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Diabetes mellitus pathophysiology paper
Review of literature on diabetes
Diabetes mellitus pathophysiology paper
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Diabetes Mellitus(DM)
• Is a group of metabolic diseases in which a person has high blood sugar.
• An estimated 227 to 285 million people had diabetes in 2010, with type 2 making up about 90% of the cases. This is equal to 3.3% of the population with equal rates in both women and men. In 2011 it resulted in 1.4 million deaths worldwide making it the 8th leading cause of death.
• There are three types of Diabetes
• Type 1 – Insulin dependent, results from the body's failure to produce insulin. Also known as Juvenile diabetes.
• Type 2 – Insulin resistant, cells fail to use insulin properly, sometimes also with an absolute insulin deficiency. Also known as Adult onset diabetes.
• Gestational diabetes - occurs when pregnant women without a previous diagnosis of diabetes develop a high blood glucose level.
• History of Diabetes
• Clinical features similar to diabetes mellitus were described 3000 years ago by the ancient Egyptians. The term "diabetes" was first coined by Araetus of Cappodocia.
• The word mellitus (honey sweet) was added by Thomas Willis (Britain) in 1675 after rediscovering the sweetness of urine and blood of patients (first noticed by the ancient Indians). And then confirmed In 1776 by Dobson (Britain).
• In 1857 Claude Bernard (France) discovered an important milestone in the history of diabetes, the establishment of the role of the liver in glycogenesis, and the concept that diabetes is due to excess glucose production.
• In 1889 Mering and Minkowski (Austria) discovered the role of the pancreas in pathogenesis of diabetes. Later in 1921, this discovery constituted the basis of insulin isolation and clinical use discovered by Banting and Best (Canada).
• In 1955, Trials to prepare an orally administrated hypogly...
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...tion and some careers or positions don’t make that time accessible.
• Financial changes: It can be hard on a person financially to pay for the costs diabetes brings along with it. If you don’t have medical it can be expensive and if you do Co-pays can still be high. You need to pay for Blood monitoring equipment (Glucometer), test strips, medication and insulin. Life insurance may also be more difficult and more expensive, if you're even able to get it for someone with diabetes. Costs of a change in diet and memberships to the gym, or the purchase of exercise equipment, are all things that also need to be considered.
• Doctors and dietitians, counselors, or other specialists can help a person to adjust to their new life. Diabetes is a manageable condition, and it is well worth the time and effort to discover what will keep a person with Diabetes feeling their best.
Diabetes is a very serious disease that takes many lives each year. It is a lifelong disease that can be fatal to both adults and children if it is uncontrolled. Diabetes does not have to be fatal if certain precautions are taken. If diabetics maintain a healthy diet and watch their carbohydrate intake they can keep their diabetes under control. Monitoring blood sugar is also necessary to live a healthy life. If diabetics know the right way of maintaining their diabetes, they can live a very normal and active life.
The main economic impact of type 1 diabetes mellitus is the cost. It is believed that that in 2012 the cost of type 1 diabetes mellitus was around 245 billion dollar. This included 176 billion dollars in direct medical cost and 69 billion dollars in reduced productivity. Researches estimated that about 15.5 million people currently live with diabetes.
During the year 1889, two researchers, Joseph Von Mering and Oskar Minkowski, discovered the disease that is known today as diabetes. Diabetes is a disease in which the insulin levels (a hormone produced in unique cells called the islets of Langerhans found in the pancreas) in the bloodstream are irregular and therefore affect the way the body uses sugars, as well as other nutrients. Up until the 1920’s, it was known that being diagnosed with diabetes was a death sentence which usually affected “children and adults under 30.” Those who were diagnosed were usually very hungry and thirsty, which are two of the symptoms associated with diabetes. However, no matter how much they ate, their bodies wouldn’t be able to use the nutrients due to the lack of insulin.
In the Toronto Daily Star, they reported the discovery in an article called “Defeat of Diabetes Definitely Declared”. Although a short article this passage feels more like a propaganda piece then anything. The title itself sounds very war like and tells the readers the steps of how Banting and Best defeated diabetes. The article goes on to explain the steps that Banting and Best took in a positive light, denouncing any mistakes that the two men made before insulin was introduced to the world. The article stated “Doubtless this is a new beginning. The next thing will be, as anyone can can think for himself, that with this clue, biochemistry will discover why adrenal extract does not cure Addison’s disease…” This passage is important because Canada is building its confidence in the medical world. This miracle discovery is one which made every Canadian proud, even today, that they discovered something so important to every day lives of people who had diabetes they had to show off their proudness in their doctor’s skills to find a solution to the diabetic
The first evidence of diabetes was found on an early Egyptian manuscript from 1500 BCE, however; it is only in the last 200 years that we understand what is happening at the cellular level in a diabetic individual (Polansky, 2012). We now know that diabetes is a complex disorder of genetic, chemical, and lifestyle factors that contribute to the body’s inability to utilize glucose for energy and cellular functions (ADA, 2013).
Diabetes is a disease that affects the body’s ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy. Diabetes falls into two main categories: type 1, or juvenile diabetes, which usually occurs during childhood or adolescence, and type 2, or adult-onset diabetes, the most common form of the disease, usually occurring after age 40. Type 1 results from the body’s immune system attacking the insulin-producing cells in the pancreas. The onset of juvenile diabetes is much higher in the winter than in the summer. This association has been repeatedly confirmed in diabetes research. Type 2 is characterized by “insulin resistance,” or an inability of the cells to use insulin, sometimes accompanied by a deficiency in insulin production. There is also sometimes a third type of diabetes considered. It is gestational diabetes, which occurs when the body is not able to properly use insulin during pregnancy. Type 2 diabetes encompasses nine out of 10 diabetic cases. Diabetes is the fifth-deadliest disease in the United States, and it has no cure. The total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. Diabetes risk factors can fall into three major categories: family history, obesity, and impaired glucose tolerance. Minority groups and elderly are at the greatest risk of developing diabetes.
Most common people will see that they are suffering from type 2 diabetes. Unlike type 1 diabetes, type 2 is not because your immune system is attacking the insulin but is because your body simply does not produce the required insulin. 90% of people who have diabetes are diagnosed with type 2 (Medical News...
Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas plays an important role of the metabolism of glucose by means of secreting the hormones insulin and glucagon. These hormones where then secreted by Islets of Langerhans directly to the blood. Inadequate secretion of insulin results on impaired metabolism of glucose, carbohydrates, proteins and fats which then result to hyperglycemia and glycosuria. Hyperglycemia is the most frequently observed sign of diabetes and is considered the etiologic source of diabetic complications both in the body and in the eye. On the other hand, glucagon is the hormone that opposes the act of insulin. It is secreted when blood glucose levels fall.
Now that we have a general idea of how our body regulates sugar intake we can discuss exactly what diabetes is. It is a disease in which your body is unable to use glucose for energy, resulting in elevated blood glucose levels. There are a few different types of diabetes. In some cases, a person’s body does not make insulin at all. Thus, there is no insulin to tell your cells to use the glucose for energy. This is called type 1 diabetes, or it was previously known as juvenile diabetes. Only 5 to 10% of diabetes cases are diagnosed as type 1 (Grosvenor & Smolin, 93). It is usually discovered before a pers...
2. Type 2 on the other hand, results from the cell’s inability to use insulin appropriately (RCT).
...a healthy life. While they lived that healthy life, they have to be more responsible than a person without diabetes because anything could happen. Bottom line, society or life before the discovery of insulin was bad for a lot of people who had this sickness. So thanks to insulin life has changed then, now, and later.
Although diabetes can be genetic, that doesn’t necessarily mean you’re prone to get it. Controlling and checking your blood sugar helps to treat diabetes, as well as insulin therapy, regular check-ups/monitoring, and exercising. If you’re diabetic, you’ll find that at first, it’s frustrating and time consuming to treat for your diabetes. You’ll get the hang of it soon enough.
Gestational diabetes is a form of diabetes that occurs during pregnancy. Although it usually goes away after the baby is born, it does bring health risks for both the mother and baby. When you’re pregnant, pregnancy hormones make it harder for insulin to move glucose from your blood into the cells. If your body can’t produce enough insulin to overcome the effects of insulin resistance, you’ll develop gestational diabetes. (IHC, 2013)
Diabetes is a common disease, which can be a serious, life-long illness caused by high levels of glucose in the blood. This condition is when the body cannot produce insulin or lack of insulin production from the beta cells in the islet of Langerhans in the pancreas. Diabetes can cause other health problems over time. Eye, kidneys, and nerves can get damaged and chances of stroke are always high. Because of the serious complications, the purposes of teaching a plan for diabetes patients are to optimize blood glucose control, optimize quality of life, and prevent chronic and potentially life-threatening complications.
That is to say that “People with diabetes have high blood glucose, also called high blood sugar or hyperglycemia” (“Diagnosis”). In order to seek the proper care for diabetes, patients must undergo: distinguishing its symptoms, classifying if it is pre-diabetes or type 2 diabetes, and the proper treatment.