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ethical issues in genetic research
essays on the human genome project
ethical issues in genetic research
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So what is a human genome and why is the government researching it? The Human genome is the sequence of roughly 20,000 genes that make up human Deoxyribonucleic acid (DNA), or the building blocks that tell cells what to do. The government project named Human Genome Project (HGP) started in 1990’s, and is trying to unravel the 3 billion chemical base pairs in a DNA strand (http://www.ama-assn.org/ama/pub/physician-resources/medical-science/genetics-molecular-medicine/current-topics/human-genome.shtml.)
DNA is made up of phosphates, sugars and amino acids, Adenine (A), Thymine (T), Cytosine(C) and Guanine (G). Each amino acid is paired with its opposite, A is always paired with T and C with G. These pairing in a specific order make codes that cells use as instruction for making proteins that perform specific functions in cells. The purpose of the HGP is to identify all genes in human DNA, store the information in a database, while improving the tools used to sequence DNA (Toriello, pg 15-28.) The project also has to deal with the ethical issues that come from these experiments. In 2003 after 13 years a full strand of DNA was decoded. Of course each person’s DNA is unique, with the exceptions of identical twin, so much more work is yet to be done to make this technology useful in every day life.
Once a DNA strand is sequenced there are many ways to use the information found in it. One possibility is to find what genes influence the development of diseases, like cancer, deformities, or Alzheimer’s, only to mention a few. If you know you have the gene on chromosome 19 that is linked with Alzheimer’s, there may be ways to treat the disorder early, slow its progress, or even prevent it. At the very least the family can prepare for th...
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Works Cited
Puck, Jennifer, Malech, and Harry. National Human Genome Research institute, Genetics and Molecular Biology Branch. Jan 31, 2006. Jan 1, 2010. https://www.123HelpMe.com/view.asp?id=154080.
Human Genome. 1995. American Medical Association. Jan 1, 2010. http://www.ama-assn.org/ama/pub/physician-resources/medical-science/genetics-molecular-medicine/current-topics/human-genome.shtml
Carroll, Sean. The making of the fittest. New York: Julia Druskin, 2006.
Nicolson, Cynthia. Baa. Toronto: Kids Can Press Ltd, 2001.
Gralla, Jay. Understanding Cloning. Indianapolis: Marie Butler-Knight, 2004.
Walker, Richard. Genes & DNA. Boston: Kingfisher, 2003.
Toriello, James. The Human Genome Project. New York: Rosen Publishing Group, 2003.
Fridell, Ron. Genetic Engineering. Minneapolis: Lerner Publications Company, 2006.
The PBS documentary “Nova – Cracking Your Genetic Code” tells about the genome sequencing technology: its current possibilities, advantages, disadvantages and future potential. The system became cheaper, faster and more available since the first human genome was fully sequenced in 2000. Modern companies use the technology to provide clients with the information about their genes and impacts they can have on owners’ health. Hospitals can provide more accurate diagnosis and personalized treatments with the aid of the genome sequencing. The video shows several examples of these benefits. But it mentions concerns about the quality of services, risks of exaggerated
DNA is the blueprint of life from its creation to its development and until its death. The discovery of the structure of DNA not only revolutionized science and medicine, but it also affected many other facets of existence: evolutionary, industrial, legal, and criminal justice. Its incarnation has benefitted American families and industries and spurred scientific innovation throughout the country. Aptly stated by Francis Crick, “your joys and your sorrows, your memories and your ambitions, your sense of identity and freewill, are in fact no more than the behavior of a vast assembly of nerve cells and their associated molecules. As Lewis Carroll’s Alice might have phrased it: ‘you’re nothing but a pack of neurons.’ [Watson and my] discovery illustrates how that is possible.”
The more we know about genetics and the building blocks of life the closer we get to being capable of cloning a human. The study of chromosomes and DNA strains has been going on for years. In 1990, the Unites States Government founded the Human Genome Project (HGP). This program was to research and study the estimated 80,000 human genes and determine the sequences of 3 billion DNA molecules. Knowing and being able to examine each sequence could change how humans respond to diseases, viruses, and toxins common to everyday life. With the technology of today the HGP expects to have a blueprint of all human DNA sequences by the spring of 2000. This accomplishment, even though not cloning, presents other new issues for individuals and society. For this reason the Ethical, Legal, and Social Implications (ELSI) was brought in to identify and address these issues. They operate to secure the individuals rights to those who contribute DNA samples for studies. The ELSI, being the biggest bioethics program, has to decide on important factors when an individual’s personal DNA is calculated. Such factors would include; who would have access to the information, who controls and protects the information and when to use it? Along with these concerns, the ESLI tries to prepare for the estimated impacts that genetic advances could be responsible for in the near future. The availability of such information is becoming to broad and one needs to be concerned where society is going with it.
The debate over the importance of a Human Genome Project can be cleared up by looking at what the human genome actually is, and why knowing its DNA sequence can be beneficial to the scientific and the human community. The human genome is made up of about three billion base pairs, which contain about 100,000 genes. The 100,000 genes in the 46 human chromosomes only account for a small total of the DNA in our genome. Approximately 10 percent of our DNA make up these genes in our genome, these genes are what is actually encoded for and used by our body to make vital proteins needed for everyday life. The remaining 90 percent of our three billion base pairs are repeated sequences between genes that do not encode for any particular product. These repeated sequences account for the reason why 99 percent of any humans DNA is identical to another human's (1). With this knowledge many people believe it is not worth the time or money to sequence the entire human genome when only a small percent is used to encode for proteins. However, by sequencing the whole genome researchers will no longer have to do a needle in the haystack type of search for small genes, like the one found on chromosome four that is responsible for Huntington's disease (4). Also, knowing the complete human DNA sequence will allow scientists to determine the role and importance of the repeated DNA, non-protein encoding, sequences in our body.
In 1990, the first great stride of genetics took place. This was called the Human Genome Project, a large-scale operation that was designed to understand the human genome (genetic structure). Since its commencement, there have been many leaps and bounds that have taken place. For certain genetic issues that we once knew nothing about, we no...
Genomics and the Human Genome Project are having huge positive effects on the economy of many places like China, Germany, France, Spain and many more. The Human Genome Project has brought in over $800 million dollars since 1990 and given about 4 million jobs since 2003 which has enabled m...
The purpose of the human genome project was to select the best pairs of the genes and the desirable characteristics in the human beings to maintain the production of the organisms according to the desirable gene sequencing. This project was initiated to control the sequencing of the gene artificially [1]. The world’s largest biological plan was the human genome project as it was started on the large scale. The idea of this project was given by the researchers in 1984. The practical work started in 1990 to execute the project. The official declaration of the project carried out in 2003. The financial assistance was awarded to the program setup through the healthcare workplaces, where their engagement was significant. Another program
The genetic technology revolution has proved to be both a blessing and a blight. The Human Genome Project is aimed at mapping and sequencing the entire human genome. DNA chips are loaded with information about human genes. The chip reveals specific information about the individuals’ health and genetic makeup (Richmond & Germov 2009).The technology has been described as a milestone by many in that it facilitates research, screening, and treatment of genetic conditions. However, there have been fears that the technology permits a reduction in privacy when the information is disclosed. Many argue that genetic information can also be used unfairly to discriminate against or stigmatize individuals (Willis 2009).
Over 60 countries now have operating genetic databases that contain millions of people’s genetic information. There DNA is used for genetic studies and to identify genetic similarities in a family. This DNA can also be used to identify the perpetrator in a crime by comparing their DNA to the DNA found at the crime scene. But as gene banks have become more common around the world some have grown to question the sharing of this information internationally and the potential for hacking and abuse of the information.(yg, 2015) Gene banks have opened doors to many genetic discoveries, but they have constantly raised ethical questions pertaining to the privacy of one’s biological information and that the information could lead to potential discrimination.
Marshall, Elizabeth L. The Human Genome Project: Cracking the Code within Us. New York: F. Watts, 1996. Print.
The Human Genome Project , or HGP, was created to help develop new and better tools for making gene hunts faster, cheaper, and practical for almost any scientist. The tools created by this project included genetic maps, physical maps, and DNA sequence maps. The greatest achievement of the HGP was their success in sequencing the entire length of human DNA, referred to as the human genome. With the sequencing of the human genome complete, HGP was able to go on to sequence the genes of several key organisms, like mice, mosquitos, and plants like mustard weed and rice.(Figure 1) The simplicity of the genetic structure of these organisms makes them perfect for future technology development. (DNA Sequencing)
The structure of DNA was discovered in 1953 and revealed to the world by James Watson and Francis Crick.1 Since then, there has been a whirlwind of activity and discovery in the fields associated with DNA. We have found that DNA is not only a set of instructions for the body, but that it also contains a lot of information about the individual who “owns” the DNA. As it is rapidly becoming cheaper and easier to process DNA, it is becoming more difficult to make sure that there is adequate legislature to protect members of society.
This is the outstanding achievement not only of our lifetime, but of human history. I say this, because the Human Genome Project has the potential to impact the life of every person on this planet. It is a giant resource that will change mankind, much like the printing press did.
Completed in 2003, the Human Genome Project is an extraordinary international scientific collaboration to decipher human genetic code. The decoding of human DNA sequence provides us a sketch of the entire human genome information. Today scientists can determine the complete DNA sequences of 25,000 human genes and access this information with a simple 30 second search. Using this genetic reference, we will advance our kno...
Human genome project is the biggest example of DNA sequencing. When the human genome was sequenced back in 2001, many issue rose but now after many year, we can see its impacts on medical and pharmaceutical research. Scientists are now able to identify the genes which are responsible for causing genetic diseases like Alzheimer's disease, Cystic fibrosis, myotonic dystrophy and many other diseases caused by the disability of genes to function properly. Many types of acquired diseases like cancers can also be detected by observing certain genes.