Appreciating Alzheimer’s disease The Alzheimer’s disease was discovered and named after Dr. Alois Alzheimer. The cause of Alzheimer’s disease is unknown but certain features have been identified. This disease has different stages mild, moderate and advanced. As it relates to people with early-onset Alzheimer’s, a genetic mutation is usually the mainspring. People who have the Late-onset Alzheimer’s originates from a complicated series of brain changes that occur over a long period of time. Current drug treatments are given to slow down the cognitive damage temporally. Scientist are currently researching that the disease may be triggered by different factors however age is the most known factor . This nerve racking disease called Alzheimer’s also known as AD was discovered in 1906 by Dr Alois Alzheimer a German physician, this was not considered a critical Disease until the 1970s.It all began with a documented case of a woman by the name Of Auguste D in her in fifties who showed signs of a cognitive disorder as it relates to her memory and socializing with her family. She later died and this great physician decided to do an autopsy on her brain, he then noticed a shrinkage in and around the nerve cells of her brain which led significantly to the discovery of this disease. There were many persons who contributed significantly to making this disease known like Emil kraepelin who worked along with Dr Alois but the great Robert katzman a New York pathologist who in the 1970’s made it recognizable where it became a major public health issue in the aging population. The Alzheimer’s disease affects ones memory, behavior and the way they think (1). The symptoms of this disease slowly worsen overtime where it affec... ... middle of paper ... ... how it progresses. These findings definitely sheds light for people who would like to know how amyloid plaques and tau build up in the brain. References 1. Knopman DS (2009). Alzheimer disease and other dementing illnesses. In EG Nabel, ed., ACP Medicine, section 11, chap. 11. Hamilton, ON: BC Decker. 2. Wilcock GK, Esiri MM (1982) Plaques, tangles and dementia . A quantitative study. J Neurol Sci 57: 407 – 417 3. ACT on Alzheimer’s. (2014) Alzheimer’s disease Curriculum, Module III: Societal Impact. What roles does tau play in the biological makeup of Alzheimer’s? 4. McKee AC, Kosik KS, Kowall NW (1991) Neuritic pathology and dementia in Alzheimer’s disease. Ann Neurol 30: 156 – 165 5. Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berlin) 82: 239 – 259»6. 6. Judith London PhD (2009) connecting the dots
While the average life expectancy of the world’s population has increased, the number of detected dementia cases has commensurately risen to astonishing levels. Along with improved discovery of this disorder, new causes and treatments have been found, from which many innovative techniques have been developed towards the prevention of future incidences and reduction of the effects of this condition; however, the quest for these solutions have raised more questions than it has answered. Why do some develop this disorder, while others do not? Can early detection be achieved to reverse the processes or limit its effects? Further specifics on these topics have been categorized into three main sections, which include:
Memory plays a significant role in the everyday lives of people of all ages. It allows them to recall information and remember skills that were learned in the past. Memory also organizes past information to help people make current and future decisions. However, imagine forgetting the names of close family members or not having the ability to find your keys every time you want to leave the house. These are some of the struggles that people with Alzheimer’s disease face daily. Alzheimer’s disease was first identified by German neurologist Alois Alzheimer in 1906, and was discovered to have an overpowering effect on explicit memory loss (Gruetzner, 1988). There are two types of Alzheimer’s disease – early onset and late onset. Early onset occurs in patients who are diagnosed before the age of 65 whereas late onset occurs in patients who are diagnosed after the age of 65. In the early stages of Alzheimer’s disease, short-term memory is often lost. As Alzheimer’s disease progresses, problems with long-term memory begin to develop, in addition to short-term memory impairments. Although a lot is known about the symptoms of Alzheimer’s disease, the cause has not been conclusively identified. However, as research continues, new theories about the cause of Alzheimer’s disease are being proposed. This has led to a controversy over whether Alzheimer’s disease is caused by genetics or environmental influences (Gruetzner, 1988).
Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.
The first case of dementia was discovered in 1906 by a German physiatrist Alois Alzheimer. It was first observed in a female patient and she was forty-one years old her name was Auguste D. Dr. Alzheimer observed a decline in the patient’s cognitive abilities. She lost her memory, she exhibited behavioral issues, and she suffered from hallucinations, lost the ability to comprehend language, disorientation and lost her speech. After Augusta’s passing Dr. Alzheimer preformed an autopsy that showed the classic triangles and knots we associate today with Alzheimer. Those triangles and knots are a proteins and plaque. The brain is self looked smaller and had distinct characteristics. Still with modern medicine the only way to diagnose a person with Alzheimer is after their death with an autopsy. (THE ALZHEIMER'S PROJECT, 2014).
In the 17th and the 19th century dementia was synonymous with insanity. Still many knew that people with this disease suffered from permanent damage that was irreversible unlike mental disorders where the brain remains intact (2006). Dementia was often known as senile which is common with old age. Studies through the years have shown that it is much more serious and causes damage to areas of the brain. Alois Alzheimer in 1910 noticed tangles, plaques, and arterio...
Alzheimer’s disease got its name from the German doctor, Dr. Alois Alzheimer. In 1906, he noticed that there were abnormal clumps and bundles of fibers i...
Alzheimer's Disease Introduction to Alzheimer's Alzheimer's disease is a progressive, degenerative disease of the brain. It was first described by the German neuropathologist Alois Alzheimer (1864-1915). in 1905. This disease worsens with advancing age, although there is no evidence. that it is caused by the aging process.
There are three stages towards Alzheimer’s and one should be aware of the important signs and symptoms. For instance, one should be aware of co...
Alzheimer’s disease is a neurodegenerative disease that attacks and destroys brain nerve cells or neurons eventually killing the cells. It is the most common form of dementia (around 50-60% of all cases of dementia). it affects 1 in 20 people over the age of 65 and 1 in 1000 people under the age of 65. Although it affects more people over the age of 65 it doesn’t mean that age is the cause of the disease. Patients suffering from Alzheimer’s disease suffer from memory loss, thinking difficulty, loss of language skills and changes in behaviour. No one is immune to this disease. Alzheimer’s disease is named after Dr Alois Alzheimer’s. In 1906 he noticed changes in the brain tissue of a woman who died from an unusual mental illness. Her symptoms included loss of memory, language problems and unpredictable behaviour. After her death he examined her brain and found abnormal protein fragments called plagues and tangles. These protein fragments are the two major features of Alzheimer’s disease. The third is the loss of connection between nerve cells and the brain.
In 1906, a German physician named Dr. Alois Alzheimer dealt with a patient that had been battling severe memory and confusion problems and had tremendous difficulty understanding questions and basic functions. Alzheimer suspected that the ailment had more to it than inherent memory loss. During an autopsy of the brain, he discovered that there were deposits of neuritic plaques surrounding the nerve cells and twisted fibers, known as neurofibrillary tangles, inside of the nerve cells. These observations became the definitive diagnosis of Alzheimer’s disease. The plaques and tangles that develop are a natural part of aging; however, they develop far more aggressively in Alzheimer’s victims. The plaques and tangles then block communication among nerve cells and disrupt the cells processes, eventually killing them. This destruction causes memory failure, personality changes, and problems carrying out everyday functions. Alzheimer’s especially attacks the memory. A victim in the later stage of the disease can...
There is no quick and easy way to diagnose Alzheimer’s disease. In fact a diagnosis can only be conclusively arrived at following autopsy of the ...
Alzheimer’s disease or AD is an incurable disorder of the brain that results in loss of normal brain structure and function. In an AD brain, normal brain tissue is slowly replaced by structures called plaques and neurofibrillary tangles. The plaques represent a naturally occurring sticky protein called beta amyloid and in an Alzheimer’s brain, sufferer’s tend to accumulate too much of this protein. Neurofibrillary tangles represent collapsed tau proteins which, in a normal brain along with microtubules, form a skeleton that maintains the shape of the nerve cells. In Alzheimer’s disease, the tau proteins break loose from their normal location and form tangles. Without the support of these molecules, nerve cells collapse and die. As normal brain structure is lost with progression of the disease, brain function also degenerates. Patients afflicted with Alzheimer’s disease display a gradual mental decline. Initially, and most apparently, there is a loss of short-term memory. Eventually, as a patient progresses to later stages of the disease, the brain becomes so damaged that patients can no longer communicate or recognize immediate family or even themselves. They have difficulty walking and standing and frequently fall. In the final stages, they lose bladder and bowel control and have difficulty with swallowing, frequently leaving them malnourished and dehydrated. Eventually, they are forced to remain bedridden and, without the help of life-prolonging measures provided in a hospital, die. However, this level of deterioration is severe and may take as long as twenty years. Because of the disease’s slow progress and its usual later start in a person’s life, a victim of AD will usually die first of natural causes. Under the objectives ...
Scientists still have not idea how Alzheimer’s disease process begins. Nevertheless, it seems likely that damage to the brain starts a decade or more before problems...
Dementia is an organic brain syndrome which results in global cognitive impairments. Dementia can occur as a result of a variety of neurological diseases. Some of the more well known dementing diseases include Alzheimer's disease (AD), multi-infarct dementia (MID), and Huntington's disease (HD). Throughout this essay the emphasis will be placed on AD (also known as dementia of the Alzheimer's type, and primary degenerative dementia), because statistically it is the most significant dementing disease occurring in over 50% of demented patients (see epidemiology).
There are four main types of dementia with AD being the most widespread form. It ac...