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Huntington's Disease
Huntington's Disease (HD) is a dominant genetic disorder. Each child of a person who has HD has a 50% chance of inheriting the disease, and the disease does not skip a generation. HD is caused by a larger than normal CAG repeat in the Huntington gene. This larger than normal CAG repeat produces an abnormal protein that begins to kill brain cells when the person who has the gene reaches middle age. The loss of these cells causes intense symptoms and eventually death.
HD was named after Dr. George Huntington. In 1872, he was the first person to document an accurate description of the symptoms and course of the disease. At the time he called it “hereditary chorea”. The Huntington gene was discovered in 1993 by the Huntington Study Group. The CAG repeats in the Huntington gene, which is located on chromosome 4, code for the protein huntingtin. The larger than normal number of CAGs in a person with HD causes the huntingtin protein to be abnormal, which leads to symptoms. Even though every cell in the body has the gene, only the cells in the brain seem to be affected.
A person has two alleles for every gene. One allele is inherited from the mother and one allele is inherited from the father. If either allele of the Huntington gene has the larger than normal CAG repeat, the person will have HD. If neither allele has the larger than normal CAG repeat, the person will not have HD and will not pass it on. When a person has children, only one allele of each gene is passed on. If a person with HD passes on the allele with the larger than normal CAG repeat, the child will have HD. If the allele with the normal CAG is passed on, the child will not have HD.
Early signs of HD are mood swings, irritability, depression, memory loss, and uncontrolled movements. As the disease progresses, it becomes more difficult to walk and speak. Also, memory and intellectual functions continue to decline.
A person who has a chance of inheriting HD can be tested any time after they reach the age of 21. Testing for the HD gene entails a blood sample genetic test that analyzes DNA for HD mutation by counting the number of CAG repeats in the HD gene region. A person will not get HD if their CAG repeats are lower than 30.
...d hard times as an African American woman venturing positions no other African American woman has achieved. She achieved much of her fame from her talk show, The Oprah Winfrey Show, but her success did not stop there. As the founder, chairman, and CEO of Harpo Entertainment Group, Oprah Winfrey became one of the most powerful women in the entertainment production industry. Not only is she a powerful entrepreneur, but also a charismatic interviewer who has captured the hearts of many Americans. She had the courage to follow her intuitions and the perseverance to see the project through. Oprah has impacted others on her genuine care to give back to various charities. Oprah continues to take on more projects to expand her growing company. Oprah Winfrey is a powerful figure in society who will continue to be an inspiration to people of all backgrounds around the world.
The major costs of working in the funeral industry are for those that own their own funeral home. The average funeral home handles about 100 calls per year and has around three full-time and three part-time employees. So, there is a difference in wealth between the full-time and part-time employees and difference between those that own their own funeral home against those that just work at a funeral home.
1 in 1000 to 1 in 10,000 peoples around the world and, 4-10 per 100000 in the western countries are affected with HD. The average age of onset is 40 years and disease progresses over 15-20 years. The earliest symptoms include general lack of co-ordination, uncontrollable jerky movements called chorea and slow saccadic eye movements. As the disease progresses cognitive abilities are declined and finally leading to dementia along with behavioural and psychiatric problems [3]
It is estimated that between .1 and 10 % of people who suffer from Huntington's
Lennon impacted many around the world , his music and messages gave people an alternative outcome to the controversy of the Vietnam war. As Middleton stated people even suggested that “a major wold figure had died”. Rooney claims that “His impact remains universal, his influence undiminished”(349). This clearly proves John Lennon had a stong impact on the world.
The HD gene is present at birth, but doesn't usually develop until a persons thirties or forties. Though this is the most common time for symptoms to develop, there have been cases were symptoms developed as young as 2 and as old as 80. Symptoms begin gradually and increase over time.
Huntington’s disease is named after George Huntington. This disease genetically is an inherited disorder that damages the mind and nervous system. This may affect actions of the body for example like movement, the ability to reason, awareness, and thinking and judgment. It can also affect their behavior. The word genetic is that the disorder is delivered on by each generation of offspring by special codes called genes(Patient.Co.Uk, 2011). Genes are relocated from a parent to offspring and is held to decide some characteristics of the children (Patient.Co.Uk, 2011).
To overcome the ordeal, Oprah explained that she had t believe in a power greater than herself. “She also said in the discussion with Letterman that she spent much of her life attempting to rebuild her self-esteem. In the end though, Oprah overcame poverty, parental neglect, sexual abuse, and racism to become one of the richest and most powerful women in the entertainment industry.
What is the Great Depression, you ask? Well, the Great Depression is basically an economic-meltdown caused by uneven distribution of income. In the late 1920s, not enough people could afford to purchase goods because of the way money was being distributed. The economy was greatly upset by this and as a result, farmers in the rural, Southern parts of America, such as Alabama, were in distress because less people were buying their products. This issue was also raised in Lee’s novel through characters like the Cunninghams- a family of local farmers who were hit hard by the Great Depression and became so poor the only way they can repay their debts is through home-grown crops.
Miller, Marsha L. “HD Research – Past and Future.” Huntington’s Disease Society of America. 2011. Web. 23 March 2012.
Oprah Winfrey is an African American woman who is known as a U.S. media celebrity. She has done so much to contribute to society as we know it and her legacy will forever live on. Mrs. Winfrey is well known and she uses her platform for positivity and love, which is a huge reason for her success. She is an intelligent leader who worked hard for the spot she has in life and strives to encourage others to be successful also. Mrs. Winfrey has written books, acted and produced films, hosted an infamous television show, and given to charities. Her hard work and dedication has made her one of the most influential women of all time. She strived for greatness and accomplished what she wanted out of life, despite various obstacles that had been in the
John Lennon’s effect on the world was brilliant and his legacy still lives on. All throughout his time he accomplished many things, and definitely made the world a better place. With the music, the peaceful things he did, and everything in between. His message was peace, love, and happiness. Lennon was brilliant and deserves more credit than what he gets. He left an impact that changed the world.
Many controversies have arisen nowadays as to whether international law is “natural law”, international law now faces considerable criticism as to its effectiveness as law and doubts as to its actual existence, and its power to bind countries .
Public International law International law contains of rules and principles, which preside over the relations and communication of nations with each other. International Law that is in most other countries referred to as Public International Law concerns itself only with questions of rights among more than a few nations or nations and the citizens or subjects of other nations. In dissimilarity, Private International Law deals with controversies among confidential persons, natural or juridical, arising out of situations having important association to further than one nation. In current years the line up connecting public and private international law have became more and more doubtful. Issues of private international law may also associate issues of public international law and numerous matters of private international law nave considerable meaning for the international group of people of nations. International Law consists of the basic, classic concepts of law in nationwide legal systems, status, property, responsibility, and tort. It also includes substantive law, procedure, process and remedies. International Law is rooted in receipt by the nation states, which comprise the system. Customary law and conventional law are primary sources of international law. Customary international law results when states trail convinced practices usually and time after time out of an intelligence of legal responsibility. Lately the customary law was codified in the Vienna Convention on the Law of Treaties. Conventional international law derives from international agreements and may obtain any appearance that the constricting parties have the same opinion upon. Agreements may be complete in admiration to any substance except for to the leve...
The international law is the fundamental basis of sovereignty and equality of all states. It promotes peace, order, and justice to the international society. The effectiveness of the international law is also anchored to the international community whether they will follow or not. It is important that international community has rules and obligation to follow in order to prevent chaos in the society. The development of international law led to the understanding of different policies and sanctions for the states. It deals with conflict of the states to relieve destructive conflict. The international law is agreed upon by the international community but there is no enforcing body unlike in the domestic law. State has been relying to treaties and international agreements for the prevention of war.