Cortef Research Paper

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Cortef is a specific brand name drug used to treat conditions such as arthritis, blood/hormone/immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies (WebMD, 2016). Cortef is also used to decrease the immune response to various diseases to reduce symptoms such as pain, swelling, and allergic-type reactions. It is therapeutically labeled as an anti-inflammatory and an immunosuppressant. Pharmacologically, it is categorized as a corticosteroid. Cortef works as an agonist within the body as it stimulates and promotes several different functions. The general uses and indications for Cortef are wide and varying. Such conditions for use include: endocrine disorders, collagen disorders, rheumatic disorders, …show more content…

A Cortef drug tablet was first manufactured in December 1952 by Pharmacia and Upjohn manufacturing companies (Drugs.com, 2016). It is currently manufactured by Pfizer Inc. Cortef tablets are manufactured in three strengths: 5mg, 10mg, or 20mg of hydrocortisone. Inactive ingredients include calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose (Pfizer, 2006). There have been approved generic versions of Cortef and they are manufactured by Amedra Pharms, Hikma Intl Pharms, and Vintage (Drugs.com, 2016). The dosage of Cortef depends on the condition and severity of the disease being treated. Administration of Cortef is generally done orally with tablets, but can be administered via the rectum by enema or by intramuscular intravenous. The oral tablets are white and round with the brand name and dose labeled on one side of the tablet. Physicians recommend taking the tablets with milk or food so as not to upset the stomach (WebMD, …show more content…

Withdrawal symptoms may arise if a patient stops medication. Withdrawal symptoms include weakness, weight loss, nausea, muscle pain, tiredness, headache, and dizziness (WebMD, 2016). Use of Cortef does involve side effects. Nausea, heartburn, headache, acne, trouble sleeping, change in menstrual period, or increased sweating may occur (WebMD, 2016). Central nervous system effects may also occur and patients must be monitored closely for depression and/or euphoria as these are the most common. Cortef weakens the body’s immune response; therefore the body’s ability to fight infection is lowered. This is rarely fatal. Allergic reactions are also rare with Cortef. It is undetermined if Cortef has any long lasting effects on pregnant women or their children. Physicians have to weigh out the benefits of usage against potential hazards. Cortef should not be taken if a patient is suffering from a systemic fungal infection, is allergic to any ingredients listed in the drug, or if they are taking mifepristone (Drugs.com,

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