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research on antibiotic resistance
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the challenge of antibiotic resistance
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The Evolution of Antibiotic Resistant Bacteria
Since antibiotics, such as penicillin, became widely available in the 1940s, they have been called miracle drugs. They have been able to eliminate bacteria without significantly harming the other cells of the host. Now with each passing year, bacteria that are immune to antibiotics have become more and more common. This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1).
Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die. On the other hand, cells that have some resistance from the start or acquire it later may survive. At the same time, when antibiotics attack disease-causing bacteria, they also attack benign bacteria. This process eliminates drug-susceptible bacteria and favors bacteria that are resistant. Two things happen, populations of non-resistant and harmless bacteria are diminished, and because of the reduction of competition from these harmless and/or susceptible bacteria, resistant forms of disease-causing bacteria proliferate. As the resistant forms of the bacteria proliferate, there is more opportunity for genetic or chromosomal mutation (spontaneous DNA mutation (1)) or transformation, that comes about either through a form of microbial sex (1) or through the transference of plasmids, small circles of DNA (1), which allow bacteria to interchange genes with ease. Sometimes genes can also be t...
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... perspective must go beyond curing bacterial disease right now (3). This understanding must extend to the need to preserve microbial communities that are susceptible to antibiotics, so they will always be able to out-compete resistant strains.
Bibliography:
References
1) Lewis, Ricki, “The Rise of Antibiotic-Resistant Infections”. Food and Drug Administration Publication. http://ww.fda.gov/fdac/features/795_antibio.html September, 1995.
2) Levy, S., Bittner, M., and Salyers, A. “Ask the Experts”. Scientific American: http://www.sciam.com/askexpert/medicine/medice15.html.
3) Levy, Stuart B. “The Challenge of Antibiotic Resistance”. Scientific American: http://www.sciam.com/1998/0398issue/0398levy.html.
4) Zajicek, Gershom. “The Antibiotic Paradox: How Miracle Drugs Are Destroying the Miracle”. Plenum Press, N.Y. 1992.
Head scientist of the antibiotic research center at McMaster University in Hamilton, Ohio, Gerry Wright, has studied the genes of 500 streptomyces strains, a type of bacteria, many of which had never previously been identified. All 500 strains held antibiotic-resistance genes and on average were resistant to 8 of 21 tested antibiotics (Sachs). With an average resistance rate as high as 67 percent in some of these streptomyces species, it is evident that antibiotic-resistance is a rising problem. Regardless of the countless studies proving antibiotic-resistance and articles about the subject, it is one the public knows little about. With such a history of antibiotic benefits, it is difficult to perceive the negative affects these drugs have. This is the main reason antibiotic studies are disregarded. If the large majority of the population continues to do little to avert antibiotic-resistance, bacteria will evolve beyond medical treatment. Actions must be taken by the community as a whole, and even further by the individual, to “reduce the spread of microbes and improve our defense against them” (Schmidt 272). Although antibiotic resistance is inevitable, humans are accelerating the natural defense of microbes through the overuse and misuse of antibiotics.
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
Yang, J. (2009, August 21). Experts concerned about dangers of antibacterial products. The Globe and
Long before humans discovered antibiotics, they existed in nature. So naturally, after penicillin was introduced, some germs were already naturally resistant to the drug. As we used more and more of the antibiotics, we incidentally caused drug-resistant germs to progress. So, even if you’ve never misused antibiotics, you could still become infected by bacterium most drugs won’t kill. For each drug, there are germs genetically programmed to survive- some w/ outer walls tough for antibiotic to cross, others with ways to dump the drugs back out before they can work, and yet others can inactivate the antibiotic. Even worse, by passing tiny packets of genetic material to other bacteria, these survivor germs sometimes also pass the formula for resistance to the other bacteria. The best way you can protect yourself and your family against drug-resistant bacteria is by using antibiotics correctly. Taking them when they’re not needed encourages the takeover of drug-resistant strains in your body. (Redbook, pg.95) That’s because when antibiotics are given, the normal bacteria in your body are killed off, leaving lots of bacterial “parking spaces'; open. And the germ left to fill them is the drug-resistant ones. (Redbook, pg.95) So far, antibiotic resistance has not been a big problem with streptococcus A, the germ familiar to all of us for causing millions of cases of strep thr...
Bacteria are living organisms, and as such they have the ability to evolve by mutation and natural selection. This is the process by which random genetic mutations create individuals better suited to their environment, which then live to reproduce. The progeny of this individual will then have this mutation, and so a species evolves. One of the largest problems facing the medical profession today is that harmful, that ...
In 1928, Alexander Fleming, a Scottish biologist, pharmacologist, and botanist, discovered the first natural antibiotic: Penicillin. All of you reading this have at some point in time made use of his discovery. Penicillin antibiotics were among the first drugs to be effective against many previously serious diseases, such as syphilis and infections caused by staphylococci and streptococci. Antibiotics in general remain one of the cornerstones of modern health care, acting as something we all hope to rely on when we get sick. We could very easily name the 20th century “the age of the antibiotic,” and it would be well deserved, indeed. But time is running out.
Bacteria that is resistant to antibiotics is a major problem not only for the United States, but worldwide. According to the Centers for Disease Control and Prevention (2012) the cause is related to “widespread overuse, as well as inappropriate use, of antibiotics that is fueling antibiotic resistance”. According to World Health Organization (2013) resistance is a global concern for several reasons; it impedes the control of infectious diseases, increases healthcare costs, and the death rate for patients with resistant bacterial infections is twice of those with non-resistant bacterial infections.
The exacerbating effects and devastation caused by bacteria such as Mycobacterium,Vibrio cholerae, Bacillus anthracis, Xylophilus ampelinus, etc, is the growing threat of drug-resistance in many parts of the world. Identifying and addressing barriers to effective and timely diagnosis and treatment of drug-resistant diseases will be critical to preventing further emergence of strains of the disease with broad-spectrum resistance.
Antibiotics are used worldwide and although their uses have helped many people, it doesn't come without risk. The use of antibiotics treats people and animals alike to cure infection and are easily excusable through physicians. However in recent years, since antibiotics are used so universally, antibiotic- resistant strains have become a growing problem. This suggest that the bacteria is adapting to the antibiotics and through natural selection, the antibiotic- resistant bacteria have grown in numbers. The scientific community worries about future treatment of diseases if the bacteria continues to adapt. For example tuberculosis which hasn't been a problem in some time, has started to reoccur as a much harder to treat strain. Antibiotics are the go to method of treating infection but we need to be careful when we are using them.
Antibiotic resistance evolves naturally through natural selection via random mutation, but it could also be engineered by applying an evolutionary stress on a population. The antibiotic action is an environmental pressure; those bacteria which have a mutation allowing them to survive will live on to reproduce. They will then pass this trait to their offspring, which will be a fully resistant generation. Studies at the Finnish Academy found that using one type of antibiotic increases the resistance of bacteria to other types of antibiotics as well. Antibiotics do not work against illnesses t...
Antibiotics have been vital tools in the fight against bacterial infections, however their effectiveness has waned in recent times due to the advent of antibiotic resistant strains of bacteria. According to a review by P, the uses of antibiotics, as well as influences from the environment have allowed such bacterial strains to respond to changes in their environment rapidly, and so develop resistance. This acquired ability can have serious and broad implications in the medical field, evident in a study by O into the resistance of intestinal Staphylococcus aureus.
Misuse or overuse of antibiotics plays a key role as to why bacteria have become resistant to antibiotics. With antibiotics easily available these days people will s...
Antibiotic resistance occurs in bacteria when the use of antibiotics manages to kill off every bacteria except for a lone few. The lone few then live to pass on their DNA every time they undergo binary fission and the antibiotic resistance bacteria spread. This antibiotic resistance has given rise to numerous problems in the medical world as the bacteria they used to handle with a prescription of antibiotics now thrive without barriers. Currently, the main six bacteria that present problems with antibiotic resistance are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp., collectively known as the ESKAPE pathogens. Collectively these ESKAPE pathogens claim
There are many medical professionals who believe that the rise of antibiotic resistance is a result of the overuse and misuse of antibiotics. Dr. Jim Wilde, a paediatric emergency medicine physician at the Medical College of Georgia believes that the medical profession is losing the war against resistance...
Thesis: With the advent of antibiotics in 1929 Fleming said, "The time may come when penicillin can be bought by anyone in the shops.Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant."With the overuse of antibiotics today we have seen this very idea come to be.Over usage is caused most prevalently by a lack of education on the part of the patient.Thus stated, the way to overcome such a circumstance is to educate, not only the patient but also the physician.