Thesis Statement For Down Syndrome

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1. Thesis Statement: infants and children with Down Syndrome can develop myeloid leukemia (Z. Haque, 2016 ). Down syndrome is a genetic disorder caused by aneuploidy of chromosome 21. Aneuploidy is the addition or removal of chromosomes. Due to further alterations of the genetic material, the child with Down Syndrome can develop myeloid leukemia. A child with Down Syndrome has an increased risk of developing myeloid leukemia vs. a normal child. The mutations of the GATA1 gene has a direct relationship of the development of the disease, due to the missing N-terminal domain (Ahmed, 2014 )

2. Down Syndrome affects the genetic material of infants and children. Down Syndrome is a disease that is not inherited and most often is observed in infants of normal parents. Down Syndrome or trisomy 21 is characterized by the gain of one chromosome. Having genetic alterations can cause further development of other diseases like leukemia.
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(S Aivazidis., 2017)
• Down syndrome is also associated with other diseases such as: leukemia, seizures, vision problems, diabetes, dementia and Alzheimer's disease. (S Aivazidis., 2017)

3. Down Syndrome and the development Myeloid leukemia has been diagnosed mostly in infants and children. Myeloid Leukemia is a type of cancer of the blood. Myeloid leukemia has a low number of leukemic blast in the bone marrow, and mutations in GATA1 gene. (D De Souza., 2017) The characteristic of down syndrome is having additional chromosomes, having a disruption of chromosomes can have further implications for irregularities that can occur in a person’s genome.
• Infants/Children with down syndrome have a higher chance of developing leukemia.
• The following types of leukemia in children and infants with down syndrome have been

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