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The advent of penicillin
Antibiotic resistance review
Antibiotic resistance affects patient care
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Recommended: The advent of penicillin
An Evolving Epidemic
Head scientist of the antibiotic research center at McMaster University in Hamilton, Ohio, Gerry Wright, has studied the genes of 500 streptomyces strains, a type of bacteria, many of which had never previously been identified. All 500 strains held antibiotic-resistance genes and on average were resistant to 8 of 21 tested antibiotics (Sachs). With an average resistance rate as high as 67 percent in some of these streptomyces species, it is evident that antibiotic-resistance is a rising problem. Regardless of the countless studies proving antibiotic-resistance and articles about the subject, it is one the public knows little about. With such a history of antibiotic benefits, it is difficult to perceive the negative affects these drugs have. This is the main reason antibiotic studies are disregarded. If the large majority of the population continues to do little to avert antibiotic-resistance, bacteria will evolve beyond medical treatment. Actions must be taken by the community as a whole, and even further by the individual, to “reduce the spread of microbes and improve our defense against them” (Schmidt 272). Although antibiotic resistance is inevitable, humans are accelerating the natural defense of microbes through the overuse and misuse of antibiotics.
The natural components of antibiotics have been used as local remedies long before humans understood the reasons why these sometimes-radical treatments worked. Penicillin became the first manufactured antibiotic after physician Alexander Fleming published articles regarding this bacteria-disabling mold in 1928. Come 1932, penicillin was commonly used to treat infected war injuries, saving the lives of unnumbered soldiers (Lewis). Since then, penicillin has b...
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...rding the importation of food products and live animals, other organisms which carry bacteria. In a world governed by international relations, travel is a large part of today’s society. The leisure and significance of world travel is unlikely to depreciate.
Therefore, local communities must take actions regarding antibiotic-resistance, whether they are awareness programs or state and nationally regulated laws. The act of hindering antibiotic-resistance development is also an individual commitment. People must understand the effects of excess antibiotics and commit to making a difference. These acts may be as simple as not demanding unnecessary antibiotics and finish the entire course when antibiotics are prescribed. Regardless to the natural evolution of bacteria, society must delay the development of antibiotic-resistance within bacteria with humanity has hastened
The Factor of War in the Development of Penicillin The discovery, development and subsequent use of penicillin can be considered to be one of the most important breakthroughs in medical history. There were many factors, which were involved in the development of penicillin, and it could be argued that war was the most important, but other factors were also responsible. Alexander Fleming was working in London as a bacteriologist in 1928 when he noticed that a growth of a mould called penicillin produced a substance that actually killed the germs he was working on. He realised that this might be very important and a year later he wrote an article about his findings. However, Fleming did not have the facilities or the support to develop and test his idea that penicillin could fight infection, and he didn't develop it further.
Years later other scientists were also intrigued by the possibilities of penicillin and produced enough penicillin to prove that it was a useable antibiotic. The scientists from Great Britain were developing all of this during World War II, and unfortunately funding for their drug was unavailable due to the war. They decided to bring their concepts to the United States, and once enough was made, it was eventually used, to treat wounded soldiers during World War I.
According to USA Today, U.S. doctors are prescribing enough antibiotics to give to 4 out of 5 Americans every year, an alarming pace that suggests they are being excruciatingly overused. In fact, Dr. Aunna Pourang from MD states, “to give you an idea of how high the pressure is to prescribe antibiotics, I didn’t get a job once because during the interview I told the lead physician that I only prescribe antibiotic prescriptions when they are warranted.” The development and widespread obsession of antibiotics, or drugs that kill bacteria and thereby reduce infection, has helped billions of people live longer, healthier lives. Unfortunately, the more we rely on and abuse antibiotics, the more bacteria develop resistance to them, which makes treating infections that much more challenging and leads to the growth of drug-resistant strains of bacteria. Research from the Center of Disease Control found that two million people in the United States become infected with antibiotic resistant bacteria, while 23,000 people die from such infections each year. Americans often aren’t informed on the power of the human body and rush to assumptions when perfection isn’t present. In a nutshell, the obsession of antibiotics is quite deadly and needs to be addressed before it’s too
Antibiotic resistance is one of the most important issues facing health care today, with wide reaching future implications if abuse continues. In the United States alone, antibiotic resistance is responsible for over two million illnesses and 23,000 deaths per year. Providers need to be judicious in the disbursement of these life saving pharmacological agents, while being informative of why antibiotics are not always the answer (Talkington, Cairns, Dolen, & Mothershed, 2014). In the case listed below, several issues need to be addressed including perception, knowledge deficit, and the caregiver’s role. This paper will focus on whether a prescription for antibiotics is appropriate and other courses of action that may be taken instead.
“The World Health Organization projects that as drug effectiveness decreases and antibiotic resistance increases, public education becomes more and more crucial” (476) Antibiotics were discovered in 1940 and since have been abused and misused. Between bad practices and lack of proper education antibiotic resistance has been allowed to occur. The only way to combat bacterial infections is with strong patient education and following the correct schedule in taking antibiotics.
Resistance arises from mutations that are not under the control of humans, but the evolution of bacteria has been sped along by the overexposure of antibiotics to both people and animals. The number of antibiotic-resistant strains of bacteria in an area is closely related to the frequency that antibiotics that are prescribed (Todar, 2012). Patients often unnecessarily demand antibiotics to treat common colds or simple illnesses that are not caused by bacteria. Instead, these infections are caused by viruses which, unlike bacteria, are unaffected by antibiotics. Incorrect diagnosis can also lead patients to using unnecessary antibiotics, which can sometimes be even more dangerous than otherwise left untreated. Besides the fact that antibiotics kill off beneficial bacteria in the intestines, misuse of antibiotics provides an opportunity ...
Antibiotic resistance evolves naturally through natural selection via random mutation, but it could also be engineered by applying an evolutionary stress on a population. The antibiotic action is an environmental pressure; those bacteria which have a mutation allowing them to survive will live on to reproduce. They will then pass this trait to their offspring, which will be a fully resistant generation. Studies at the Finnish Academy found that using one type of antibiotic increases the resistance of bacteria to other types of antibiotics as well. Antibiotics do not work against illnesses t...
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
Misuse or overuse of antibiotics plays a key role as to why bacteria have become resistant to antibiotics. With antibiotics easily available these days people will s...
...earch in this area. Plus, we also need to become better consumers for our own personal antibiotic use because bacterial infections can also derive from misuse and overuse of an antibiotic drug. We must prevent the spread of bacteria by washing our hands, fruits, and vegetables. Even raw eggs and undercooked meat are suspects in creating bacterial infections. Furthermore, to be properly vaccinated is a major fight against such infections. So “although humans are not yet close to winning the war against S. aureus, these measures may help provide the weapons we need to have a fighting chance” (Freeman-Cook and Freeman-Cook 2006). Perhaps, one day in the near future the fight against bacterial infections will be resolved and there will no longer be a need for posing the hypothesis of “Why Methicillin-Resistant Staphylococcus Aureus (MRSA) is antibiotic-resistant.”
Bibliography:.. References 1) Lewis, Ricki, “The Rise of Antibiotic-Resistant Infections”. Food and Drug Administration Publications. http://www.fda.gov/fdac/features/795_antibio.html September, 1995. 2) Levy, S., Bittner, M., and Salyers, A. Ask the Experts about “Ask the Experts”.
Discovery and Development of Penicillin. (2014, April 4). Retrieved from American Chemical Society International Historic Chemical Landmarks: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
Penicillin, the first antibiotic, was discovered accidentally by Sir Alexander Fleming in 1928. Sir Fleming was growing bacteria on agar plates and accidentally left one of the plates open. A mould started growing on this. Fleming noticed that no bacteria grew
Exposure to antimicrobials fundamentally alters microbial ecosystems of humans, animals and the environment, which may lead to the development of antimicrobial resistance.