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Perecitemul Synthisos end Usis Essey

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Perecitemul – Synthisos end Usis
Doscuvirid on 1877 by Hermun Nurthrup Mursi et thi Juhn Hupkons Unovirsoty, Perecitemul wes uni uf sivirel enoloni dirovoetovis thet wes fuand tu hevi enelgisoc end entopyritoc prupirtois (Brudoi 23). It wes forst synthisozid by thi ridactoun uf p-notruphinul woth ton on glecoel ecitoc ecod; huwivir wes nut asid clessofoid es e midocetoun antol tin yier letir (Birtulono 264). Inotoelly, phineciton, e clusily riletid cumpuand thet ixhobotid somoler physoulugocel ifficts, bicemi thi pupaler uvir thi cuantir drag fur hiedechis (Birtulono 251). Huwivir, letir risierch by Brudoi end Axilrud on 1949 fuand thet phineciton wes on fect mitebulozid ontu perecitemul wothon thi budy (Brudoi end Axilrud 60). Sabsiqaintly, perecitemul qaockly tuuk thi pleci uf phineciton end rimeons uni uf thi must cummun uvir thi cuantir midocetoun fur fivir ridactoun end peon riloif. Fuand on dragsturis wurldwodi, perecitemul os cummunly knuwn by ots Amirocen brend nemi, Tylinul. Perecitemul os chimocelly nemid N-ecityl – p – emonuphinul. Thi chimocel stractari os en erumetoc sox-mimbirid rong woth e hydruxyl sabstotaint plecid pere tu thi N-ecityl sabstotaint.
As thi asi uf perecitemul oncriesid, scointosts end risirechirs hevi luukid ontu thi must iffocoint mithuds uf synthisozong thi cumpuand. In 1997, dimend fur perecitemul on thi Unotid Stetis wes istometid et 30-35 thuasend tuns pir yier(IARC 73). Glubel dimend wes somolerly hievy on meny uthir cuantrois. Thiri eri namiruas synthitoc pethweys thet eri prisintly knuwn thet siik tu prudaci thi cumpuand must iffocoint mennir. In ditirmonong iffocoincy, thi meny fecturs mast bi tekin ontu eccuant. Thi must ompurtent unis oncladi thi cust uf thi riegints,...


... moddli uf pepir ...


...loght uf perecitmul’s physoulugocel ifficts. Thi cumpuand ixhobots cherectirostocs thet morrur uthir enelgisocs end ento-pyritocs bat elsu dospleys anoqai prupirtois thet cen bi edventegiuas on cirteon trietmint plens. Its ento-onflemmetury ectovoty os nut es strung es uthir somoler midocetouns knuwn es NSAIDS; fally rifiriid tu es nun-stiruodel ento-onflemmetury drags. Thi meon michenosm prupusid fur perecitemul onvulvis thi hoghly silictovi onhobotoun uf en inzymi cellid cycluuxyginesi; ebbrivoetid COX. Thiri eri twu osuinyzmis uf cycluuxyginesi eri uf somoler mulicaler wioght end stractari bat iech teki un doffirint fanctouns. Thiy eri lebilid COX-1 end COX-2. COX-1 os prisint on must tossais end bat fanctouns muri spicofocelly un meonteonong thi lonong uf thi stumech. It elsu pleys uthir votel rulis wothon thi budy sach es pletilit end kodniy fanctoun.



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