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Buprenorphine case study
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Lasix
Pharmacokinetics
Lasix is known as the “water pill” it’s a diuretic administrated orally.(1) The active ingredient of Lasix is furosemide, but also includes a number of inactive ingredients including lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF. (1) The peak effects of furosemide are typically seen within the first hour of two after a dose of the medication. (1). Lasix is prescribed for individuals to treat edema that may arise from congestive heart failure, liver cirrhosis or renal disease. (1) In adults, furosemide may also be taken to treat hypertension itself.(1) Furosemide comes in 20, 40, and 80mg tablets as well as oral suspensions.(2) Furosemide is absorbed rapidly from oral suspension at 50 minutes, and from tablets at 87 minutes.(2) Food may slow down the absorption of the drug and alter the bioavalibitly.(1) Furosemide binds to plasma proteins, albumin being the main plasma protein that furosemide binds to, at 91-99%, and peak plasma concentrations increase with the increase of a single dose.(2) Furosemide is excreted through the urine and the remainder is excreted in the feces. (2) The half-life for furosemide is approximately 2 hours but the diuretic effects last 6-8 hours. (2)
Dosage Schedules and Routes of Administration
Furosemide is available in tablets, sublingual tablets, oral suspension, and intravenously. (2) The recommended schedule dose for adults for an initial dose is 20 to 80mg. (3) The same dose as well as higher doses may be administered 6 to 8 hours following the previous dose if needed. (2) When titrating doses it may be raised by 20 to 40mg but not within 6 to 8 hours after the initial dose, and this may continue until the desi...
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...hat makes the length of time the the medication is active much longer. (1) After opiates bind opiates are bound to the receptor a messanger such as cyclic AMP express the symptoms that are shown.(1)
Mechanism of Toxicity
Buprenorphine is contraindicated in patients with patients who opiate agnoist hypersensitivity.(1) It has been shown that CNS and repiratory depression macy occur with therapeutic doses of buprenorphine and can increase with ethanol intoxication.(1) Buprenorphine increass the tone and decreases the contractions of smooth muscles of the gastrointestinal tract resulting in constipation.(1) The metabolism of buprenorphine is directed by CYP3A4 isozyme, when administer with protease inhibitors it may decrease the clearance of buprenorphine.(1) This will increase the the levels of the medication in the plasma and can experience toxic effects(1)
Allegra 180 mg OTA - this medication should not make the patient drowsy and since he is a student it is helpful so that he does not get tired during class and can study.
...ould reconstitute to the final concentration of 100mg/ml first, then solution must be further dilute into 1mg/ml or 2mg/ml by adding 5ml of the original solution to 500ml or 250ml of normal saline or other compatible solution. It should be administer over 3 hours for 1mg/ml or over 1 hour for 2mg/ml for intermittent administration, and for oral form, it should be one hour before or two hours after meal. Beside that, a key thing to educate patient and family are to minimize direct sunlight during treatment, can only take magnesium or aluminum 2 hours before or after taking this drugs. On the other hand, when giving azithromycin to patient, the nurse should monitor for loose stool or diarrhea, monitor closely for PT and INR with concurrent use of warfarin, and especially report any sign and symptom of hypersensitivity because it can be serious even though it is rare.
Discuss the possible drug and excipient-related constrains of the formulation (no identity of the drug was given to you at this
According to Nutt (1997), rugs are used to produce alterations in brain function that act “on brain receptors and neurotransmitters” (p. 53). The areas of the brain where most of the drugs action takes place is beginning to be better understood in the past ten years, especially in the sense that drug abuse works through multiple mechanisms depending on the drug. Specifically looking at opioid abuse, the neurochemical action that takes place are agonists at the mu (µ) opioid receptors. Agonists mimic or increase the effects of a natural neurotransmitter. It often does this by binding to the receptor site triggering the same signals that the natural neurotransmitter would. The more an opioid does to interact with its designated receptor; the more efficient the agonist becomes (Nutt, 1997, p. 53). Simply, agonists work at a maximal efficiency.
Cocaine, a powdered narcotic derived from the leaves of the cocoa plant, has been a curious participant in the history of several contemporary cultures. Its ubiquity is an outgrowth of its unique and highly effective properties. While cocaine is commonly known as a highly popular recreational drug, its underlying chemical properties, chemical mechanisms, and chemical effects on the human body, offer an understanding of why the drug remains a resilient participant in today’s culture. We explore these chemical characteristics further.
Opiates based on their effects on the central nervous system of the body can reduce the pain, change the mood and behavior of the person. Thus, these drug lead to physical and psychological dependence. All around the globe drug abuse and dependence is becoming wildly common. Opioids drug dependence develops due to the effect of these drugs in alteration neurological functioning on temporary basis. Therefor, the risk of developing dependence when opioids are used in regular bases is sufficiently
Furosemide (Lasix) 40 mg daily in the morning: Loop diuretic used to treat edema associated with congestive heart failure (CHF).
Cocaine is a powerfully addictive drug of abuse. Individuals who have tried cocaine have described the experience as a powerful high that gave them a feeling of supremacy. However, once someone starts taking cocaine, one cannot predict or control the extent to which he or she will continue to use the drug. The major ways of taking cocaine are sniffing or snorting, injecting, and smoking (including free-base and crack cocaine).
Many people today view alcohol and drugs very differently than how they were portrayed years ago. In earlier years, there were not that many drugs that were used to save lives as the several different types of drugs that are used today. Today there are drugs used for different treatments for all kinds of diseases. Drugs are a business in which makes billions of dollars, both legally and illegally. Society views drugs majority of the time as something for saving lives, helping society for the better, but many don’t realize the millions of lives it’s destroying. Substance abuse from alcohol, illegal drugs to over the counter drugs and cigarettes can go from a casual once and a while thing to becoming an addiction. Substance abuse can be a huge gateway to addiction that can escalate very quickly. A lot of the time we convince ourselves that people chose to do these drugs so frequently, that addiction is a willing option they do to them-selves. Substance abuse and addiction are more than an individual problem it is a social issue.
Potent pain medication contains the aspects of utilizing medications such as morphine or demerol, how the medications are dispensed, and t...
First of all this research paper will examine the history of cocaine, answer exactly who used it, effects of the drug and its addictive nature. People choose to write about cocaine so that others can clearly see and understand its historical origins and dangerous properties. Those who experiment with drugs should become aware of their dangerous effects and take caution. The more people that become knowledgeable about cocaine, the more they can protect themselves from seriously endangering themselves. Cocaine users that are seriously dependent on the drug can seek treatment and rehabilitate. Most cocaine users do not realize they have a problem until it becomes too late. Much like the alcoholic, a cocaine dependent’s body has accepted the drug and is used to it being in the body’s system. When the body needs it, and the user does not have it, withdrawal takes place. In this case, a long, gradual process of lessening the dosage is the only route for success.
Drug abuse dates as far back as the Biblical era, so it is not a new phenomenon. “The emotional and social damage and the devastation linked to drugs and their use is immeasurable.” The ripple of subversive and detrimental consequences from alcoholism, drug addictions, and addictive behavior is appalling. Among the long list of effects is lost productivity, anxiety, depression, increased crime rate, probable incarceration, frequent illness, and premature death. The limitless consequences include the destruction to personal development, relationships, and families (Henderson 1-2). “Understandably, Americans consider drug abuse to be one of the most serious problems” in the fabric of society. And although “addiction is the result of voluntary drug use, addiction is no longer voluntary behavior, it’s uncontrollable behavior,” says Alan Leshner, director of the National Institute on Drug Abuse (Torr 12-13).
In light of the findings of the study, the pharmacokinetic parameters of this drug would v...