The Pesticide Called Atrazine Acts as an Endocrine Disruptor Promoting Demasculinization and Feminization in Amphibians

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The article reviewed in this summary is
Hayes, T.B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., and Gallipeau, S. 2010. Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proceedings of the National Academy of Sciences 107: 4612-4617.
The authors have assigned key words described throughout this article including amphibian decline, endocrine disruption, pesticide and sex reversal. The larger or global context for the research conducted in this article is that the pesticide Atrazine is widely utilized across the entire world, contaminating water sources by mobilizing through rainfall, disrupting habitats and impacting organisms by acting as an endocrine disruptor. The research specifically described in this article is how continued Atrazine exposure affects the reproductive development of a male population of African clawed frogs. This research explores the issue of atrazine exposure contributing to the generation of sex reversed frogs in a male population. The article addresses previous studies where Atrazine had no significant effects on amphibians in specific conditions. It also includes other studies where this pesticide proved to be an endocrine disruptor; reducing testosterone and promoting demasculinization and feminization in amphibians.
Atrazine exposure is a worldwide issue, but the geographical area used to collect the amphibians used for this research was in Tecalote Creek in San Diego County. The types of data used in this research include larynx structure or development, presence of visible nuptial pads and breeding gland size, testosterone levels, spermatogenesis, aromatase expression, matin...

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...o states another important finding that the decreased fertility and competition for mates indicates that endocrine disruptors may affect population levels and lead to declines in amphibians.
The reference list of this article includes 54 references. The reference cited most often throughout the article is reference number 10,
Hayes et al. 2002. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proc Natl Acad Sci USA 99: 5476–5480.
Prior to reading this article there were many words I was unfamiliar with. These words include aromatase which is an enzyme involved in the production of estrogen by converting testosterone to estradiol, nuptial pads which is a sex characteristic found on the hands of male amphibians and larynx, an organ located in the neck which contains the vocal chords.

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