Vitamin A and Multiple Sclerosis
There is countless research that widely associates vitamin D and vitamin A in possibly decreasing adverse effects of multiple sclerosis (MS). Although, vitamin A is not as popular in research as vitamin D it has shown in certain trials to be beneficial to patients suffering from MS, but more commonly there is a positive link to vitamin A in animal trials of treating experimental autoimmune encephalitis (EAE) the animal version of MS, . Vitamin A is a fat- soluble vitamin that can function in immunological responses as well as brain development. This vitamin is crucial for vision, gene transcription, and bone metabolism (7). Vitamin A may help in MS by lowering inflammation as well as increasing the tolerance of autoimmunity, which refers to the immune system destructing healthy cells in the body (1). However, excess vitamin A can lead to problems or even death due to its potency of action in addition to difficulty in excretion, related to its solubility in lipids. Retinoic acid is one of vitamin A’s major metabolites that perform in functions related to the nervous system and the immune system (1).
Multiple Sclerosis is a debilitating disorder of the central nervous system (CNS), which is characterized by myelin sheath destruction, where myelin refers to the fatty covering that protects the brain and spinal cord (3). Myelin is essential since it serves as a high-speed transmitter for messages traveling to the brain and spinal cord. Therefore, myelin’s destruction leads to messages slowing down or being blocked, which leads to loss of function (4). The pathophysiology or cause of MS is currently not understood, nor is there a provided treatment for the disease, although environmental factors hav...
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...dendrocyte glycoprotein in patients with multiple sclerosis. Journal of Neurosciences in Rural Practice. 2012; 3 (3): 294-297.
4. University of Maryland Medical Center. Multiple sclerosis; June 2013. Available at: http://umm.edu/health/medical/altmed/condition/multiple-sclerosis. Accessed April 14, 2014.
5. Runia T, Hop, W, Rijke Y, Hintzen R. Vitamin A is not associated with exacerbations in multiple sclerosis. Multiple Sclerosis and Related Disorders. 2013; 3: 34-39.
6. Salzer J, Hallmans G, Nyström M, Stenlund H, Wadell G, Sundström P. Vitamin A and systemic inflammation as protective factors in multiple sclerosis. Multiple Sclerosis Journal. 2013;19 (8):1046-1051.
7. Torkildsen O, Loken-Amsrud KI, Wergeland S, Myhr K-M, Holmoy T. Fat-soluble vitamins as disease modulators in multiple sclerosis. ACTA Neurologica Scandinavica. 2013; 127 (196): 16-23.
The American Dietetic Association’s position statement on Nutrition and Athletic Performance, written in conjunction with the Dietitians of Canada and the American College of Sports Medicine, makes specific references to the effects of Vitamin D, both independently and in reference to other micronutrients who are influenced by Vitamin D within the body. The American Dietetic Association’s position statement also describes that Vitamin D is required for a myriad of functions within the body, which include adequate calcium absorption, regulation of serum calcium and phosphorous levels, promotion of bone health, and regulation of homeostasis and development of the nervous system and skeletal muscles 1.
Multiple sclerosis (MS) is a disease affecting the myelination of the central nervous system, leading to numerous issues regarding muscle strength, coordination, balance, sensation, vision, and even some cognitive defects. Unfortunately, the etiology of MS is not known, however, it is generally thought of and accepted as being an autoimmune disorder inside of the central nervous system (Rietberg, et al. 2004). According to a study (Noonan, et al. 2010) on the prevalence of MS, the disease affects more than 1 million people across the world, and approximately 85% of those that are affected will suffer from unpredictably occurring sessions of exacerbations and remissions. The report (Noonan, et al. 2010) found that the prevalence of MS was much higher in women than in men, and that it was also higher in non-Hispanic whites than in other racial or ethnic groups throughout the 3 regions of the United States that were studied.
Brownstein, Joseph. “Some common vitamin supplements could increase death risk, study finds.” 10 October 2011. Vitals on mnsbc.com. Web. 11 January 2012. http://vitals.msnbc.msn.com/_news
Around the world, many people are living with neurologically debilitating disorders like multiple sclerosis. Multiple sclerosis is best described as a pathological “inflammatory-mediated demyelinating disease of the human central nervous system,” and affects more than 2.5 million people globally (Trapp & Nave, 2008).
According to National Multiple Sclerosis Society, Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain and body. The central nervous system (CNS) comprises of the brain and the spinal cord. CNS is coated and protected by myelin sheath that is made of fatty tissues (Slomski, 2005). The inflammation and damage of the myelin sheath causing it to form a scar (sclerosis). This results in a number of physical and mental symptoms, including weakness, loss of coordination, and loss of speech and vision. The way the disease affect people is always different; some people experience only a single attack and recover quickly, while others condition degenerate over time (Wexler, 2013). Hence, the diagnosis of MS is mostly done by eliminating the symptoms of other diseases. Multiple sclerosis (MS) affects both men and women, but generally, it is more common in women more than men. The disease is most usually diagnosed between ages 20 and 40, however, it can occur at any age. Someone with a family history of the disease is more likely to suffer from it. Although MS is not
Arthritis affects people of all age groups. More than 100 types of arthritis are known. Among these osteoarthritis and rheumatoid arthritis having the highest incidence. One of the major causes of chronic debilitation in industrialized nations is Osteoarthritis which results from damage to the joints, which may be due to trauma, infection, or age-related wear. Rheumatoid arthritis is encountered less frequently than osteoarthritis and is estimated to affect around one per cent of the world’s population. Amongst patients of Rheumatoid arthritis, women are three times more likely to be affected by this condition than men. This condition is caused by an inflammatory process where the body starts attacking itself. Rheumatoid arthritis also affects several joints, with inflammation sometimes seen in and around the lungs, the heart, the eyes and the skin. The most commonly reported complaint by arthritis patients is pain. The pain might be from the joint itself and be a result of inflammation, damage from the disease, or through daily wear and tear. Muscle pain is also common and is caused by having to force movements against stiff and painful joints. Although range of movement in the affected joint may be limited and uncomfortable, physical exercise has been shown to benefit those with arthritis. Physical therapy has been shown to significantly improve function, decrease pain in the long term and delay the need for surgery in advanced cases. The majority of arthritis cases occur among theelderly, however the disease can occur in children as well. Over 70% of the population that get affected by arthritis in North America are over the age of 65 (4). The disease occurs more commonly in females than males in all races, age groups, and ethn...
Multiple Sclerosis (MS) is a complicated chronic deteriorating disease that has an effect on the central nervous system (CNS). This disease causes destruction of the myelin around the nerve fibers. “The exact etiology of Multiple Sclerosis is unknown; however, it is thought to be an immune mediated disease. MS is characterized by CNS inflammation, demyelination, and axonal loss” (Compston & Coles, 2008). Typically, it is described by early relapses and remissions of neurological signs of the CNS. This is known as relapsing-remitting MS (RRMS). MS can be identified by a variety of known risk factors. Multiple Sclerosis can be brought on by a mixture of inherited and environmental risk factors such as smoking or an exposure to a virus like Epstein Barr. The inflammatory process has an interesting role on the central nervous system.
Wiley Online Library, 2013. The Epidemiology of Multiple Sclerosis [online] Available at: <. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1997.tb08143.x/abstract> [Accessed 05 December 2013].
Multiple sclerosis is a chronic inflammatory autoimmune disease of the central nervous system, directed against the myelin sheath. Leading to demyelination and axonal loss. It’s characterized by spread “plaques” of demielinization typically found in typically found on MRI in the periventricular region, corpus callosum, centrum semiovale and, to a lesser extent, deep white – structures and basal ganglia.(Olek, 2005)
Multiple Sclerosis has been categorized into four different subtypes according to the distinct neuropathological changes accompanying the disease (Antony, DesLauriers, Bhat, Ellestad & Power, 2011).
Multiple sclerosis, also known as MS, is one of the humankind’s most mysterious diseases. Multiple sclerosis has the ability to affect nearly 3 million people worldwide. This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men are. Of those 3 million people, most of them are between the ages of 20 and 50 years old. Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.
Multiple Sclerosis is a nervous system disease that affects the spinal cord and the brain by damaging the myelin sheaths that protects nerve cells. Destroyed myelin prevents messages from communicating and sending properly from the brain, through the spinal cord, to internal body parts. In the United States, more than 350,000 people are diagnosed with this disease. Anyone can get this disease, but it is more common among Caucasian women. MS symptoms begin between the ages 20-40 and are caused by nerve lesions being present in multiple areas of the Central Nervous System, symptoms differ on the lesion’s location.
The research into the effect Vitamin A has on Alzheimer’s disease needs to be furthered. One avenue to further it would be examining retinoic acids in vivo. This would allow the retinoid mechanisms of action and their receptors in Alzheimer’s disease to be better understood. Another method to further research would be to study the affect retinoic acid has on amyloid β in Alzheimer’s disease using different techniques, such as histopathological observation.
Medicine.yale.edu. (2014). Amyotrophic lateral sclerosis (als) > neurology | yale school of medicine. [online] Retrieved from: http://medicine.yale.edu/neurology/divisions/neuromuscular/als.aspx [Accessed: 9 Jan 2014].
...t one has it. Many scientists hypothesize that there is an inflammatory response in the brain when there is an extensive B-42 amassing. To slow or stop this, scientists theorize that the use of anti-inflammatory drugs, such as aspirin, could delay the swelling in the brain. Also, as scientists have known that taking a multi-vitamin tablet each day is good for you, there has been recent research demonstrating that the use of antioxidants may protect neurons, not just the immune system and keeping the body healthy by providing vitamins and minerals. These special supplements protect the neurons from the effects of the accruing B-Amyloid that would likely cause the plaque that causes AD.