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Chapter 9: The Immune System and Mechanisms of Defense
Summary of immunology
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The Immune System The immune system are processes and structures within an organism to help protect it from foreign attackers. The immune system consists of cells, tissues, and organs; such as lymphocytes, lymph nodes, phagocytes, and many others. In order for the immune system to function properly it must first learn to discriminate between self-cells and foreign cells. Cells marked “self” need to be left alone. Cells that are foreign should be identified as “non-self” and cause the immune system to start to defend the body. Any foreign microbe or antigen, an antigen is any substance that causes an immune response, will activate the immune system. To prevent an auto immune disease, a disease where the body attacks its own cells, cells must first undergo central tolerance; the immune system’s ability to recognize self-cells and not attack them. There are two types: first, central tolerance, and second, peripheral tolerance. Central tolerance is acquired when the cell is first developing in bone marrow; the immature immune cell must learn to not attack its own bodily cells. If the ...
The immune system is made up of a network of cells, tissues, and organs that work together to protect the body, and it defends the body from “foreign invaders.” Immunity can be divided in two three different defenses, and these are defined as first, second and third lines of defense. The first line of defense for the immune system is the primary defense against pathogens entering the body from the surface in order to prevent the start of disease and infection. Some examples of the first line of defense is the skin, protecting the external boundaries of the body, and the mucous membranes, protecting the internal boundaries of the body. Although the skin and mucous membranes work on the internal and external boundaries, they both release chemicals
When functioning properly, the immune system identifies a variety of threats, including viruses, bacteria and parasites, and distinguishes them from the body’s own healthy tissue. The major components of the immune system include: lymph nodes, bone marrow, spleen, lymphocytes, thymus, and leukocytes. Lymph nodes are small bean shaped structures that produce and store cells that fight infection and disease and are part of the lymphatic system. The lymphatic system and the immune system are very closely related. Lymph nodes also contain a clear fluid that carries cells to different parts of the body. When the body is fighting off infection lymph nodes can become enlarged and swollen and even feel sore. For example, when the body is trying to fight off an infection you may notice that the lymph nodes around your neck which are located under your ears become
The lymphatic system are a complex network of specialised cells and organs that defend the body against infection. Lymphatic organs include the bone marrow, spleen, thymus gland, lymph nodes, tonsils, adenoids, appendix and clumps of tissue in the small bowel. A function of the lymphatic system is to nurture and mature the B and T-lymphocytes (white blood cells vital to immune function). Cancerous changes can take place when mutation leads to failure of the cells maturing of the lymphoid cells.
The immune system is the body's third line of defense. It is a network of several tissues and white blood cells. The tissues of the immune system are bone marrow, thymus, lymph nodes, spleen, tonsils, and adenoids. The white blood cells of the immune system are called lymphocytes (Postlethwait Hopson, Modern Biology).
Differentiate and describe between monocytes and macrophages (Innate Immunity) and B cells defining antibodies and T cells defining cytokines (adaptive immunity).
The function of the immune system is it helps play a vital part of our everyday lives. It helps protect our bodies where ever we go. Our immune systems help defend our bodies against germs and microorganisms. The immune system is made up of various special cells, tissues, organs and proteins. This special system does an amazing job of keeping our bodies healthy and in good shape from different diseases and infections.
Acquired immunity is the immunity that our body gains and develops over time. When pathogens are present in the body our body learns and remembers how to destroy these pathogens. Acquired immunity compromises all our specific immune responses which includes the generation of antibodies that neutralize the toxins produced by the pathogen. Acquired immunity means our body is able to distinguish between different types of pathogens, differentiate between foreign particles and cells of our own body and recall all immunological responses and act accordingly to the specific pathogen. The third line of defense is involved which is acquired and specific.
Seattle Education Project. (2013, November). STEP: The Immune System - An Overview, [Online]. Available: http://www.thebody.com/step/immune.html [11/12/14].
Willey, 2014). The adaptive immunity contains Naïve B cells which turn into antibodies, and naïve T cell which later turn into effector T cells (Joanne M. Willey, 2014). Adaptive immunity has memory (Joanne M. Willey, 2014). This means that the adaptive immunity is a prompt and stronger immune reaction to the same microbe later on if it comes back (Joanne M. Willey, 2014). As a part of this third line of defense, it involves antibodies, along with lymphocytes called T cells and B cells (Joanne M. Willey, 2014). They change to handle a particular microbe (Joanne M. Willey, 2014). Foreign substances that start up an immune response are called antigens (Joanne M. Willey, 2014). The presence of external antigens causes B and T cells to replicate and make more proteins that function to protect the host (Joanne M. Willey, 2014). The B cell is most important because it produces and secretes antibodies. Antibodies bind to antigens and inactivate them to help kill them (Joanne M. Willey,
Our body consists of 90% of bacteria. That means that for every cell that we have in our body, we have 9 bacterial cells living along with it. Granted that most of the bacteria live inside the intestinal tract, but without a proper immune system keeping the digestive system in check, we would not be properly digesting food or have healthy bodies.
The immune system is a highly evolved and complex defence system, armed against millions of potential pathogens that may cause infection at any point. Pattern recognition receptors, known as PRRs, are displayed by the cells of the innate immune system, such as macrophages and dendritic cells, and recognise pathogen associated molecular patterns or PAMPs. PAMPs are evolutionary conserved structural similarities found in many pathogens but not in the host’s own cells allowing the innate immune system to distinguish between self and non self and to react to the pathogens immediately (Mogensen, 2009). Antigen recognition receptors are used by the lymphocytes of the adaptive immune system to provide a highly specific and targeted response to a precise epitope of an antigen. However as a single lymphocyte carries only a single type of antigen recognition receptor that recognises one type of antigen the chance of a pathogen of finding a lymphocyte with a given specificity is low. Therefore the adaptive immune response takes time to mobilise hence the innate immune system is essential to keep the infection
According to the Australian Academy of science (2012) Immunological memory allows the adaptive immune system to rapidly clear infections that it has encountered before, this can be both naturally or artificially. Following an immune response some T-cells remain and serve as “memory cells” so if the body comes in contact with the same antigen in the future the immune system can act swiftly and more efficiently to prevent the infection occurring. (Black 2008). The Australian Academy of Science (2012) states that when the body encounters a disease naturally the immune system launches a non-specific and then specific response to the foreign body, although the person may still experience the signs and symptoms of the disease. Where...
When something foreign is produced into the body, our immune system automatically goes into overdrive. “Is this something I’ve encountered before or is this a new invader?” Our body must distinguish between the two. This is known as either a primary or secondary immune response. If this is initial contact with the foreign antigen, it is known as a primary immune response. Over a period of several days, the body begins to produce an adequate amount of antibody against the invading antigen. This is a non-specific line of defense because it is the first instance of contact with the antigen. The bone marrow produces T lymphs and B lymphs that play an important role in this primary immune response. T lymphs travel to the thymus while B lymphs
The immune system is a fascinating structure it defends the body against foreign invaders like bacteria, viruses and parasites. There are two primary forms that make up the immune system they are, innate and adaptive systems. Both the innate and adaptive system plays a large role in the immune system. The innate is the primary system to defend against foreign materials and the adaptive is the secondary system that responds to specific issues.
To humans, having a healthy immune system is essential. Our immune system is important because it helps the body fight any foreign bacteria, viruses, and diseases by attacking it, which is why we must take care of it as much as possible by strengthening it. But this so called defense system can also cause problems such as attacking donated organs or blood from another individual, unless the organs or blood are carefully matched. It may also overreact to harmless invaders such as pollen grains, which can cause hayfever, and even in certain cases, the immune system may turn against the body's own cells. The immune system uses different types of white blood cells. Some of these cells which are called macrophages, are constantly patrolling the body to destroy any germs as they enter. In the case of an infection taking hold, one’s body will begin to fight back with a much powerful defense of T and B-cells. These cells give people acquired immunity in order to prevent the same germ form making them ill again. Unfortunately with today’s environmental issues people are dealing with several health problems, especially in their immune system. Air pollution, which is one of the major environmental issues, can cause several health risks. Exposure to air pollutants can have a high possibility of resulting in long term effects on people as well as shutting down the immune system. Therefore, the pollution in the air can affect the immune system by weakening it and making it much more vulnerable to foreign invaders, illnesses, harmful bacteria, and viruses.