As proton pump inhibitors (PPIs) Omeprazole and Lansoprazole are effective therapeutic agents for Peptic ulcers. But which one is more effective as a PPI and highly useful for peptic ulcers disease. The basis of the distinction lies in the pharmacological safety and efficacy of each PPI, which is assessed in this paper in a head to head comparison. After obtaining the relevant literature from Database PubMed and Proquest, it is sufficient to conclude that Lansoprazole proved to be a more effective and safe than Omeprazole. INTRODUCTION The stomach naturally produces acid, which is mainly responsible for food digestion and the destruction of any foreign pathogen or bacteria ingested with food. Acid is secreted by stimulating the partial …show more content…
Both ulcers have the same physiology but what distinguishes them is the location, GU is located in the stomach and DU is located in the duodenal part of intestine. There are many factors that may cause peptic ulcers such as chronic use of non-steroidal anti-inflammatory drugs (NSIADs), smoking, excessive drinking, and excessive gastric acid secretions caused by tumors1. There are three types of treatments to peptic ulcers antacids, antihistamine, and proton pump inhibitors (PPI). The most important and most effective remedy is the PPI, which is the strongest type of medicine out of the three types. PPIs work by inhibiting the release of protons (hydrogen ions) from the parietal cells (the source of acid secretion) to the lumen of the stomach1. There are many several types of PPI for the purpose of this research we will examine the efficacy of only two Omeprazole and …show more content…
For example in the article relating to the assessment of PPI specifically their efficacy and safety shows better healing rates of Lansoprazole in shorter-term3. This study had conducted clinical trails on patients with duodenal ulcers and the results shown better healing results with Lansoprazole than Omeprazole within 2 weeks. Nevertheless, the overall rates of healing were the same after 4 weeks. That is why the results were not significant according to the author because both drugs were able to achieve the same end result3. The author of this article presents similar publications by different authors to show that his results are consistent with their findings. This shows consistency in regards to better healing rates of Lansoprazole that were observed after a short period of time and the same overall equivalent end result of both
The pH of stomach acid ranges from 1 to 2 on the pH scale. The stomach constantly produces hydrochlo...
Patients were included in the trial if they met the following criteria: Patients that were in the ICU receiving proton pump inhibitors, either enteral or parenteral, regardless of frequency, dose or duration. The control group is H2 blockers by enteral or parental routes, regardless of frequency, dose or duration. Patients had to be considered critically ill and have at least one risk factor for stress ulcers. Exclusion criteria were based on evaluation of the randomized trials done many years ago. Trials that were eliminated were based on duplication, trials that were not relevant to research, trial involving pediatric population, quasi-randomized trials, abstract trials, and observational
The purpose of Ulcerative Colitis medications is to reduce inflammation in the colon, therefore giving the tissue a window to heal.
The purpose of the experiment was to examine the amount of acid neutralized by using an unknown sample of antacid.
Antacids may provide symptom relief but are not effective in healing peptic ulcer when use alone (Mayo Clinic, 2014).
...ve eaten, to break down the food into a liquid mixture and to slowly empty that liquid mixture into the small intestine. Once the bolus has entered your stomach it begins to be broken down with the help of the strong muscles and gastric juices which are located in the walls of your stomach. The gastric juices are made up of hydrochloric acid, water, and mucus- and the main enzyme inside of your stomach is what is known as pepsin, which needs to be surrounded in an acidic setting in order to do its job, that is to break down protein. Once the bolus has been inside of your stomach for long enough it begins to form into a liquid called chyme, and what keeps the chyme from flowing back into our esophagus are ring shaped muscles known as sphincters located at the beginnings and ends of the stomach and they have the task of controlling the flow of solids and liquids.
Omeprazole belongs to the family of medications called proton pump inhibitors (PPIs). It slows or prevents the production of acid within the stomach and is used to treat conditions where reduction in acid secretion is required for proper healing including stomach and intestinal ulcers (gastric and duodenal ulcers), the prevention and treatment of ulcers associated with medications known as NSAIDs, reflux oesophagitis, Zollinger-Ellison syndrome, heartburn, and gastro oesophageal reflux disease (GERD). Omeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and oesophagus to heal. This essay will discuss the therapeutic effect and uses of Omeprazole, its mechanism of action, administration and dosage, dose-related and non-d...
The food bolus goes down the pharynx a tube which connects the mouth to the esophagus. The esophageal sphincter then closes after food enters the esophagus and peristalsis moves food through the esophagus to the stomach. Then the gastroesophageal surrounding the cardial orifice opens and food enters the stomach. The stomach is a J-shaped, muscular pouch positioned in the abdomen. The stomach is made out of three layers of muscularis externa for mechanical digestion. Digestion in the stomach begins when it churns and mixes food with four secretions of the stomach wall which are hydrochloric acid (HCL) its task is to keep the stomach functioning properly maintaining the stomach acidic, mucus, inactive enzyme pepsinogen that is then converted into an active pepsin, pepsin enzyme works best in the acidic environment, pepsin also kills the bacteria that is swallowed along with your food at the time of ingestion. After the food has been broken down from solid material into liquid, also known as chyme. Chyme then exits the stomach through the pylorus into the small
The intestinal phase of gastric secretion and emptying occurs in the duodenum as a response to arriving chyme and is moderated by hormones ad nervous reflexes. It ensures that the composition and pH of chyme is correct before entering the intestines. Stretching of the duodenum enhances gastric secretion through the production of gastrin which stimulates gastric secretions. Decreased pH and lipids in the duodenum trigger chemoreceptors to send inhibitory signals to the stomach. Chyme in the duodenum also stimulate cells to release messengers that stimulate secretions in the pancreas and gall bladder. The compounds released work to suppress secretion in the gastric system and reduce the stomachs motility. This gives the duodenum time to process its contents before receiving more. The duodenum initially stimulates gastric function but then quickly works to inhibit it. This is a negative feedback system in that the receptors in the duodenum determine control the amount of material entering it through various
The hydrochloric acid in the stomach breaks down the sugars within the ingested food and chemically simplifies them. The acid is produced by the liver and is stored in the gall bladder (behind and under the liver). The now called bile then travels to the small intestine where vital nutrients are absorbed by the body and proteins are broken down in the duodenum. The large intestine is the next section and it absorbs all the water still retained in the processed material. When every possibly useful thing to the body is stripped from the bile, the substance is then excreted by the body through the rectum and
Lansoprazole medications are drug for proton pump inhibitor. By inhibiting the amount of proton pump, it will decrease the amount of acid produced in the stomach and will increase in pH. Lansoprazole is also to treat and prevent stomach and intestinal ulcers, esophagitis, which is damaged esophagus due to stomach acid and other conditions that involve in excessive stomach acid. Lansoprazole, however, is not treatment for immediate heartburn. Taking lansoprazole can also increase in risk of bone fracture such in the areas of hip or wrist. These are common side effects for proton pump inhibitors. Some of the other medications that can treat GERD include in some of antacids that neutralize stomach acids (Maalox, Mylanta) or medications that
Analysis of Aspirin Tablets Aim --- To discover the percentage of acetylsalicylic acid in a sample of aspirin tablets. ----------------------------------------------------------------- In order to do this, the amount of moles that react with the sodium hydroxide must be known. This is achieved by using the method of back titration.
Acid has a significant effect in the digestion of proteins. Gastric acid, whose main component is HCL, is secreted by the cells, which line the stomach as a primary response when proteins and fats are ingested. The main purpose of the acid is to break down the long chains of amino acid, however, this process is time consuming, therefore, digestive enzymes are secreted, which act as catalysts. Pepsin, Gastrin and gastric lipase are some of the enzymes that are
“Gastritis and an ulcer are conditions that affect the stomach and small intestine, and they share many symptoms, such as abdominal pain, nausea, vomiting, loss of appetite and weight loss” (Torrance Memorial Physician Network [TMPN], n.d.). Gastritis is considered generalized inflammation of the stomach lining (TMPN, n.d.). “Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine” (Mayo Clinic, 2017). While there are many similarities between the two conditions, there are also many differences. Both conditions can be caused by long-term use of nonsteroidal anti-inflammatory
The digestive system is very responsible for taking the whole food that people eat and turns them into energy and nutrients to allow the body to function, grow, and fix itself. The six primary processes of this system are ingestion of food, secretion of fluids and digestive enzymes, mixing and movement of food and waste throughout the body, digestion of food into small pieces, absorbing the nutrients, and the elimination of wastes. Ingestion is the first function of the digestive system, which is also known as the intake of food. The mouth is the reasoning for this process because through the mouth is the way food enters the body. The stomach and the mouth store food until your stomach is ready to digest the food that was just eaten. The reason why people can only eat a few times a day is because your body can only allow a certain amount of food depending on your body weight and type, and it cannot ingest more food than it can process at one time. The next step in Secretion, this happens in the course of the day. The digestive system secretes about 7 liters of fluid daily, but these fluids include saliva, mucus, hydrochloric acid, enzymes, and bile...