According to Nauck. (2014) there has been a greater understanding in the role that the kidneys play in glucose homeostasis, therefore more pharmaceuticals companies are developing an anti-diabetes medications that targets the kidneys. Sodium glucose co-transporter type 2 (SGLT2) inhibitors lowers renal reabsorption of glucose which enhances urinary glucose elimination resulting in a reduction of plasma glucose and glycosylated hemoglobin concentrations.
In search for an answer for this week’s discussion I researched many articles, I came across an article by Whalen, et al. (2015) which discussed the SGLT2 inhibitors use in the treatment of type 2 diabetes. This article reviewed the action and safety of SGLT2 inhibitors in the treatment of diabetes. In my current place of employment oral hypoglycemic are ordered frequently, but as a soon to be Practitioner I wanted to research on what is the latest approach to treating diabetes.
According to the Federal Drug Administration (2015) “SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes”. This class of medications acts on the kidneys by removing the sugar through urine. SGLT2 is a protein which helps glucose to be reabsorbed in the kidneys, SGLT2 inhibitors prevent the reabsorption of g...
... middle of paper ...
...the use of SGLT2 inhibitors.
This research was quiet informative , it will be helpful to know that there are other classes of medications that can help in the battle against type 2 diabetes. To study the use of how SGLT2 inhibitors works was an eye opener and the fact that it has been found to be safe and tolerated well makes it an option for the treatment of type two diabetes. However, on May 15, 2015 the FDA warned against its use because it may lead to ketoacidosis, which is a condition of great severity where the body produces high levels of ketones. The FDA recommended that it should be used as a second or third line of therapy rather than the reported monotherapy use. As the FDA further researches this class of medications, a clearer perspective will be given to future practitioners on whether the use of SGLT2 inhibitors is recommended for monotherapy use.
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