Through many studies and experiments it has been found that glucose is an important factor in muscle contraction and the metabolism of glucose is essential for life.(3) For glucose to be taken up by muscle cells it must be transported through the GLUT 4 transporter, a integral membrane protein which translocates from inside the cell to the plasma membrane in response to muscle contraction and high blood glucose levels.(textbook)
When muscle cells are subject to long periods of intense physical activity their need for glucose as a form of energy increases drastically. Using experiments that focus on glucose concentration and blood flow from the blood stream into muscle cells it was found that blood glucose accounted for 40% of oxidative metabolism when the glycogen stored glucose in muscle cells was low. GLUT4 is essential for glucose uptake and can be broken down into three steps; glucose delivery, glucose transport and glucose metabolism.
Glucose is delivered to the cells via the blood stream; an increase in blood flow, from physical activity perhaps, increases the amount ...
The ATP is used for many cell functions including transport work moving substances across cell membranes. It is also used for mechanical work, supplying the energy needed for muscle contraction. It supplies energy not only to heart muscle (for blood circulation) and skeletal muscle (such as for gross body movement), but also to the chromosomes and flagella to enable them to carry out their many functions. A major role of ATP is in chemical work, supplying the needed energy to synthesize the multi-thousands of types of macromolecules that the cell needs to exist. ATP is also used as an on-off switch both to control chemical reactions and to send messages.
The respiratory system is responsible in regulating gas exchange between the body and the external environment. Differences in respiration rate indirectly influence basal metabolic rate (BMR) by providing the necessary components for adenosine triphosphate (ATP) formation (Williams et al., 2011). Observation of gas exchange were measured and recorded for two mice (mus musculus) weighing 25 g and 27 g under the conditions of room temperature, cold temperature (8°C), and room temperature after fasting using a volumeter. The rates of oxygen consumption and carbon dioxide production were measured and used to calculate BMR, respiratory quotient (RQ) and oxidation rate. The mouse at room temperature was calculated to have a BMR of 2361.6 mm3/g/hr. Under conditions of cold temperature and fasting, the BMR values decreased to 2246.4 mm3/g/hr and 2053.2 mm3/g/hr respectively. Rates of glucose oxidation increased under these treatments while rates of fat oxidation decreased. Respiratory quotient (RQ) values were calculated to determine the fuel source for metabolic activity. On a relative scale, protein or fat appeared to be the primary fuel source for all three treatments although the mouse at 8°C had the highest RQ and may have relatively used the most glucose. It was also concluded that BMR in mice are greater than in humans.
Every day we use our skeletal muscle to do simple task and without skeletal muscles, we will not be able to do anything. Szent-Gyorgyi (2011) muscle tissue contraction in rabbit’s muscles and discovered that ATP is a source for muscle contraction and not ADP. He proposed a mechanism to cellular respiration and was later used by Sir Hans Krebs to investigate the steps to glucose catabolism to make ATP. In this paper, I will be discussing the structure of muscle fibers and skeletal muscles, muscle contraction, biomechanics, and how glucose and fat are metabolized in the skeletal muscles.
This is monitored by the cells within the Islets of Langerhans, which is located in the control (the pancreas). After skipping a meal or tough physical exercise blood glucose concentration decreases. Alpha cells in the islets detect this drop and are stimulated to secrete glucagon. Glucagon is a polypeptide hormone which influences an increase in blood glucose concentration. Glucagon travels through the bloodstream until it reaches glucagon receptors which are predominantly found in the liver, as well as, the kidneys. Glucagon stimulates the breakdown of stored glycogen to be released into the bloodstream as glucose. It also stimulates the conversion of amino acids into glucose and the breakdown of fat into fatty acids. These effectors cause an increase in blood glucose levels back towards the normal. This increase in blood glucose concentration is detected by the alpha cells which then stop the secretion of
Our body obtains the energy by digesting the carbohydrates into glucose. Volumes of glucose are required by the body to create ATP. ATP is short for 'Adenosine Triphosphate ' and is an energy carrier. When we consume too many carbohydrates our body produces a lot of glucose and as a result blood glucose levels rise and sometimes they may rise over the normal range of blood glucose concentration. To bring it back within the healthy range, the homeostatic system of blood glucose regulation is used. The blood flows through the pancreas where the beta cells, receptors, detect the high blood glucose level. To counteract this stimuli beta cells alert the control centre, which are also the beta cells located in the islets of Langerhans in the pancreas. The secretion of insulin has to be done quickly but can only be carried out when insulin gene is switched on. Turning on the insulin gene switch can take 30 minutes to an hour therefore, the production of insulin by beta cells are done in advance and are packaged in vesicles right until blood glucose rises. Glucose comes into the beta cell to trigger the vesicle that contains the insulin to move towards the plasma membrane and fuse. This releases the insulin into the bloodstream where they are distributed throughout the body and only affect specific target cells. The receptor, a protein, on the target cell’s plasma membrane recognises and connects
In order to test this theory the researchers injected the GluRs into the blood stream of a normal
On a cellular level, Mrs. Jones’ cells are dehydrated due to osmotic pressure changes related to her high blood glucose. Cells dehydrate when poor cellular diffusion of glucose causes increased concentrations of glucose outside of the cell and lesser concentrations inside of the cell. Diffusion refers to the movement of particles from one gradient to another. In simple diffusion there is a stabilization of unequal of particles on either side of a permeable membrane through which the particles move freely to equalize the particles on both sides. The more complex facilitated diffusion is a passive transport of large particles from a high concentration of particles to a lower concentration of particles with the aid of a transport protein (Porth, 2011). The cellular membranes in our bodies are semipermeable allowing for smaller molecules to flow freely from the intracellular to extracellular space. The glucose molecule, however; is too large to diffuse through the cellul...
The extra heat produced during metabolic exchange, raises the body temperature again affecting the enzymes and heat is then removed by sweating. If the body isn’t kept hydrated during exercise, dehydration will occur, causing the blood to become concentrated. When the blood becomes concentrated, the cells no longer have enough water to function.
...s a component monomer of starch. As a monomer as opposed to a polymer, it is much smaller and would thus be able to cross the plasma membrane. However, glucose is a larger solute than the component ions of salt, thus meaning that simple diffusion would not be sufficient. Instead, facilitated diffusion would be needed to transport the glucose. However, in the dialysis tubing, there is no facilitated transport like there is for the plasma membrane. Thus, the glucose may pass through the dialysis tubing, but it would not be due to transport, but the artificial enlargement of the passages in the dialysis tubing. Water would move freely inside and outside of the cell, however, because there is a greater solute concentration inside the cell, the water would diffuse through osmosis into the cell model, increasing the final mass of the dialysis tubing and causing cytolysis.
Tremblay, A., Simoneau, J., & Bouchard, C. (1994). Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism, 43(7), 814--818.
Our body needs energy to carry out its functions properly. This energy is synthesized from the food we eat. Our body breaks down the food we take in and then build up the required materials for a healthy functioning of our body. Glucose, a simple sugar or monosaccharide that is the end product of carbohydrate digestion, is a primary source of energy for living things. (Taber’s, 2005). Glucose gets absorbed from our intestines and distributed by the bloodstream to all of the cells in our body. If the supply of glucose is more than required, our body stores the excess amount of glucose as glycogen, a chain of glucose. If there is shortage in other hand, our body uses the stored...
A. One condition is known as hyperglycemia, which means that the blood glucose gets too
When the blood glucose is higher than the normal levels, this is known as diabetes disease. The body turns the food we eat into glucose or sugar and use it for energy. The insulin is a hormone created by the pancreas to help the glucose get into the cells. The sugar builds up in the blood because either the body doesn’t make enough insulin or can’t well use its own insulin (CDC, 2015). In the United States diabetes is known as the seventh leading cause of death. There are different types of diabetes. However, there are two main types of diabetes and these are; Diabetes type 1 and Diabetes type 2 (CDC, 2015).
Blood glucose (sugar) levels go up and down throughout the day depending on a numbe...
...hunger as the hormone insulin lets cells to enter glucose in the blood; when the pancreas discharges insulin hunger will rise.