was diagnosed with severe COPD, with an FEV1 or 25% of predicted and at that stage, gave up smoking. Despite the very limited lung function, since that time he has coped very well. He continues to work in a clerical role with a very supportive company and lives with two housemates....   [tags: Asthma, Pulmonology]

Strong Essays
912 words (2.6 pages)

Clinical Hypnotherapy For Asthma? Essay

- Clinical Hypnotherapy For Asthma - When to Seek Asthma Treatment What is asthma. The NIH describes as a chronic disease of the lungs where the airwaves are extremely agitated and Wayne. This typically happens during the early morning or late in the evening where person expelling shortness of breath, chest tightening and coughing. While there are many possible solutions that exist on the market, asthma sufferers are increasingly open to alternative therapies like hypnotherapy and can be sintered when evaluating psychological triggers associated with asthma attacks....   [tags: Asthma, Immune system, Salbutamol, Anxiety]

Strong Essays
1383 words (4 pages)

Essay on Preschool Asthma

- Hearing the word, asthma stops a mom in her tracks, sends her heart into palpations and sends her mind into a whirlwind. Asthma means a child cannot breathe and if the child cannot breathe, surely, the child will die. To the untrained parent, that is the take home message from the child’s pediatrician visit. However, in the vast majority of the cases, dying from asthma is simply not the case. Asthma is a chronic lung disorder that does not have to define the child but rather be part of the many identities that make up a child much like blue eyes....   [tags: Asthma Essays]

Strong Essays
917 words (2.6 pages)

Essay on Exercise-induced Asthma

- Exercise-induced asthma is an acute transient airway narrowing that occurs during and most often after exercise. It is objectively defined as a 10% fall in forced expiratory volume in the first second from baseline that may be measured up to thirty minutes following exercise (M&M). Exercise-induced asthma occurs not only in elite athletes and asthmatics, but it can also be found in non-asthmatics. The stimulation of exercise-induced asthma can range anywhere from inhaling allergens to hyperventilation or intense exercise....   [tags: Exercise-induced Asthma]

Strong Essays
1782 words (5.1 pages)

Asthma Essay

- Asthma Breathing is a vital process for every human. Normal breathing is practically effortless for most people, but those with asthma face a great challenge. During an asthma attack, breathing is hampered, making it difficult or even impossible for air to flow through the lungs. Asthma is an increasingly common problem, and has become the most common chronic childhood disease. At least 17 million Americans suffer from it(1), and although it can be fatal, it is usually not that severe(4)....   [tags: Science Scientific Research Essays]

Strong Essays
1649 words (4.7 pages)