Manipulation In The Uplift War

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Genetic Manipulation

In David Brins science fiction novel called The Uplift War, the reader is presented with a world in which humans have not only become a space faring species and made contact with extraterrestrials, but also made an astounding achievement on their own world; they have made dolphins and chimpanzees into thinking, sentient creatures through a process called uplift. Uplift is a process of elevating animal species to full sapience through methods of breeding and genetic engineering. The uplifted species, known as clients, then serve their patrons, the species who uplifted them, until the patrons release them from indenture. Naturally, this causes many problems. Client species are often looked upon as inferior; this is partly …show more content…

This method takes a lot of time and effort because the construction of the virus is quite complicated. Another effect of infection is that the information of the viruses may not always be incorporated into all the cultured cells, requiring out breeding of selected organisms to isolate those with the desired gene (Macer). Pronuclear microinjection is another method of genetic manipulation. Linear DNA fragments containing the desired gene are injected into the nucleus of a fertilized egg, where they will be incorporated at random locations. The desired gene will eventually be expressed in a percentage of resulting organisms. While relatively simple, there is still control over the expression rate of the genes or the disruption of genes vital to the organisms survival (Macer). Nuclear transfer is the most efficient method of genetic manipulation we have yet developed. Cultured cells are transfected with the desired genes; these cells can then be analyzed to determine whether the integration of DNA is successful. Selected cells are starved so they will not divide, then the nucleus is inserted into the original egg. The transgenic animal is then born, hopefully expressing the desired gene (Macer). The biggest concern about the methods of genetic manipulation is the large number of failures, that is, animals that dont express the desired gene. What will be done with the failures? Should they be killed, and would that be merciful, or cruel? Brin acknowledged human impatience, saying For all of their unusual and rapid successes in Uplift, Terran geneticists still had a way to go with neo-dolphins and neo-chimpanzeesby Galactic standards they had made great strides, but Earthmen wanted even more rapid progress (Brin, 110). Should we even attempt to evolve other species into full

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