Wolbachia Symbiont Confers RNA Viral Protection in Drosophila

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Wolbachia is a common microbial symbiont that infects insects, including certain species of Drosophila. Bacteria within this genus are capable of propagating their transmission through Drosophila populations by manipulating an infected host’s ability to reproduce (Hamilton & Perlman, 2013). Wolbachia are able to create a selective pressure favoring their transmission by preventing infected fruit flies from having offspring with uninfected flies. Although these microorganisms disrupt host reproduction capabilities, they also confer fitness benefits. These bacteria provide Drosophila with increased resistance against multiple RNA-viral infections. The specific mechanisms of how they provide defense are currently speculative. This discovery has sparked questions regarding whether previously assumed parasites may in fact be mutualistic organisms (Hamilton & Perlman, 2013). One of the main problems with studying this symbiotic relationship in the lab is that Wolbachia cannot be cultured (Teixeira et al., 2008). Therefore, it is possible that ability to confer viral protection may be associated with other intracellular bacteria. However, studies have been able to conclude that the presence of Wolbachia in infected flies is almost exclusively associated with viral resistance (Teixeira et al., 2008). Future research groups hope to study into this symbiotic relationship in an attempt to pursue new methods of control over vector-borne diseases (Chrostek et al., 2013).

1. Chrostek E, Marialva M, Esteves SS, Weinert LA, Martinez J, Jiggins FM, & Teixeira L (2013) Wolbachia variants induce differential protection to viruses in Drosophila melanogaster: A phenotypic and phylogenomic analysis. PLoS Genetics 9(12).

2. Hamilton PT ...

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...ionship between these two organisms, as evidenced by the algae’s intracellular invasion into the embryo’s tissue. The specific details regarding this anatomical relationship are still unclear, mostly as a result of past failures to culture algae from the oviducts of pregnant salamanders (Kerney et al., 2011). Furthermore, it remains unknown how Oophila are able to locate spotted salamander eggs (Graham et al., 2012).

1. Graham E, Fay S, Davey A, & Sanders R (2012) Intracapsular algae provide fixed carbon to developing embryos of the salamander Ambystoma maculatum. The Journal of Experimental Biology 216(3): 452-459.

2. Kerney R, Eunsoo K, Hangarter R, Heiss A, Bishop C, & Hall B (2011) Intracellular invasion of green algae in a salamander host. Proceedings of the National Academy of Sciences of the United States of America 108(16): 6497-6502.

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