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Cause and effect of heart disease
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Heart diseases are a leading cause of death throughout the world. Myocardial infarction with serious damage to the left ventricular function as well as valvular heart disease continue to affect many people causing morbidity and mortality (Weber et al. 2013). Valvuar heart disease includes a condition called valvular stenosis, where the tissues in the valves become stiffer and fails to open properly, resulting in the valve opening to become narrow. This causes the blood flow to lessen due to not being able to flow thoroughly, which may cause the body to not receive proper blood flow. Myocardial infarction is the death of the cells in an area of the myocardium. This causes oxygen deficiency that is caused by a block in the blood supply also known as a heart attack. The left ventricle is the common site for MI, which is the chamber of the heart that works the most. This results in fibrotic scar formation and permanently impaired cardiac function (Zammaretti 2004). Tissue changes in the myocardium are associated to how much the cells have been deprived of oxygen. Thi...
The aim of this report is to provide an overview of chronic heart failure, examining signs symptoms and treatment related to the case study, and the anatomy and physiology of the heart will be discussed, and the pathophysiology of chronic heart failure. The size of the heart is approximately the size of a persons closed fist. The weight is less than a pound, the heart is snugly enclosed within the Infer mediastinum, and the medial section of the thoracic cavity, the heart is flanked on each side by the lungs (Marieb, 2014). Pericardium surrounds the heart, the fibrous pericardium the superficial part of the pericardium aids in protection of the heart from moving freely around the thoracic cavity.
Coronary heart disease is defined by the hardening of the epicardial coronary arteries. The buildup of plaque in the arteries slowly narrows the coronary artery lumen. In order to better understand the physiology of the disease, it is important to first know the basic anatomy of the human heart. The aorta, located in the superior region of the heart, branches off into two main coronary blood vessels, otherwise known as arteries. The arteries are located on the left and right side of the heart and span its surface. They subsequently branch off into smaller arteries which supply oxygen-rich blood to the entire heart (Texas Heart Institute, 2013). Therefore, the narrowing of these arteries due to plaque buildup significantly impairs blood flow throughout the heart.
The term, ischemia, denotes inadequate blood supply to tissues due to blockage of the arterial inflow, while, reperfusion injury is defined as the injury caused by the restitution of blood flow after an ischemic peroid, leading to death of cells that were only reversibly injured at the time of blood flow restitution. [63]. The final infarct size after an MI event is therefore the result of the ischemic and reperfusion damage. For this reason, the term that best describes this process of myocyte death in reperfused MI is myocardial ischemia/reperfusion (I/R) injury [64]. In the early hours post myocardial ischemia, injured cardiac cells can release several molecules, including adenosine, opioids, and bradykinin, which activate the G protein signaling pathways therefore promoting myocardial survival. While in the late phase, myocardial ischemia induces upregulation of growth factors and cytokines, including VEGF, ILGF and SDF-1, in the injured myocardium, hence promoting a cardio-protective state. The liver also participates in cardioprotection through the up regulation and release of secretory proteins, including FGF21 and TFF3, which also promote cardiomyocyte survival. [65]. Foundational studies performed about three decades ago with animal models demonstrated that an early reperfusion was able to limit infarct size [66]. Then fibrinolysis was indisputably associated with a decrease in mortality in patients with STEMI [67].A decade later; primary angioplasty was shown to be more superior than fibrinolysis [68]. Currently primary coronary angioplasty (PCI) has been established as the backbone treatment for STEMI patients. The period from the onset of symptoms of MI (representative of the time of coronary occlusion) and reperfusio...
What is a Myocardial Infarction? Myocardial Infarction, also known as a heart attack, occurs when there is a blockage in one of the coronary arteries. The heart is a muscle that needs oxygenated blood and nutrients to survive. When a blockage occurs in the arteries, oxygen and nutrients are cut off from the heart for an extensive time. The blocked portion of tissue in heart dies. Blockages can occur due to several factors. Coronary artery disease is the most prevalent cause. Coronary artery disease or atherosclerosis is due to plaque buildup and narrowing in the artery walls. These plaques are made from cholesterol and waste products. This buildup on artery walls can restrict blood flow; a process that can take
Since 1960 the age-adjusted mortality rates for cardiovascular disease (CVD) has declined steadily in the U.S. due to multiple factors, but still remains one of the primary causes of morbidity and premature mortality worldwide. Greater control of risk factors and improved treatments for cardiovascular disease has significantly contributed to this decline (Centers for Disease Control and Prevention, 2011). In the U.S. alone it claims approximately 830,000 each year and accounts for 1/6 of all deaths under the age of 65 (Weiss and Lonnquist, 2011). Based on the 2007 mortality rate data an average of 1 death every 37 seconds is due to cardiovascular disease (Lloyd-Jones et al., 2009). Controlling and reducing risk factors is crucial for saving lives. There are a number of contributing risk factors for cardiovascular disease, which may appear in the form of hereditary, behavioral, and psychological, all of which ultimately converge in social or cultural factors.
“Heart failure is a chronic, progressive condition in which the heart muscle is unable to pump enough blood through to meet the body's needs for blood and oxygen” (American Heart Association, 2012, para 3). What this basically means is that the body is functioning in a way that the heart cannot keep up with. Although heart failure can be acute and occur suddenly, it usually develops over time and is a long-term or chronic condition. There are two different types of heart failure, left-sided and right-sided, and they can be caused by other diseases such as diabetes, coronary heart disease, or high blood pressure (National Institutes of Health, 2012). In most cases, both sides of the heart are affected simultaneously.
Succinctly speaking, a myocardial infarction is not a disease but rather an event occurring due to the progression of coronary heart disease. 1(p.125) With coronary heart disease, the flow of blood which supplies the heart with oxygen is blocked, reducing the amount of oxygen received by the cardiac muscles and resulting in damage or death of cardiac muscle....
Heart Disease You need your heart for all your body needs. It pumps about 2000 gallons of blood a day. It takes about 20 seconds for blood to reach every cell in the body. An artery that carries blood out of the heart.
The heart serves as a powerful function in the human body through two main jobs. It pumps oxygen-rich blood throughout the body and “blood vessels called coronary arteries that carry oxygenated blood straight into the heart muscle” (Katzenstein and Pinã, 2). There are four chambers and valves inside the heart that “help regulate the flow of blood as it travels through the heart’s chambers and out to the lungs and body” (Katzenstein Pinã, 2). Within the heart there is the upper chamber known as the atrium (atria) and the lower chamber known as the ventricles. “The atrium receive blood from the lu...
Heart disease is the leading cause of death for both women and men in the United States. It is very important to learn about the heart to prevent heart disease. Many forms of heart disease can be prevented and treat with healthy lifestyle choices. For someone who has heart disease or does not; there is information, facts, symptoms, different types, diagnoses, tests, treatment, care, and living and managing that can be given.
Coronary Heart Disease Coronary heart disease is the most common form of heart disease. It is a general term for both heart attack and angina. Many people suffer from it and 500,000 Americans die from it each year. It is much more common in older people and in males. However, women tend to be older and sicker when they are first treated for a heart attack.
Causes of Heart Disease Heart disease or coronary heart disease (CHD) is mainly caused by Atherosclerosis. This occurs when the inner lining of your artery walls becomes furred with a thick, atheroma which is made up of fatty deposits of cholesterol, cell waste and other substances. These form raised patches on the artery wall known as 'plaques' which narrow the arteries reducing the space through which blood can flow. At the same time the blood becomes more prone to clotting. The growing plaques may block the delivery of nutrients to the artery walls, causing them to lose their elasticity.
Most often the disease starts in the left ventricle, and then often spreads to both the atrium and right ventricle as well. Usually there will also be mitral and tricuspid regurgitation, due to the dilation of the annuli. This regurgitation will continue to make problems worse by adding excessive volume and pressure to the atria, which is what then causes them to dilate. Once the atria become dilated it often leads to atrial fibrillation. As the volume load increases the ventricles become more dilated and over time the myocytes become weakened and cannot contract as they should. As you might have guessed with the progressive myocyte degeneration, there is a reduction in cardiac output which then may present as signs of heart failure (Lily).
These causes will change the heart significantly. The pathophysiology of heart failure is described differently as: (1) an oedematous disorder, by means of which the deviations in renal hemodynamics and excretory ability lead to salt and water holding; (2) a hemodynamic disorder, considered by peripheral vasoconstriction and decreased cardiac output; (3) a neurohormonal disorder, mainly by stimulation of the renin-angiotensin-aldosterone system and adrenergic nervous system; (4) an inflammatory syndrome, related with amplified local and circulation pro-inflammatory cytokines; (5) a myocardial disease, started with an damage to the heart trailed by pathological ventricular transformation. In heart failure, the heart sustains either a sudden or longstanding structural injury. When damage occurs, sequences of firstly compensatory but consequently maladaptive mechanisms follow (Henry & Abraham, ).
Etiology Myocardial infarction occurs when the coronary arteries are blocked by a blood clot. It is commonly known as a “heart attack”. The heart needs its own constant supply of oxygen and nutrients to work properly. Two coronary arteries deliver oxygenated blood to the heart, and if one of these two arteries fails or becomes blocked, then a portion of the heart will not acquire the necessary oxygen. This clot could be because of CAD (coronary artery disease), which happens when the inner walls of the coronary arteries thicken because of buildup of cholesterol, fatty deposits, calcium among other elements that are carried in the blood (Boston Scientific, 2009).