Teratomas

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Envision, a tumor so repulsive, it violates the very laws of physiology, turning normal tissues at odds with their own nature. According to Merriam Webster, a teratoma is defined as a tumor derived from more than one embryonic layer and made up of a heterogeneous mixture of tissues, such as epithelium, bone, cartilage, or muscle. The name teratoma, originates from the ancient greek prefix of terato, meaning monster, combined with the suffix oma, meaning mass. Therefore, it can be interpreted, the phrase teratoma, denotes a monstrous mass. Indeed, teratomas, are of grotesque quality, seeing as they are not limited by normal anatomical boundaries. Even more, they may even contain hair, teeth, fat, bone, and sometimes complex organs (see fig 1).

The etiology of a teratoma is still not fully understood, since it pertains to the category of germ cell tumors. Even so, teratomas are most commonly found in certain organs, such as the brain, thyroid, liver, lungs, ovaries, and testes. Subsequently, teratomas are believed to be caused by the abnormal development or migration of either germ cells or embryonic (stem) cells during embryogenesis. If the teratoma is of germ cell origin, then it will be located in either the testes or ovaries. However, if it is derived from embryonic cells, then it can be located anywhere from the sutures of the skull, all the way down the coccyx. With this in mind, embryonic teratomas are congenital, which means they either exist before birth, at birth, or develop within one month after birth. Germ cell teratomas, are not believed to be congenital, but this is not known for certain.

Although, most teratomas are benign due to being encapsulated, some have to the potential to be malignant. Moreover, a teratoma can be categorized into one of two groups, mature and immature. A mature teratoma is usually benign, and is either solid, cystic, or both (see fig 2). Mature teratomas differentiate highly, and contain all types of tissues. A specific kind of mature teratoma that commonly contains hair follicles inside, is known as a dermoid cyst, and is occurs mostly in the ovaries and in the sutures of the skull (see fig 3).

An immature teratoma is a type of malignant germ cell tumor, and can contain the same entities as a mature teratoma, with the exception of containing primitive neuroepithelial, which is considered to be the “stem cells” of the nervous system.

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