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Regulation of Food Intake in Obese People: Little Evidence for an Antiobesity Drug

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Regulation of Food Intake in Obese People


WHAT IS OBESITY?

The most common eating disorder in our society is excessive eating which includes craving and compulsive eating which can quite often result in obesity (http://www.nutramed.com/zeno/addictive.htm#exorphins). Obesity is a body condition where a person's body mass index is greater than 30. Other diseases that can accompany or follow obesity include diabetes, hypertension, and heart disease. Also, obese people are at a greater risk of certain kinds of cancer like breast, colon, and uterine cancer. Nori Geary, an associate professor of psychiatry at Cornell University, did a great deal of work on the physiological control of feeding behavior (http://www.med.cornell.edu/rasp/gdir/geary.html).

Some people respond well to proper diet and exercise to overcome obesity. For those who do not, however, antiobesity drugs are gaining popularity in pharmaceutical compnaies. One potential antiobesity drug that was recently developed by scientists in France and England is butabindide. This drug works to regulate appetite by breaking down a neurotransmitter that signals satiety. This drug has not yet been administered to humans, but its development may provide information to help with the development of other antiobesity drugs in the future (Jack 1756).

FEEDBACK MECHANISMS AND FAT INTAKE

A number of biological and psychological factors are involved to consolidate energy intake, expenditure, and storage to satisfy specific biological or biophysiological processes. The degree to which these processes control eating behavior is regulated by sensors in the gastrointestinal tract, the liver, and the brain which all work to control this system through a process of positive an...


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... appear to look convincing if it were not for the experiments showing that certain CCK antagonists have not shown a convincing effect on the eating patterns in humans. Other hormones including bombesin, gastric inhibitory polypeptide, glycogen-like insulino-tropic peptide, and pancreatic glucagon may also alter satiety, but the data showing that these hormones really have an effect is not persuasive enough (Read 8).

Works Cited

Aceto, Chris. (1996) Fat Burners. Joe Weider's Muscle and Fitness. 57: 90-100.

Jack, David. (1996) Fighting Obesity the Franco-British Way. The Lancet. 347: 1756-1758.

Read, Prof. (1994) The Role of the Gut in Regulating Food Intake in Man. Nutrition Reviews. 52: 1-9.

Rolls, B., Dimeo, K., amd Shide, D. (1995) Age-Related Impairments in the Regulation of Food Intake. The American Journal of Clinical Nutrition. 62: 923-935.


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