The Anatomy of the Appendix

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Dating back to the Renaissance, many scientists have taken special interest in the appendix, with the first drawings of the appendix in 1492 and later the first description of the appendix in 1521(Prystowsky, Pugh & Nagle, 2005). The function of the appendix in the adult human is still unclear, but it is likely related to the role of the lymphoid tissue in immunologic processes (Debas, 2004). It was not until 1711 that the first account of appendicitis was reported and then verified in an autopsy of a criminal (Prystowsky, Pugh & Nagle, 2005). In this account, appendicitis was described as a gangrenous appendix with a small perforation. Today, appendicitis is deemed as an inflammation of its inner lining that has the ability to spread to its other parts. Interestingly enough, the cause of appendicitis remains unknown, as over half of the cases of appendicitis remain elusive, but regardless of the specific details of the specific case of appendicitis or of the decided course of treatment, there is universal agreement that the best outcomes of acute appendicitis are associated with early diagnosis.
In order to understand the pathophysiology of appendicitis, one must first have a general understanding of the anatomy of the appendix. The appendix arises from the cecum, and like the cecum, includes circular and longitudinal muscle layers (Prystowsky, Pugh, & Nagle, 2005). Additionally, the appendix contains many lymph follicles in its submucosa. The appendix lays approximately 2.5 cm below the ileocecal valve and is usually 5 to 10 centimeters in length with an average width of 0.5 to 1 centimeter. Although part of the appendix appears to be continuous with the cecum, the remainder of the appendix is free, which accounts for its va...

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... back to the Renaissance, appendicitis is a common condition occurring in 250,000 United States patients yearly (Prystowsky, Pugh, & Nagle, 2005). Along with its controversial cause, the diagnosis of appendicitis can be tricky. The diagnosis of appendicitis can be made through a physical examination or with imaging techniques, but no matter how appendicitis is diagnosed, it is always vital that appendicitis be caught early on in the disease. The combination of an early diagnosis and surgical treatment promises the expulsion of the progression of the disease prior to the point of perforation, which is associated with increased morbidity. However, the diagnosis of appendicitis does become more difficult in atypical cases, such as those involving the elderly, young children, those with a uniquely placed appendix, or with those with a complicated medical history.

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