Is the Colt .45 Obsolete?
Can the Model 1911 Colt .45 Autos still hold their own in today’s market of newfangled high tech guns? The 1911’s have faithfully served our country from 1911 to 1983 without any changes being made to the original design, and only minor modifications were incorporated then, such as an automatic firing pin locking safety and a redesigned half-cock notch. It is a proven design and there is nothing newfangled about it.
Colt Firearms had a long and profitable relationship with John Browning, which included his machine guns as well as the world-famous Colt .45 automatic pistol. In 1899, John Browning had devised an auto-loading pistol using a locked-breech, tilting-barrel design and chambering a powerful .38 auto pistol cartridge. The army wasn’t interested in a .38 caliber pistol; instead, because of its effective stopping power, the next pistol was to be of the .45 caliber. Using Browning’s inventive genius, Colt, with the help of John Browning and the U.S. Army, produced the timeless .45 Auto Government Model of 1911.
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The United States adopted the caliber .45 Browning-designed Colt automatic pistol in 1911. All manufacture of this pistol was originally carried on at Colt, but Springfield Armory was tooled to produce the weapon by 1914. At the time of United States entry into World War I, 55,553 pistols were on hand. During World War I, Model 1911 pistols were manufactured by Remington Arms and Colt,… Approximately 450,000 Model 1911 pistols were made during World War I by Colt and Remington. Colt was by far the largest producer;…
To this day the 1911,s are still in service with U.S. Armed Forces, police agencies and some very elite units, most notably the LAPD SWAT Team. Since the beginning of its career when the Military adopted the pistol in 1911, it has proved itself a fine fighting handgun. The Colt 1911 has seen action in all the major conflicts of the 20th Century from WWI, WWII, Korea and Vietnam to Desert Storm. Many of the 1911,s from WWII are still in active service today.
To clarify matters, when I refer to the ”Colt 1911” or “1911”, I am not only referring to the original1911, but also all subsequent modifications and developments as well, including the 1911A1 in commercial and military trim, the Commanders, the assorted copies and clones…to be short, all pistols based on the original Government Model of 1911.
Bordetella pertussis is a highly communicable agent and is transmitted person-to-person via airborne droplets or direct contact with discharges from the respiratory mucous membranes of an infected person. This small, gram-negative coccobacillus is non-motile, aerobic and fastidious. B. pertussis colonizes the respiratory tract including the mouth, nose, throat and beginning of the lungs of young children worldwide. The bacteria bind to ciliated cells in the respiratory mucosa by producing adhesions. Filamentous hemagglutinin on the cell surface and pertussis toxin (Ptx) both help the bacteria in binding. Filamentous hemagglutinin binds to the galactose residues on the glycolipid of the ciliated cells. Ptx, in its cell-bound form, binds to the glycolipid lactosylceramide, which is also found on the ciliated cells. Ptx binds to the surface of phagocytes as well, causing phagocytosis of the bacteria. This mechanism may lead to enhanced survival as an intracellular parasite. Adding to its many purposes, Ptx deregulates the host cell adenylate cyclase activity. The A subunit of this AB toxin, affects the G protein responsible for inhibiting adenylate cyclase. This leads to an increase in cyclic adenosine monophosphate (cAMP) creating detrimental metabolic changes in the host cells.
For the disease to occur, Bordetella pertussis evades the host immune system and is disseminate in the lower respiratory tract. Inhaled bacteria droplets then attach to the ciliated epithelial cells in the nasal-pharynx and trachea. It is at this point that Bordetella pertussis produces virulent factors that are classified into two; adhesins and toxins. Adhesins mediate bacterial attachment to the epithelial cells while toxins that mediate the host immune system. Adhesins include; filamentous haemagglutinin, fimbriae and pertactin while toxins include pertussis toxin, tracheal cytotoxin and adenylate cyclase toxin(1). To understand the role of these virulence factors in whooping cough disease, a mouse model has been used (2).
For years now, the healthcare system in the United States have managed patient’s health records through paper charting, this has since changed for the better with the introduction of an electronic medical record (EMR) system. This type of system has helped healthcare providers, hospitals and other ambulatory institutions extract data from a patient’s chart to help expedite clinical diagnosis and providing necessary care. Although this form of technology shows great promise, studies have shown that this system is just a foundation to the next evolution of health technology. The transformation of EMR to electronic heath record system (EHR) is the ultimate goal of the federal government.
Heathcliff cried vehemently, "I cannot live without my life! I cannot live without my soul!" Emily Brontë distorts many common elements in Wuthering Heights to enhance the quality of her book. One of the distortions is Heathcliff's undying love for Catherine Earnshaw. Also, Brontë perverts the vindictive hatred that fills and runs Heathcliff's life after he loses Catherine. Finally, she prolongs death, making it even more distressing and insufferable.
B. pertussis has several virulence factors, mainly involving proteins that have been separated into 2 main classifications: adhesions and toxins. The adhesions category consists of the following: filamentous hemagglutinin (FHA), fimbriae (FIM), and pertactin (PRN). FHA is a very large surface protein, and it works to help B. pertussis attach to the host cell. FIM are surface appendages, a common finding in other bacteria. However, these appendages contain a factor called agglutinogens, which is used to serotype this bacteria.1 PRN has shown to take on a defense role, fighting any neutrophils that may come to the rescue. As stated above, the other classification of B. pertussis virulence factors is toxins, and it composed of adenylate cyclase toxin (ACT), pertussis toxin (PT), and tracheal cytotoxin (TC). ACT is actually quite an important virulence factor for this bacteria. It functions by injecting itself into the host cell, where it increases cAMP rates. This causes phagocyte function to cease, and may trigger apoptosis in selected cells.1 The exact role of PT is not yet fully understood, but it has come...
Today students do not have the money for their tuition. Tuition goes up every year. Also the fees such as student or orientation fees went up as well. Students shouldn’t be in debt for their education. Students should be able to have a good education so they coul...
Literature has shown there is a constructive correlation between an individuals socioeconomic status (SES) and their participation in sporting activities. This piece of writing will be defining the impact social class division has on the opportunities for an individual to participate in sport and leisure activities. Also the key aspects of the social class system within the United Kingdom, from the traditional methods of social stratification, to the modern 7 class system released in 2013 by the British Broadcast Corporation (BBC). The term 'Social Class' or 'Socioeconomic Groups' , refer to an individuals status within society. There are various factors which determine an individual's status, such as; income, family background and educational experiences. This socioeconomic status can be seen as a status hierarchy in which three main common social classes are informally accepted in the majority of societies: Upper Class, Middle Class and Working Class (Wesson et al, 2000).
The bacterium Bordetella Pertussis causes Pertussis also known as the whooping-cough. This is an extremely contagious respiratory tract infection which causes the lining of the air way to become inflamed and damaged. This leads to an excess production of mucous which irritates the respiratory tract and causes the cough element of the disease. Pertussis can cause other serious illnesses and is usually spread through coughing or sneezing while in close contact with other people who then breathe in the bacteria causing disease. You can get Pertussis more than once sometimes even years apart at any age. If you have not completed the primary vaccination series you are at higher risk for severe illness. “Since the 1980’s, the number of reported Pertussis cases has gradually increased in the United States. In 2005, over 25,000 cases of Pertussis cases were reported in the United States, the highest number of reported cases since 1959. Approximately 60 percent of the cases were in adolescents and adults, a result of decreasing immunity in this population” (Department of Health, n.d.).
Haven, Charles T. and Frank A. Belben. A History of the Colt Revolver. New York: Bonanza
This is reflected by the demands for more serology testing, which the method of confirmation in adolescents as well as adults who typically present with milder features later in the course of the sickness. However, failing immunity following vaccination as well as natural infection is also likely to be an important factor. This increased activity has continued through the first quarter of 2012 and has extended into three month of infant age. Although a greater number of cases are being confirmed in older age groups, the incidence in these age groups remains relatively low. The name of the virus is called Pertussis, or whooping
the respiratory system. This disease is caused by the the bacterium, Bordatella pertussis, which transfers from person to person through air droplets. Coughing, sneezing, or coming close into contact with an infected person can be very dangerous it is likely to infect a healthy person. Once Bord atella pertussis enters a person’s system, it sticks itself to the cilia in one’s respiratory system. Because the bacteria releases toxins once it binds to the cilia, the cilia gets damaged and begins to swell up the person’s airways.
Whooping cough is a vaccine-preventable disease caused by the bacterium Bordetella pertussis and Bordetella parapertussis. Despite having an available vaccine, cases of whooping cough in the United States and around the world have steadily increased since the 1980s, especially among infant and adolescent age groups. In recent years, 2012 had the highest number of cases since 1955. The number of cases have since decreased however, the Centers for Disease Control and Prevention (CDC) noted a 15% increase in cases between 2013 and 2014 (“Pertussis Outbreak Trends”).
Root crops are the edible energy–rich underground plant structures developed from modified roots. While tuber crops are those crops in which the edible carbohydrate – rich storage organs develop wholly or partly from underground stems (Okigbo 1989). Root crops and tuber crops are important in Sub Saharan Africa, Latin America and the Caribbean. Some of the major root tubers crops grown are cassava, yams, sweet potatoes and taro (dasheen). Flour made from the root crops can be partially substituted for wheat flour in the production of bread, cakes and pastries (Arenillo et al, 2012; Mongi et al, 2011; Okorie and Onyeneke, 2012;Rangel et al, 2011; Njintang et al 2008).
control systems in their games in order to help concerned parents limit their child’s playtime.
It also can improve their accuracy of diagnoses and health outcomes and improve care coordination through the efficiencies of practices.