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Multiple sclerosis research paper
The central nervous system
The central nervous system
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Cody Munoz The human body is amazingly physically capable and is able to create a number of complex movements and generate varying amounts of force, with varying speed and control of the movement due to the function of the body’s Central Nervous System. The Central Nervous System transmits messages from the brain to the part of the body a person wishes to move by using nerve fibers very rapidly, and this results in humans being able to complete a number of complex movements in very controlled manners and at considerably fast paces. However, sometimes the transmission of messages from the brain to the Spinal Cord can become disrupted, and this leads to less control of movements and can lead to movements becoming slowed down or even stopped …show more content…
This trial looked at improvements in a timed 25-foot walk and had an evaluator examine the improvement of each individual’s hip flexor strength, knee flexor and extensor strength, and ankle dorsiflexor strength. Like the test in the previous trial, these tests were designed to investigate improvement in muscle coordination and function, both of which generally decrease for those afflicted with Multiple Sclerosis. In the study, one group took a placebo sugar pill while the other group took 10mg of Fampridine-SR twice daily for 9 weeks. 119 participants received the 10mg of Fampridine-SR, and 118 received the placebo sugar pill. The results showed that there were 51 responders to the Fampridine-SR group, and 11 responders to the placebo group. This is very significant and indicates that Fampridine-SR could be very useful for treating symptoms of Multiple Sclerosis. The results also showed a somewhat significant difference in the evaluator tests. For the Fampridine-SR regiment, results showed a difference of .09 and the placebo group showed a difference of .04 based on the evaluator scale, which was designated to have a minimum of 0 and a maximum of 5. This shows Fampridine-SR could be effective in treating both the primary and secondary outcomes measured during this trial. There were adverse events in 5% of the Fampridine-SR participants and 3.36 % of the placebo group. This is a very insignificant difference when compared to the placebo group so there is not too much concern about these events and the results didn’t indicate there was any safety issue. The results of both of these clinical trials show that Fampridine-SR can be effective in treating symptoms of Multiple Sclerosis, specifically
With MS, most people experience exacerbations, where symptoms get progressively worse, which are then “followed by periods of reduced or no symptoms,” indicative of remission (PubMed Health 2013). Though for many it is “common for the disease to return (relapse), […for some] the disease may continue to get worse without periods of remission” (PubMed Health 2013). Also, the severity of the disorder can be amplified by exposure to extreme heat in addit...
According to National Multiple Sclerosis Society, Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain and body. The central nervous system (CNS) comprises of the brain and the spinal cord. CNS is coated and protected by myelin sheath that is made of fatty tissues (Slomski, 2005). The inflammation and damage of the myelin sheath causing it to form a scar (sclerosis). This results in a number of physical and mental symptoms, including weakness, loss of coordination, and loss of speech and vision. The way the disease affect people is always different; some people experience only a single attack and recover quickly, while others condition degenerate over time (Wexler, 2013). Hence, the diagnosis of MS is mostly done by eliminating the symptoms of other diseases. Multiple sclerosis (MS) affects both men and women, but generally, it is more common in women more than men. The disease is most usually diagnosed between ages 20 and 40, however, it can occur at any age. Someone with a family history of the disease is more likely to suffer from it. Although MS is not
Diagnosis is the process of identifying a particular condition via a systematic way. Differential diagnosis is the method of pinpointing all possible aetiological factors that are related with all clinical signs and symptoms and thus, precisely differentiating diagnosis until an accurate conclusion is made. Differential diagnosis is essential especially in field of neurology where many diseases share similar characteristics but has no definite examination or neurological test: Parkinsonism, migraine, amyotrophic sclerosis and also, multiple sclerosis.
Patients are presented with Multiple Sclerosis in various different forms and experience symptoms to different degrees – mild, moderate or severe. While some patients’ predominately experience emotional or cognitive dysfunction, others may be presented with loss of muscle control, and/or visual, balance and sensation symptoms. Other symptoms include fatigue, bladder and bowel problems.
Multiple Sclerosis is a nervous system disease that affects the spinal cord and the brain by damaging the myelin sheaths that protects nerve cells. Destroyed myelin prevents messages from communicating and sending properly from the brain, through the spinal cord, to internal body parts. In the United States, more than 350,000 people are diagnosed with this disease. Anyone can get this disease, but it is more common among Caucasian women. MS symptoms begin between the ages 20-40 and are caused by nerve lesions being present in multiple areas of the Central Nervous System, symptoms differ on the lesion’s location.
The spinal cord is a major channel in the body where motor and sensory information travels from the brain to the body. It has white matter that surrounds a central gray matter. The gray matter is where most of the neuronal cells are located. Injury to the spinal cord will affect the conduction of information across any part of the spinal cord where the damage is located (Maynard et al., 1997). This will often result in permanent disability of a certain muscle or region of the body (Meletis et al., 2008) and a loss of tissue where the damage is located (Peng et al., 2009). As of now, there is no treatment for spinal cord injury expect for steroids. All steroids can do is provide protect of the spinal cord from secondary injury for specific patients (Peng et al., 2009).
Multiple sclerosis was first discovered in 1868 by a neurologist by the name of Jean Martin- Charcot. Multiple sclerosis receives its name from the distinctive areas of scar tissue with the formation of damaged myelin sheaths. Multiple Sclerosis is referred to as an immune- mediated response that targets the central nervous system, including the spinal cord, the brain, and other parts of the body. The central nervous system is usually targeted by an abnormal response to the human body’s immune system causing an attack on the myelin coated fibers around nerve fibers. Generally, this occurs due to inflammation of myelin in the brain, causing lesions or plaques to form. Since myelin sheaths in the nervous system are there to increase nerve impulses,
It is clear that Multiple Sclerosis is a dreadful disease. Its multiple variations not only induce neurological debilitation but it can also bring about other disorders. Unfortunately, a cure hasn’t been created yet but medications and a healthy lifestyle can make the victim’s life much easier.
(1) One third of a million Americans suffer from MS and a great percentage of those people are women. Women account for 73% of MS sufferers. (2) MS usually strikes young adults between the ages of 20 and 40 years old. (8) There are even some cases of MS being diagnosed in childhood.
The human body relies on a system of electrical impulses and nerves known as the Central Nervous System. This system is dependent on an organization of complex neurons, which are specialized cells that is responsible for sending, receiving, and interpreting the information from every part of the body. And surrounding each neuron is a thin layer of tissue known as the myelin sheath, which insulates the neurons and prevents electrical impulses from leaking. Even though, the neurons are shielded, they can still be damaged. The body’s immune system can attack the protective myelin sheath, which is known as the process of demyelination. The loss of the sheaths causes the electrical impulses to pass more slowly and overtime they become damaged and
Multiple Sclerosis (MS) is a debilitating autoimmune disease. The Central Nervous System (CNS) is attacked by the immune system; creating lesions that interrupt the correct signaling of nerves, spinal cord, and brain (Frankel, & James, 2011). Inhibiting development of this disease is crucial for maintaining quality of life and fatigue for individuals with MS. There has been vast amount of research on the effect of various exercise training programs, and their benefits for MS (Motl, & Gosney, 2008, Krupp, 2003, Chen, Fan, Hu, Yang, & Li, 2013). Balance, aerobic, and strength training have been the main focus of most researchers; causing an interest in what training mode is most effective for improving quality of life and lower fatigue. It is critical to examine and contrast the effectiveness of a variety of exercise programs, because if training is completed effectively it can drastically improve quality of life and fatigue for individuals with MS.
Multiple Sclerosis also known as “MS,” is a neurological disease that affects the central nervous system targeting the brain, spinal cord and nerves within our eyes. Studies have shown that MS affects more women than it does men typically from the age of 20-50 years old. According to stats from “The Multiple Sclerosis Foundation,” there is an estimate of 400,000 Americans currently living with MS. Some doctors believe that the difference between the male and female brain is the link as to why more women are diagnosed. Researchers at Washington University School of Medicine in St Louis have discovered a protein called “S1PR2”, which could be an association with Multiple Sclerosis. Through different tests and experiments these scientists found that women produce a higher level of this protein and that could be a key component as to why women are more likely at risk of contracting this disease. This disease affects each individual differently and it’s unpredictable as to who may be the next victim. Although MS is not hereditary, having a parent, brother or sister with it could increase a person's chances of developing it.
Multiple Sclerosis (MS) is “a chronic, degenerative, progressive disease of the central nervous system characterized by the occurrence of small patches of demyelination in the brain and spinal cord” (Smeltzer & Bare, 1996). Over 2 million people are diagnosed with MS and it is known that there is a link between geography and the diagnosis of this disease (Faguy, 2016). In personal interviews with the patient and his wife, discussions were held about the disease process for this patient; medications were reviewed, and the spiritual assessment was conducted. This paper will discuss the current genetic information, disease modifying drugs and spiritual belief of one patient with chronic Multiple Sclerosis.
In an article entitled “Multiple Sclerosis: Why Exercise,” Connie Brichford brings out the importance of regular physical activity and exercise for people with multiple sclerosis (MS). Originally, exercise for people with MS was not recommended due to the risk of exacerbating their conditions, however recent studies have revealed that physical activity and exercise can help limit the effects of this devastating disease. Brichford also emphasized the importance to designing specialized exercise plans with the guidance of a physical therapist and doctor for each individual case. Kathleen Costello, a clinical care vice president of the National Multiple Sclerosis Society, advocates that individuals with MS select exercise routines
L. R. Hochberg, M. D. (2006). Neuronal ensemble control of prostetic devices by a human with tetraplegia. Nature, 164-71.