Hippocrates on Mental Disorders: Describing Schizophrenia as Melancholia

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1.1 Introduction:
Depression is commonly understood as an individual’s feelings of sadness or a general undermining of the individuals normal functioning which has a direct effect on the individual themselves and also their family and friends. A man by the name of Hippocrates, who was described as the father of western medicine, initially described an individual’s low mood as “Melancholia”. Hippocrates described melancholia as having specific mental and also physical symptoms. In its 2400 year history, the term melancholia has changed its meaning numerous times. The term melancholia was often used as a very broad term by Greco-Roman antiquity to describe individual’s states which today may be deemed as “schizophrenic”. The term melancholia was taken from the Latin transliteration of the Greek term melancholia. In Greece the term described a mental disorder which involved continuous low mood and also feelings of fear which sometimes meant “biliousness” and in medical speech this term described “nervous” or “crazy” behaviour. The term was taken from the words melaina chole, when translated into Latin it is astra bilis and in English is black bile (Medicalnewstoday.com, 2009).
The affect, mood or emotions caused by being depressed or melancholy is well known to humans for thousands of years. It was once believed that clinical depression did not have as broad of a range of symptoms when compared to melancholia. Symptoms of melancholia include despondency, dejection, general sadness, fear, anger, obsessions and also delusions. It is believed that Abraham Lincoln had suffered from melancholia which today is known more commonly as clinical depression (Medicalnewstoday, 2009).
The number of individuals suffering from depression is not exa...

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... anxiety (Fava et al., 1997; Flint & Rifat, 1997; Davidson et al., 2002).
A recent large-scale multicentre study of potential predictive factors related to TRD took place in Europe and displayed 5 main clinical predictors in order of their strength (1) current suicidal risk (2) comorbid anxiety disorder (3) gender (4) seasonal pattern (5) non-response to first antidepressant lifetime (Oswald et al., 2005). Non-psychiatric co-morbidities have been discovered to be predictors of TRD (Iosifescu et al., 2004). It was discovered that patients suffering from increased levels of serum cholesterol do not respond as well with Fluoxetine treatment when compared to patients with normal levels of cholesterol (Sonawalla et al., 2002). Late-life depression has been linked to comorbid somatic disorders such as circulatory problems, arthritis or skin problems (Oslin et al., 2002).

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