Chromatography is a method used to separate the analyte that needs to be studied from the sample. Two phases include in this method that is stationary phase where it does not move and the mobile phase, which is the fluid that transport in the system. In mobile stage, the fluid can be liquid or gas contingent on the types of chromatography being utilized. In chromatography, the sample is first dissolved in the mobile phase before proceeding through the stationary stage. In stationary phase, the analystes are circulated between these both stages where they have distinctive solubilities in each phase. A component which is more soluble in the mobile phase will take shorter time to go through the stationary phase than a component …show more content…
One of these industries is the pharmaceutical industry. This industry develops, makes and markets drugs and pharmaceutical for use as medicines. This diligence has to observe laws and regulation when producing pharmaceutical products by doing testing. One of the most common pharmaceutical products is aspirin production. Aspirin, one of the first drugs to come into common usage, is nevertheless the most widely used in the world – approximately 35,000 metric tonnes are grown and consumed annually, enough to draw over 100 billion standard aspirin tablets every year. Aspirin is a medication that can ease pain and fever, and also help to fight coronary heart disease by avoiding blood …show more content…
The high polarity of the spot will rise quickly compared to the low polarity spot. The plate will be removed with forceps and the solvent front will be marked with a pencil and let the solvent to evaporate completely. Once again examine the plate under the UV light to see the components as dark spots against green-blue or a bright orange background as shown in figure 5. Figure 5 shows the UV visualization Outline the spots with a pencil. By putting the plate in an iodine chamber the spots can be visualized. Compound spots turn brown after a few minutes and then mark the spots after development in iodine vapor because the iodine color fades with time. The value of Rf can be calculated and unknowns components can be identified as shown in figure
electrophoresis. The way the PCR method works is by first mixing a solution containing the
The drug manufacturing industry is concerned with the development, production and marketing of drugs which are to be used as medication. This is one of the oldest industries in the world. The first drug stores date back to the middle Ages. Some of today’s pharmaceutical companies have been founded in the beginning of the previous century. Important discoveries have been made in the early 20th century such as insulin and penicillin who became mass produced. More drugs were developed during the 1950s-1960s such as contraceptives and heart drugs. During that time numerous organizations and declarations were established in order to regulate the industry. Until the 1970s the drug manufacturing industry remained relatively small, and then it began expanding quickly. With the development of technologies and the internet research, manufacturing, marketing and sales of drugs became a lot easier.
Esterification was used to synthesize aspirin which was by reacting salicylic acid with acetic anhydride. To speed up the reaction, dehydrating agent and conc. sulphuric acid was present. The purity of a substance, which is the aspirin in this particular experiment, can be determined by the identification of its melting point.
Most people know Aspirin as a pill to take when they have a headache or some other ailment. There’s much more to Aspirin than most people know about. This report will explain the chemical properties of Aspirin as well as what the uses are, the history of the chemical, and the discovery of the molecule.
The distance of the initial extract line to a pigment band was divided by the distance of the marked solvent front to the initial extract line both were measured in cm. The RF (relative to front) was calculated for each pigment band, indicating the travelled distance between the pigment and the front (solvent line) on the chromatography
Aspirin contains the substance acetylsalicylic acid (ASA), which can relieve inflammation, fever, pain, and known as a “blood thinner”. Aspirin was not officially trademarked until March 6, 1899 when the Imperial Office of Berlin made it official. It has been used for the last 110 years, but its natural form, salicylic acid has been around for thousands by Egyptians, Greeks, and Romans. Aspirin is available in over 80 countries and known as the best non-prescription drug. The most common use of aspirin is to cure headaches and use it as a pain reliever, but aspirin is known to prevent heart attack and strokes. It was first proposed in 1940, but wasn’t confirmed until 1970 when doctors would recommend taking aspirin daily [1].
Chromatography is a method to distinguish between organic and inorganic compounds so that they can be analyzed and examined. By performing analysis of a compound, a scientist can figure out what makes up the compound. Chromatography related techniques have been used for centuries to separate materials such as colorants extracted from plants. However, Chromatography was first developed in 1900 by Russian scientist Michael Tswett. He continued
0,74 0,87 1,00 0,49 100... ... middle of paper ... ... some groups had got different leakage of the pigment in the test tubes with water.
For a drug to get to market it must go through several stages of research and development (Abbott and Vernon). Starting with discovery research, preclinical testing on animals, three phases of clinical trials on humans, and finally FDA (Food and Drug Administration) approval (Abbott and Vernon). Out of several thousands of drugs only a few will make it to the FDA approval stage (Abbott and Vernon). Testing is a highly regulated, time consuming, and expensive process. From beginning to end the process can take fifteen years and less than one of five compounds will make it to market where it is still not guaranteed to succeed (Abbott and
As explained by Saferstein “Chromatography is a means of separating and tentatively identifying the components of a mixtur... ... middle of paper ... ... ively place the suspect or perpetrator behind bars. Analyzing soil compounds can be measured by the levels of organic molecules including n-alkanes, fatty alcohols and fatty acids, which are all found in the waxy outer layer of plant matter (Geddes, 2008). It basically states that compounds can remain in the soil for thousands of years, which explains that each area being tested has its unique organic profile.
Background Information Aspirin is an analgesic (pain relieving) and an antipyretic drug (a drug that lowers body temperature). The main constituent of aspirin is 2 - ethanoythydroxybenzoic acid, also known as acetylsalicyclic acid (shown below right). It was originally made from just salicylic acid (which is found in the bark of a willow tree) when used by the Ancient Greeks to counter fever and pain, but its bitterness and tendency to irritate the stomach caused problems. These were resolved by the German chemist Felix Hoffman, who made the acetyl derivative of salicylic acid in the
Figure 2 also shows that when a solvent is used that is lighter than water, density < 1, the organic phase will be on the top in the separatory funnel, while solvents denser than water, density > 1, will sink to the bottom of the funnel (2). The success of the separatory funnel technique allowed for Thin Layer Chromatography (TLC) and Infrared Spectroscopy (IR) analysis.
The drug industry is a booming business, from legal to illegal drugs it is a multi-billion dollar industry. You hear about drugs everywhere, it is on TV, movies, radio; they are figured in books and magazines. Every so often it an ad will flash across your computer screen, and in daily conversation with friends and co-workers.
HPLC technology works on the principle of conventional chromatography where in there is a stationary phase and a mobile phase. The sample containing the mixture of components is introduced in a column packed
·Aspirin (salicylic acid acetate) is an anti-inflammatory (decreases swelling and inflammation), anti-pyretic (fever reducing), and anti-platelet (decreases platelets in the body to thin blood). Many heart treatment patients take an aspirin a day to prevent blood clotting. However, if aspirin is taken in large quantities over long periods of time, it may cause gastric ulcers or other internal damage. The molecular formula of aspirin is C9H8O4. Some examples of Aspirin are Bayer, Ecotrin, and Aspergum.