Radiation-Induced Bystander Effect (RIBE) Essay

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Background: Radiation-induced bystander effect (RIBE) is defined as a phenomenon that occurs when radiation signals are transmitted from irradiated cells to non-irradiated ones, inducing radiation effects in them. RIBE has an effective role in radiation response at low doses as well as in radiotherapy due to affecting normal tissues adjacent or far from the irradiated tumor. Reactive oxygen species have an important role in RIBE induction; therefore, the present research was conducted to investigate the possible inhibitory effects of garlic as an antioxidant-containing plant on RIBE.
Materials and Methods: MCF7 cells treated with raw garlic extract were irradiated by 60Co gamma rays, and their culture medium was transferred to autologous non-irradiated (bystander) cells. Percentage cell viability and micronucleus formation in both irradiated and bystander cells were examined, and were compared with corresponding cell groups not treated with garlic.
Results: Treatment with garlic extract reduced the number of cells containing micronucleus in both irradiated and bystander cells. However, it only increased the percentage cell viability in bystander cells and not irradiated ones.
Conclusion: RIBE was effectively suppressed by raw garlic. Inhibitory effects of raw garlic may be of particular importance for exposures to environmentally relevant low doses, and partially for addressing the limited therapeutic gain of radiotherapy. Therefore, raw garlic is recommended in human diets, and should be prescribed for radiotherapy patients.

Key words: Allium sativum, Antioxidant, Radiation-induced bystander effect, Raw garlic

Ionizing radiations interact with organic compounds and water in the cells. Interaction between ra...

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...ancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell. [Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.]. 2011 Dec 13;20(6):701-14.
24. Pecheur I, Peyruchaud O, Serre CM, Guglielmi J, Voland C, Bourre F, et al. Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone. Faseb J. 2002 Aug;16(10):1266-8.
25. Wobus M, Rangwala R, Sheyn I, Hennigan R, Coila B, Lower EE, et al. CD44 associates with EGFR and erbB2 in metastasizing mammary carcinoma cells. Appl Immunohistochem Mol Morphol. [Research Support, Non-U.S. Gov't]. 2002 Mar;10(1):34-9.
26. Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell. [Research Support, N.I.H., Extramural

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