Jurassic Park Essay

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Ever since the movie “Jurassic Park” debuted, the world has wanted to know if dinosaurs can be genetically mutated from birds of today. Unfortunately, these experiments are not for creating dinosaurs, but to focus on a single trait to test a specific hypothesis on the evolution of development (Universidad De Chile 2016). Chickens have a reduced, splinter-like fibula that no longer connects to the ankle and is shorter than the tibia. This is the iconic drumstick of the chicken that we all have enjoyed at one point in time. While the chicken is developing in the embryo, it has been observed that birds develop a tubular fibula that is also and observed trait in dinosaurs. The lengthwise growth of the epiphysis occurs if the bone retains a cartilaginous …show more content…

As it continues to develop, the bone becomes spinter-like and the tibia continues to grow past it. To understand this transformation, Joao Botelho conducted two experiments: One focused on the fibular reduction in birds while the other focused on the development and evolution of the perching digit of birds.
In terms of fibular reduction, Botelho and his team studied the timing of reduction and ossification in several species of birds (Chicken, Mallard duck, and Chilean tinamou) (Botelho, 2016). They specifically looked at the molecular development of cartilage maturation and growth plate formation in the tibia and fibula. The key protein being Indian hedgehog (IHH) that was originally found in hedgehogs codes is produced by prehypertrophic chondrocytes. Its main role is endochondral ossification in most animals. It stimulates immature chondrocytes transition to hypertrophic chondrocytes that favor that replacement of cartilage to bone in the diaphysis. IHH has a negative feedback loop with Parathyroid hormone-related protein (PTHrP) that maintains the coordinated differentiation of immature chondrocytes in the growth plate (Botelho, 2016). If PTHrP is genetically inactivated,

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