Genetic Disruption in Extinct Woolly Mammoths

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2. Introduction: Woolly mammoths were one of the most common herbivores in North America, Siberia, and Beringia until they died out due to excessive hunting and global warming. Small island populations of mammoths however lived until about 3,700 years ago, while those on the mainland went extinct 10,000 years ago. Due to advancements in DNA sequencing, scientists were able to compare the DNA of a mainland mammoth from 43,000 years ago, (when the species was plentiful), and a mammoth from about 4,300 years ago, that lived on the isolated Wrangel Island. Through the comparison, the scientist saw that mammoths from Wrangel Island showed many genetic mutations or changes in the DNA that caused detrimental genetic defects. This discovery should …show more content…

Common Summary: This study focuses on the evolution and of an organism’s genetics over time. In this study, Rebekah Rogers and Montgomery Slatkin from the University of California, Berkley compared the genetic sequences between two specimens of woolly mammoths, from two different environments and population sizes to test the genome evolution theory that small isolated populations of animals will cause an accumulation of detrimental genetic mutations and defects. To identify the shifts in the mammoth’s genetics, Rebekah et al. used ancient DNA sequences to identify the differences in heterozygous and hemizygous shifts in the DNA. Here the scientist were able to observe the deletions, retrogenes, premature stop codons, and point mutations that differed between the two mammoths. Through comparing SNPs, the scientist saw that the Wrangel mammoths had 318 genes with premature stop codons and that some of those stop codons affected the gene codes for the olfactory system and the structure of the odorant binding receptors that give mammals the ability to smell. Also through the comparisons, the scientists found that the Wrangel mammoth had 27,228 deletions compared to the 21,346 deletions in the mainland mammoths. The deletions in the Wrangel DNA effected 1628 bases that coded for synapse functions, urinary protein production, pheromones; and, the deletions on the FOXQI locus in the Wrangel mammoths caused the development of translucent hairs and a satin coat. These deletions had an increase of heterozygosity in the Wrangel mammoths and showed that there were defects in the mammal’s DNA repairing mechanisms. And by using genetic ontology, the results showed that the Wrangel mammoths had 1.3x as many retrogenes as the mainland mammoths. The increase of retrogenes included genes that affected transcription, translation, cell division, DNA repair, and the chaperones of protein

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