Introduction Multiple Sclerosis (MS) is one of the most common diseases of the Central Nervous System (CNS) which affects all ages and gender. MS is currently the leading cause of disability in young adults and found to be more prevalent in women and affects 2.5 million people worldwide. “Multiple Sclerosis is a progressive chronic immune - mediated disease characterized by disseminated demyelination of nerve fibers of the brain and spinal cord” (Mahan, Escott-Stump, 2008). MS was discovered in 1868 by Jean-Martin Charcot, at the time he was treating a female patient for tremors. Charcot began noticing similar neurological problems as his other patients and after the patient died he conducted an examination on her brain and discovered …show more content…
The MS Sociey bridged several gaps between neurologists, patients with MS, and the funding needed to advance in research. In 1947 Dr. Elvin Kabat at Columbia University identified abnormal immunologic proteins in the spinal fluid of people with MS. With the information already obtained in previous studies relating the Oligoclonal bands to proteins in the spinal fluid immune system and MS could now be connected. By the 1960’s neurologists and scientists were able to make an accurate diagnosis and measure how therapies could affect disability. A group of patients who were experiencing exacerbations (flare ups) were given adrenocorticotropic (ACTH) hormone (a hormone normally produced by the pituitary gland). The goal was for the ACTH to have anti-inflammatory and immune-suppressing effect. In comparison to the placebo group the hormone was a success. In 1978 CAT scans were performed and helped in the diagnosis of MS. Then in the 1980’s CAT scanning was replaced with the MRI scan which showed the brain in greater detail. Also in the 1980’s, there were several new treatment trials taking place. From 1990-current scientists have been able to show white blood cells (T cells) as having a direct correlation to MS. Neurons and axons were identified as being damaged leading to disability. There were improvements made in medications for symptom management and by 1993 the first injectible medication, Copaxone …show more content…
However, a number of well-established findings have been incorporated into a hypothesis to explain the etiology of MS (Mahan & Escott-Stump, 2008). “Although a familial predisposition to MS has been noted in a minority of cases, familial tendency is not well established' no consistent pattern of Mendelian inheritance has emerged” (Victor & Ropper, 2005) (p.1093). MS is known to be a immune - mediated demyelinating, progressive disease the affects the CNS. The term Multiple Sclerosis is called multiple because multiple areas of the optic nerves, spinal cord, and brain undergo “Sclerosis” where myelin is replaced with sclera or scar
Mairs’ piece is a careful examination of her experience with MS and her perspective towards her future. In contrast, Soyster writes humorously of a particular incident he had with MS and artfully weaves his ideas about the disease in with his story. In both instances, the authors share the purpose of narrating their encounter with MS to the world to raise awareness.
Multiple sclerosis (MS) is a disease affecting the myelination of the central nervous system, leading to numerous issues regarding muscle strength, coordination, balance, sensation, vision, and even some cognitive defects. Unfortunately, the etiology of MS is not known, however, it is generally thought of and accepted as being an autoimmune disorder inside of the central nervous system (Rietberg, et al. 2004). According to a study (Noonan, et al. 2010) on the prevalence of MS, the disease affects more than 1 million people across the world, and approximately 85% of those that are affected will suffer from unpredictably occurring sessions of exacerbations and remissions. The report (Noonan, et al. 2010) found that the prevalence of MS was much higher in women than in men, and that it was also higher in non-Hispanic whites than in other racial or ethnic groups throughout the 3 regions of the United States that were studied.
Around the world, many people are living with neurologically debilitating disorders like multiple sclerosis. Multiple sclerosis is best described as a pathological “inflammatory-mediated demyelinating disease of the human central nervous system,” and affects more than 2.5 million people globally (Trapp & Nave, 2008).
Well what causes MS? When you have damaged nerve signals that is one way you can get it. Another way is you is it could be genetic or environmental. The other way you can cause it is by infections. Woman would be more common to get MS than a man. The ages
Multiple sclerosis - is an autoimmune disorder that affects the central nervous system including the spinal cord and brain.
According to National Multiple Sclerosis Society, Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain and body. The central nervous system (CNS) comprises of the brain and the spinal cord. CNS is coated and protected by myelin sheath that is made of fatty tissues (Slomski, 2005). The inflammation and damage of the myelin sheath causing it to form a scar (sclerosis). This results in a number of physical and mental symptoms, including weakness, loss of coordination, and loss of speech and vision. The way the disease affect people is always different; some people experience only a single attack and recover quickly, while others condition degenerate over time (Wexler, 2013). Hence, the diagnosis of MS is mostly done by eliminating the symptoms of other diseases. Multiple sclerosis (MS) affects both men and women, but generally, it is more common in women more than men. The disease is most usually diagnosed between ages 20 and 40, however, it can occur at any age. Someone with a family history of the disease is more likely to suffer from it. Although MS is not
For CSF, 6 of 62 MS patients, and 1 of 40 controls, were positive for ETX immunoreactivity. For the analysis of sera, 6 of 56 MS patients, and 0 of 60 controls were seroreactive to ETX.
Multiple Sclerosis (MS) is a complicated chronic deteriorating disease that has an effect on the central nervous system (CNS). This disease causes destruction of the myelin around the nerve fibers. “The exact etiology of Multiple Sclerosis is unknown; however, it is thought to be an immune mediated disease. MS is characterized by CNS inflammation, demyelination, and axonal loss” (Compston & Coles, 2008). Typically, it is described by early relapses and remissions of neurological signs of the CNS. This is known as relapsing-remitting MS (RRMS). MS can be identified by a variety of known risk factors. Multiple Sclerosis can be brought on by a mixture of inherited and environmental risk factors such as smoking or an exposure to a virus like Epstein Barr. The inflammatory process has an interesting role on the central nervous system.
Primarily, the term MS refers to a chronic disorder that attacks the central nervous system (CNS). It is most common in temperate continents such as Europe and Australia with Asiatic and African continents having a lower risk of the disease (Wiley Online Library, 2013). A search organised by the Multiple Sclerosis Society (2013) has estimated that there are 127,000 people living with MS in the United Kingdom. Further research by Chipps, Clanin, and Campbell (1992, pp. 158-167) shows that MS disorder more likely affects women than men with its symptoms occurring between the ages of 20 and 40 in most cases and is quite uncommon in childhood and old age. The nerve cells known as neurons in the brain constantly transmit and receive signals. They invoke emotions, activities and cognition that constitute the day to day experiences of humans. Under normal circumstances, these signals travel on a protected insulation path known as the myelin sheath. This insulation is vital as it enables signals to reach their target. In Multiple Sclerosis, the myelin sheath gets disintegrated causing the nerve fibre to be damaged leading to a disruption in the abili...
Multiple sclerosis is a chronic disease of the central nervous system. It is understood as an autoimmune disease, a condition where the body’s immune system mistakenly attacks normal tissues. In Multiple Sclerosis, the patient’s own cells & antibodies attack the fatty myelin sheath that protects and insulates nerve fibres in the brain and spinal cord, the two components of the CNS. This ultimately causes damage to the nerve cells and without the insulation the myelin sheath provides, nerve communication is disrupted. Hence, Multiple Sclerosis is characterized by symptoms that reflect central nervous system involvement (Luzzio, 2014).
Multiple sclerosis, also known as MS, is one of the humankind’s most mysterious diseases. Multiple sclerosis has the ability to affect nearly 3 million people worldwide. This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men are. Of those 3 million people, most of them are between the ages of 20 and 50 years old. Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.
Multiple Sclerosis is a nervous system disease that affects the spinal cord and the brain by damaging the myelin sheaths that protects nerve cells. Destroyed myelin prevents messages from communicating and sending properly from the brain, through the spinal cord, to internal body parts. In the United States, more than 350,000 people are diagnosed with this disease. Anyone can get this disease, but it is more common among Caucasian women. MS symptoms begin between the ages 20-40 and are caused by nerve lesions being present in multiple areas of the Central Nervous System, symptoms differ on the lesion’s location.
The discovery of meningitis dates back to the 1800’s. The first evidence that linked bacterial infection as a cause of meningitis was written by Austrian pathologist Anton Weichselbaum. He was the one to isolate the causative agent of cerebrospinal meningitis. He named this bacterium Diplococcus intracellularis meningitidis.
Multiple Sclerosis (MS) is a debilitating autoimmune disease. The Central Nervous System (CNS) is attacked by the immune system; creating lesions that interrupt the correct signaling of nerves, spinal cord, and brain (Frankel, & James, 2011). Inhibiting development of this disease is crucial for maintaining quality of life and fatigue for individuals with MS. There has been vast amount of research on the effect of various exercise training programs, and their benefits for MS (Motl, & Gosney, 2008, Krupp, 2003, Chen, Fan, Hu, Yang, & Li, 2013). Balance, aerobic, and strength training have been the main focus of most researchers; causing an interest in what training mode is most effective for improving quality of life and lower fatigue. It is critical to examine and contrast the effectiveness of a variety of exercise programs, because if training is completed effectively it can drastically improve quality of life and fatigue for individuals with MS.
The nervous system plays a major role in co-ordinating and controlling the body’s activities. It is made up of billions of nerve cells. These cells are linked to form a massive communications network. Nerve cells carry messages in the form of electrical impulses. These impulses are carried at high speed around the body to keep it safe and functioning normally. Multiple sclerosis (MS) is a disease which progressively injures the nerves of the brain and spinal cord. Injury to the nerves in multiple sclerosis may be reflected by alterations of virtually any sensory or motor (muscular) function in the body.