STT 11
Abstract
Creutzfeldt-Jakob Disease is an uncommon, deteriorating, consistently fatal brain disorder that is caused by prions. The symptoms of CJD are similar of Alzheimer’s but progress much faster. There are three variations of CJD, sporadic, familial, and acquired. All variations affect the brain the same way and have the same result of death. CJD is an untreatable and incurable disease.
Creutzfeldt-Jakob Disease Imagine watching a family member slip off into a land where they don’t even recognize you or other relatives. Their personality and health rapidly deteriorate to the point of becoming unrecognizable. Within a year, they slip into a coma and eventually die. There is absolutely nothing doctors
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Because CJD is such a rapid progressing disease most patients die within one year of onset. Some of the symptoms associated with CJD are much like Alzheimer’s. “Some common symptoms include depression, agitation, apathy and mood swings, rapidly worsening confusion, disorientation and problems with memory, thinking, planning and judgement, difficulty walking, and muscle stiffness, twitches, and involuntary movements.” (Alzheimer's Association, 2016). Diagnosis of CJD is a controversial issue. The only way to diagnose CJD is by brain biopsy or autopsy. In a brain biopsy, a small piece of tissue is removed and examined by a neuropathologist. This is of course dangerous and not always effective because it is hard to know if the tissue obtained is from the affected part of the brain. Biopsies are usually not recommended, not only because of the risk, but because there is no treatment available that will cure CJD. “There is no treatment that can slow or stop the underlying brain cell destruction caused by Creutzfeldt-Jakob disease and other prion diseases. Various drugs have been tested but have not shown any benefit. Clinical studies of potential CJD treatments are complicated by the rarity of the disease and its rapid progression.” (Alzheimer's Association, 2016). Treatment for CJD is aimed at alleviating symptoms and making the patient as comfortable as possible. “Doctors may prescribe painkillers such as opiates to treat pain if it occurs. Muscle stiffness and twitching may be treated with muscle-relaxing medications or antiseizure drugs. In the later stages of the disease, individuals with CJD become completely dependent on others for their daily needs and comfort.” (Alzheimer's Association,
According to a doctor in the documentary, people are coming to the ICU’s to die. (Lyman et al, 2011) Due to the fact that technology to sustain life is available the decision to end life has become much more complicated yet more people die in hospitals then anywhere else. (Lyman et al, 2011) The story of Marthe the 86 year old dementia patient stood out to me upon viewing the documentary because I recently just had my great grandmother go through the same situation. (Lyman et al, 2011) Marthe entered the ICU and was intubated for two weeks while her family members decided whether to perform a tracheotomy or take her off life support. (Lyman et al, 2011) The family was having a tough time deciding due to the fact that the doctors could sustain Marthe’s life if they requested it. Marthe ended up being taken off the ventilator and to everyone’s surprise was able to breathe but, a day later she could no longer do so and now she has been on life support for a year. (Lyman et al, 2011) Another patient that I took particular interest in was John Moloney a 53 year old multiple myeloma patient who has tried every form of treatment with no success. (Lyman et al, 2011) Despite trying everything he still wanted treatment so he could live and go home with his family but ended up in
However it can also make room for medical, legal and ethical dilemmas. Advances in medical technology enable individuals to delay the inevitable fate of death, overcome cancer, diabetes, and various traumatic injuries. Our advances in medical technologies now allow these individuals to do things on their own terms. The “terminally ill” state is described as having an incurable or irreversible condition that has a high probability of causing death within a relatively short time with or without treatment (Guest, p.3, 1998). A wide range of degenerative diseases can fall into either category, ranging from, HIV/AIDS, Alzheimer’s disease and many forms of cancer. This control, however, lays assistance, whether direct or indirect, from a
All creatures on earth just want to live very long, and the human has more avid than any other creature on our planet. The patients having critical diseases want to prolong their lives, so they want to believe in doctors and modern medical system. I believe that they want to live because they still have a lot of things that they have to do, or they don’t want to make their family feel upset when they pass away. Moreover, their family have too many expectations of the medical treatments and the doctors, but the results are always negative. My close friend’s family is an example. When his grandmother’s diabetes was in the last period, she had to get some surgeries because her feet were gangrenous. After that surgeries, she told she feels very painful and just wants to die, but she does not want to make her family feel bad. Therefore, she had suffered her painful with an expectation prolonging her life on a hospital bed. Many people nearing the end of their lives have to suffer many medical treatments looking like a mortification. “Many people think of CPR as a reliable life save when, in face, the results are usually poor,” written by the author, has demonstrated for that examples. In addition, the doctors are the second factor that affects to the decision using medical treatments. All of the doctors just want to try their best to cure the patients, and they want to help the
Creutzfeldt-Jakob is known as a prion disease. Prion is a protein that occurs normally inside the brain, however
Neurodegeneration is used mainly for diseases that are characterised by progressive loss of structure and function of neurons. There are many neurodegenerative diseases including amyotrophic lateral sclerosis that...
The origin of CWD has yet to be determined (Sigurdson & Aguzzi, 2007). The infection was first noted in 1967 at a captive mule deer research facility. In 1978 pathologists recognized the TSE type brain lesions, also that CWD presented as a prion disease by the neuronal perikaryonic vacuoles, the accumulation of aggregated prion protein and prion infectivity in the brain. In the late 1970s and early 1980s the infection w...
Increasingly, people know from their own experience some painful dilemmas involving elderly or handicapped individuals who are in pain. While the achievements of modern medicine have been used to prolong and enhance life for many, they have also helped create an often dreaded context for dying. Costly technology may keep persons alive, but frequently these persons are cut off from meaningful relationships with others and exist with little or no hope for recovery. Many fearfully imagine a situation at the end of their lives where they or their trusted ones will have no say in decisions about their treatment.
TSEs or more commonly prion diseases are a group of invariably fatal neurodegenerative diseases that occur in humans and animals . This disease is caused by a protease –resistant protein (PrPsc) after misfolding of a host-encoded prion protein (PrP). TSEs can exist as genetic, infectious or sporadic forms. The diseases are characterized by dementia, ataxia and neuropathlogically due to loss of specific neurons in the brain. Other clinical features include persistent painful stimuli, dystonia, visual or cerebellar problems and gliosis (1).
The prion diseases that Chronic Wasting Disease is related to are Creutzfeldt-Jakobs disease found in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapies in sheep (3,4). These diseases are grouped together because they share certain characteristics such as long incubation periods, spongiform changes that are associated with neural loss, and cause failure to induce inflammatory responses (Chronic Wasting Disease Alliance).
Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.
Prion Disease is an illness that many have not heard about. This is sad because many have died and are dying from this disease that doesn’t yet have a cure. “Prion Disease is a group of conditions that affect the nervous system in humans and animals… these conditions impair brain functions, causing changes in memory, personality, and behavior; a decline in intellectual function (dementia); and abnormal movements particularly difficulty with coordinating movements (ataxia)” (Genetics Home Reference). This is basically the definition of what Prion Disease is and without going into depth it explains how it affects the person that is affected. “In t...
Imagine if you loss control of your body but your mind stayed unaffected. You would be a prisoner in your own body, all leading up to your death sentence. That is the sad fate for the people diagnosed with Amyotrophic lateral sclerosis (ALS). “Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder was first described by Ran in 1850. This description was then expanded in 1873 by Charcot, who emphasized the involvement of the corticospinal tracts. In the United States, ALS is often referred to as Lou Gehrig's disease, after the famous ball player who was stricken by the disease in the midst of his career. (Yale School of Medicine, 2014)” In this paper will go through the definition, the process, the signs, the risk factors, etiology, and discus the known people that have suffered with this terminal disease.
...world is telling them to forget the tragically ill and instead bring new life into this world and also deny them of the medical treatments that could possibly save their lives.
Imagine visiting your 85-year-old mother in the hospital after she has a debilitating stroke. You find out that, in order to survive, she requires a feeding tube and antibiotics to fight an infection. She once told you that no matter what happened, she wants to live. But the doctor refuses further life-sustaining treatment. When you ask why, you are told, in effect, "The time has come for your mother to die. All we will provide is comfort care."
‘Being Mortal’ was a fascinating read about a young man who grows in the understanding of death and dying and what matters most in the end. We all have constraints and no matter how well we take care of ourselves and live our life, death comes to us all; and how we meet that end can be very different depending on how we want to spend the last moments of our journey. Medical science has its power and pushes the boundaries of life and death, but it can’t always save you, it won’t always work out the way that you hope it does. Doctors like Atul Gawande struggle to fix everyone’s problem and cure the patients who come into the hospital; but as the book progresses Atul finds that there are ways to handle patients’ lives and it doesn’t always involve