Resveratrol
The discovery of resveratrol dates back to 1939 with the earliest publication of it by Michio Takaoka in the journal of the chemical society of japan. The compound was extracted by crystallization from a fraction of EtOH extracts of Veratrum grandiflorum.1 Resveratrol is most famously found in the skin of red and purple gapes but other sources include cranberries, blueberries and peanuts. Japanese knot weed is also a concentrated source of Resveratrol and is used as a non-synthetic route to produce resveratrol for diet supplements2.
The structure of Resveratrol is shown (left)3. it is a stilbenoid produced by plants to help them ward off pathogens. It occurs as both E and Z isomers with the E isomer converting to Z on exposure to UV radiation.
Resveratrol has been the focus of numerous studies because of its attributed medicinal properties which include protecting heart and blood flow, as an anti-inflammatory and as an insulin sensitizer. It has also received public attention as studies show that it interferes with carcinogenesis and is effective at destroying tumours ...
Montaner, B. and Perez-Tomas, R. 2001. Prodigiosin-induced apoptosis in human colon cancer cells. Life sciences, 68 (17), p. 2025-2036.
Risperdal Risperidone is an atypical antipsychotic used to alleviate the symptoms of schizophrenia. Schizophrenia is defined by its effects in altering perception, thoughts, or consciousness called hallucinations or delusions. It affects about 1% of the population, with about 2 million people affected in the United States. About 50% of those affected become severely and permanently disabled and dependent upon public assistance. Schizophrenics make up about 10% of the totally disabled population and as much as 14% of the homeless.
Sildenafil Citrate, more commonly known by the brand name Viagra, has become one of the most commonly prescribed drugs in America. Viagra is used to treat erectile dysfunction, also known as impotence. Erectile Dysfunction is best defined as the inability to maintain an erection necessary for sexual satisfaction. Sildenafil has been shown to be effective for a "broad range ED patients, including those with a history of mellitus, depression, … hypertension, diabetes, …and spinal chord injury" (Sildenafil Citrate, par. 29).
Phenolic acids are secondary plant metabolites widely distributed in foods, especially fruits and vegetables. In recent years, phenolic acids have attracted a lot of attention because they exist ubiquitously in plants and play protective roles. Phenolic acids possess interesting biological properties, (Beilin, Stocker, & Croft, 1997) that render them interesting to study. They are widespread in crops such as fruits, vegetables, herbs, grains, and seeds and derived foods such as juices, wines, and oils, (Graf, Ameho, Dolnokowski, Milbuty, Chen, & Blumberg, 2006). Phenolic compounds play a key role in thwarting the negative impacts of oxygen and nitrogen reactive species (ROS/RNS), maintaining the redox homeostasis of biological fluids and preventing conditions such as cardiovascular diseases, atherosclerosis, and other degenerative pathologies, such as cancer, diabetes, Alzheimer’s and Parkinson’s diseases, (Shahrzad & Bitsch, 1998).
7. Stevens, J., et al. Chemistry and biology of hop flavonoids. J. Am. Soc. Brew. Chem.
Aspirin is one of the most commonly used drug in the world. The generic name is acetyl salicylic acid and the drug belongs to the group of non- steroidal anti-inflammatory medicines, which works by inhibiting the production of compounds in the body that cause pain, fever, inflammation, and blood clots (Koester, 1993. Aspirin is also a member of the salicylate family of compounds as it synthetized from salicylic acid, which was discovered in oxford (UK) by Edward stone in 1793 and first synthetized in laboratory in 1897 by a German scientist, Felix Hoffmann of the Bayer company (Rinsema, 1999). The drug is also known as Acetoxybenzoic acid, Acylpyrin, Ecotrin, Acenterine, Polopiryna, Acetosal, Colfarit and is prescribed for e.g. migraine, headache, back and muscle pain, arthritis, heart attacks and strokes. Aspirin is used in both human and veterinary medicine.
The Drug enforcement Administration has targeted as a top priority the illegal use of the prescription painkiller OxyContin in the wake of what the agency says is a dramatic and dangerous increase in the drug's availability. Simply crushing the tablet can negate the controlled-release effect of the drug, enabling abusers to swallow or snort the drug for a powerful morphinelike high. The tablet can also be crushed, mixed with water and injected. In this paper I discuss the abuse of OxyContin and other prescription painkillers.
Vitamin C is an essential in the body's defenses against infection. Susceptible children will not tolerate relatively unimportant infections and this can lead to prolonged illness and in the case of behaviorally disturbed children of symptoms previously well managed. Vitamin C is an extremely safe substance which is immensely beneficial to the brain and body in a multitude of ways. Its potential for preventing and treating autism has barely been touched. Vitamin C is heavily concentrated in the brain, but its exact role in brain function has not been fully understood. A recent search turned up 400 references referring to vitamin C and the effects of the brain, but the mystery still remains.
...r is hard to cure due to its ability to metastasis and avoid apoptosis due to mutation occurs in the genes during mitosis, especially on oncogen and tumour suppressor gene. Oncogen contribute to cancer cells by encouraging cells to grow and divide excessively while tumour suppressor genes inhibit apoptosis. As all cells on Earth require oxygen, nutrients and the ability to remove waste products to survive and develop, it seems possible to develop anti-cancer drugs which will target at those blood vessels which supply nutrients to tumour cells. Even though this method is providing some promising results, there is no significant improvement in the overall survival of the organism in the long term. Nevertheless, the understanding of cellular basis of cancer cells gain from numerous researches have certainly help in developing new and effective treatment for cancer.
Herbal remedies have been used throughout the world for thousands of years and recently their use has become popularized in America. People tend to view herbal remedies as being safer then prescription drugs because they are believed not to contain chemicals or cause side effects. St. John’s Wort is an herbal remedy, which prevents the destruction of seratonin, a natural anti-depressant, is often used to treat depression. Due to the increasing interest it St John’s wort, as well as in other herbal remedies, there has been a great deal of research done recently in the effectiveness and safety of this herb in regards to depression.
Vitamins In the early 20th century the discovery of vitamins began. Today there is a chance that there are some vitamins that are still undiscovered. The definition of vitamin is: one of several substances necessary for animal nutrition, and occurring in minute quantities in natural foods; numerous types have been distinguished, and designated by the letters of the alphabet. Each and every living animal needs vitamins to grow and be healthy.
Nutraceuticals refer to extracts of foods claimed to have medicinal effect on human health. Nutraceuticals are a large and diverse class of compounds, which occur naturally in plants. Although these compounds are considered non-nutritive, many of them possess antioxidant, anti-oestrogenic, antimutagenic, anti-inflammatory and anti-carcinogenic properties that might potentially be beneficial in preventing diseases and protecting the stability of the genome. The term ‘nutraceutical’ was coined from ‘nutrition’ and ‘pharmaceutical’ in 1989 by Dr. Stephen DeFelice (source: American Nutraceutical Association). According to DeFelice, a nutraceutical is any substance that is a food or a part of food and provides medical or health benefits, including the prevention and
Vitamin C is one of the most important vitamins. Without vitamin C, human life would not be on this planet today. It does many positive things in the human body. It increases recovery time from illnesses such as colds. It helps to prevent free radical damage and collagen glycation, which cause the body to age much faster than it usually should. It also helps to prevent major diseases, like scurvy, which results from Vitamin C deficiency. Vitamin C is necessary for human life.