The Article Analysis of Pancreatic Mitochondrial Complex I Exhibits Aberrant Hyperactivity in Diabetes by J’Lyrick Woods
The purpose of this study, Pancreatic Mitochondrial Complex I Exhibits Aberrant Hyperactivity in Diabetes, is to establish that an increase of the stimuli in the pancreatic mitochondrial Complex I leads to diabetes. Increasing the stimuli of Complex I, subsequently raises the levels of reactive oxygen species and oxidative stress. Complex I, also known as NADH, is the first step of the respiratory electron transport chain which use protons to pump proteins creating most of the energy that helps power cells. This complex uses molecules to create an electrochemical gradient in our mitochondria, which is powered by the production of NADH by breaking down food molecules, helping to power ATP Synthase. Diabetes mellitus is a chronic disease in which the body’s ability to use energy produced by food intake is affected, causing an increased level of blood sugar. Hyperglycemia glucotoxicity is high blood sugar, which damages the structure and function of beta cells and target tissues of insulin, causing a low level of hormone secretion and insulin resistance. In this experiment, rats and mouse were collected to be injected with different dosages of Streptozotocin (STZ), a
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Along with complex I becoming increasingly active once beta cells were exposed to a high concentration of glucose versus a normal concentration. Beta cell complex I activity was also increased, concluding that the increased complex I activity may have occurred from diabetic beta cells. The activity levels of complex I, II, and IV have proven to have an increase, while complex V shows no signs of an increase, nor any changes between diabetes and healthy
The beta cells affect a person’s glucose regulations within the blood. This is because the beta cells are in charge of sending insulin arou...
According to Lewis and associates, DM is a chronic disease that affects multiple body systems. For the purpose of this paper, only DM type 2 will be discussed based on the assumption that a majority of patients aged 60 years or older have this type. The primary defects of this disease consist of insulin resistance, decreased insulin production, inappropriate glucose production by the liver, and alterations in production of adipokines. Insulin resistance is the result of defects in the body’s insulin receptors. This finding predates all cases of DM type 2 and the development of impaired glucose tolerance. In insulin resistance, beta cells in the pancreas are stimulated to increase insulin production to compensate for the lack of response by the insulin receptors. Gradually, the beta cells begin to fail to secrete enough insulin to meet the body’s demands resulting in hyperglycemia. As a result of increased glucose in the liver, the liver begins to malfunction and release glucose at inappropriate times, thereby worsening hyperglycemia. Adding to the problem, glucose and fat metabolism is altered in adipose tissue, which is generally abundant in those with DM type 2. (Lewis et al., 2011)
The pancreas is an elongated and flattened gland located within the abdomen. Not only is it a vital part of the digestive system, but it is also a key controller of blood sugar levels. (The Pancreas). The pancreas has been divided into four regions which are the head, neck, body, and tail. Being the widest part of the pancreas, the head is twenty-three millimeters. The part of the head that hooks towards the back of the abdomen is the uncinate (Chronic Pancreatitis Imaging). Between the head and body of the pancreas is the neck, which is about nineteen millimeters. The body of the pancreas is twenty millimeters, between the neck and the tail. The tail is the smallest part of the pancreas, measuring at only fifteen millimeters. (Parts of the Pancreas). The length of the pancreas in total ranges from four point seven to seven point one inches. The pancreas also weighs from seventy to one-hundred grams (How does the Pancreas Work?).
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
The first evidence of diabetes was found on an early Egyptian manuscript from 1500 BCE, however; it is only in the last 200 years that we understand what is happening at the cellular level in a diabetic individual (Polansky, 2012). We now know that diabetes is a complex disorder of genetic, chemical, and lifestyle factors that contribute to the body’s inability to utilize glucose for energy and cellular functions (ADA, 2013).
“An Examination of Animal Experiments.” Physician Committee for Responsible Medicine. N.p., n.d. Web. 13 Feb. 2014. .
Diabetes refers to a set of several different diseases. It is a serious health problem throughout the world and fourth leading cause of death by disease in the country. All types of diabetes result in too much sugar, or glucos in the blood. To understand why this happens it would helpful if we understand how the body usually works. When we eat, our body breaks down the food into simpler forms such as glucose. The glucose goes into the bloodstream, where it then travels to all the cells in your body. The cells use the glucose for energy. Insulin, a hormone made by the pancreas, helps move the glucose from bloodstream to the cells. The pathophysiology of diabetes mellitus further explains the concept on how this disease works. Pancreas plays an important role of the metabolism of glucose by means of secreting the hormones insulin and glucagon. These hormones where then secreted by Islets of Langerhans directly to the blood. Inadequate secretion of insulin results on impaired metabolism of glucose, carbohydrates, proteins and fats which then result to hyperglycemia and glycosuria. Hyperglycemia is the most frequently observed sign of diabetes and is considered the etiologic source of diabetic complications both in the body and in the eye. On the other hand, glucagon is the hormone that opposes the act of insulin. It is secreted when blood glucose levels fall.
Glucose is a sugar that plays a big part in a human’s health and well-being. This sugar is a major source of energy for the body’s brain and cells. The Cells that receive energy from glucose help in the building of the body’s muscle and tissue. Although glucose may be important to the body too much of this sugar can cause a chronic condition called Diabetes. Diabetes, also known as Diabetes mellitus, is a chronic condition that is caused by too much sugar in the blood. This condition can affect all age groups. In fact, in 2010 a survey was taken by the National Diabetes Information Clearinghouse, on the number of newly diagnosed diabetes. Out of 1,907,000 people: 24.38% were ages 20-44, 55.17% were ages 45-64, and 20.45% were ages 65 and greater. Diabetes is a very serious condition, and it can be deadly if left untreated. This paper will help better educate the reader on the signs and symptoms, the testing process, and the management of diabetes.
Haplogroups M and N arose from the L3 line, and these populations migrated. The haplogroup M lineage can be found in Asia and gave rise to lineages C, D, G, Q, and Z, while the haplogroup N lineage predominantly moved to Europe, and gave rise to haplogroup A, I, W, X, and R. R eventually became the root of European haplogroups B, F, H, J, T, U, and P. While these account for the major haplogroup types, there are also a plethora of sub-haplogroups that have arisen from each major haplogroup type (Stewart & Chinnery, 2015). Within our lab, we sought to sequence a known hypervariable region within our individual mitochondrial DNA to determine which ancestral line was inherited from our maternal side. To accomplish this, we isolated our genomic DNA from cheek cells, amplified the target region using a PCR reaction, completed a gel electrophoresis reaction to ensure a good PCR product, the PCR product was cleaned, then sent for sequencing.
Diabetes type 1 occur when the immune system destroys the beta cells, they are responsible to create insulin and are located
Diabetes is a chronic disorder of metabolism characterized by a partial or complete deficiency of the hormone insulin. With this, there are metabolic adjustments that occur everywhere in the body. Specific to this child is Type One Diabetes. This is characterized by demolition of the pancreatic beta cells, which produce insulin. Because of this, it leads to complete insulin deficiency. Within Type One diabetes, there are two different forms. First there is immune-mediated deficiency, which typically results from an autoimmune destruction of the beta cells. The second type is called idiopathic type one, in which the cause is unknown. (Wong, Hockenberry, Wilson, 2015)
The mitochondria is an organelle which is generally an oval shape and is found inside the cytoplasm and is again apart of the eukaryotic cells. The main function of the mitochondria is to complete cellular respiration; in simple terms it acts like a digestive system to break down essential nutrients and to convert it into energy. This energy is usually found to in ATP which is a rich molecule taken from the energy stored in food. Furthermore, mitochondria stores calcium for signalling activities; such as heat, growth and death. They have two unique membranes and mitochondria isn’t found in human cells like the red blood cells yet liver and muscle cells are filled entirely with mitochondria.
Mitochondria are organelles in cells that provide energy, and they have their own DNA. Sometimes, mitochondrial DNA has mutations in it, causing rare, deadly, and incurable diseases. Women who have defective mitochondria can pass these diseases onto their children, but mitochondrial replacement therapy allows these women to have healthy babies that are free from mitochondrial disease.
From my reading I learned that cellular respiration is a multi-step metabolic reaction type process that takes place in each living organism 's cell rather it be plant or animal. It’s my understanding that there are two types of cellular respiration, one called aerobic cellular respiration which required oxygen and anaerobic cellular respiration that does not require oxygen. In the anaerobic cellular respiration process, unlike the aerobic process oxygen is not required nor is it the last electron acceptor there by producing fewer ATP molecules and releasing byproducts of alcohol or lactic acid. The anaerobic cellular respiration process starts out exactly the same as anaerobic respiration, but stops part way through due to oxygen not being
Cells are the basic building blocks of all living things. The human body is composed of trillions of cells. They provide structure for the body, take in nutrients from food, convert those nutrients into energy, and carry out specialized functions. But it also contains highly organized physical structures which are called intracellular organelles. These organelles are important for cellular function. For instance Mitochondria is the one of most important organelle of the cell. Without Mitochondria more than 95% of the cell’s energy, which release from nutrients would cease immediately [Guyton et al. 2007].