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Educational leadership roles
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This summer, I will be working in a computational chemistry lab, which will allow me to gain a new perspective regarding Chemistry. This opportunity will allow me to explore the mathematical aspect of chemistry and appreciate new concepts. Additionally, I have a variety of attributes that qualify me for the NSERC Undergraduate Student Research Award. For example, I recently began a position as a ‘new student mentor.’ This leadership position allows me to assist students, as well share my personal experiences with individuals, who may be unsure of the possibilities available to them. Tutoring high school students and assisting a student who uses a wheelchair, in undergraduate chemistry labs, allows me to share my knowledge and skills. Beyond the laboratory, I excel in my studies, maintaining a cumulative GPA of 3.92. Overall, being well rounded and excelling at both practical and theoretical components of scientific education are very important to succeeding.
During this past summer, while being funded by the University of Lethbridge’s Chinook Summer Scholarship, I had the opportunity of working in a biochemistry lab. My primary focus was on RNA modifications in the peptidyl transferase center of the ribosome, specifically psedouridines. Throughout this research position, I was able to present my work at the
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The project focuses on the interaction of factors, such as metal ions, hydrogen bonding interactions, and base stacking on glycosidic bond cleavage in RNA. Using computational methods, I aim at studying the previous aspects mentioned and their impact on the degycosylation reaction. As I have already learned the basic computational methods for determining parameters of simple structures, I will be able to expand my computational skills as well as incorporate theory from my classes into the
Miller, Kenneth R. and Joseph S. Levine. “Chapter 12: DNA and RNA.” Biology. Upper Saddle River: Pearson Education, Inc., 2002. Print.
The study of nucleic acids has now become a fruitful and dynamic scientific enterprise. Nucleic acids are of unique importance in biological systems. Genes are made up of deoxyribonucleic acid or DNA, and each gene is a linear segment, or polymer, of a long DNA molecule. A DNA polymer, or DNA oligonucleotide, contains a linear arrangement of subunits called nucleotides. There are four types of nucleotides. Each nucleotide has three components; a phosphate group, a sugar and a base that contains nitrogen within its structure. The sugar moiety in DNA oligonucleotides is always dexoyribose, and there are four alternative bases: adenine (A), thymine (T), guanine (G), and cytosine (C). The phosphate groups and the deoxyribose sugars form the backbone of each DNA stand. The bases are joined to the deoxyribose sugar and stick out to the side. Both oligomers, DNA and RNA, consist of 5’->3’ phosphodiester-linked nucleotide units that are composed of a 2’-deoxy-D-ribose (DNA) or D-ribose (RNA) in their furanose forms and a heteroaromatic nucleobase (A, T, G, and C; A, U, G, C), and the resulting oligonucleotide chain is composed of a polar, negatively charged sugar-phosphate backbone and an array of hydrophobic nucleobases. The amphiphilic nature of these polymers dictates the assembly and maintenance of secondary and tertiary structures the oligonucleotides can form. In the DNA duplex structure, genetic information is stored as a linear nucleotide code. This code can be accessed and replicated. RNA, or ribonucleic acid, is another structurally related essential biopolymer. RNA differs from DNA in having the sugar ribose in place of the deoxyribos...
Hall, Linley Erin. “Understanding Genetics DNA and RNA.” New York: The Rosen Publishing Group, Inc., 2011. Print. 01 Apr. 2014.
... This observation gives evidence to the idea that polymerization of LC domains should precede their binding to CTD of RNA polymerase II.
After the initiation process is complete, amino acids begin to be added to the polypeptide in a three step process known as elongation. First, the mRNA codon in the A site pairs with the anticodon of an incoming tRNA molecule. Next, the polypeptide separates from the tRNA in the P site and attaches to the amino acid that was carried by the tRNA in the A site. The ribosome catalyzes formation of the bond. Finally, the P site tRNA leaves the ribosome and the ribosome moves the tRNA in the A site to the P site with its attached polypeptide. A new tRNA is then able to bind to the A site to start the elongation process over again. Eventually, a stop codon will reach the A site signaling the amino acid to stop translation
Other than the proximity, Lehigh brings an opportunity to study chemistry. With over 70% of students participating in research, I hope to assist the faculty in contributing and making an impact towards the field of science. I can also pave my chemistry concentration with the flexibility that will allow me to focus on my future career in health. With the programs flexibility, I will be able to form a medical background that will benefit me towards my medical school aspirations.
The day before an Organic Chemistry II exam, I felt worried and unprepared as I wrapped up my office hours as an undergraduate teaching assistant (UTA) for CompSci 101. As I sat in the room waiting for my replacement to relieve me, I felt myself being pulled in all directions. At the end of the previous semester, I had ambitiously enrolled myself in two upper-level computer science courses, an infamously difficult statistics course, and second semester organic chemistry. Back then, I had not anticipated that I would have the opportunity to write my own book the following school year or that my manuscripts would be expected in the following
Nogales’s research is centered on two main projects at the moment. Her lab is funded by an NCI project that focuses on the structural biology of DNA repair. The first project deals with the regulation of gene expression and the central dogma of biology. She studies nucleic acid transaction and hopes to go beyond the architecture of molecules used to regulate gene expression by describing conformal landscapes and linking structures to actual functions involved in the expressions of genes and characteristics in organisms. In order to do such research, Nogales and her team focus on elements like eukaryotic DNA replication, eukaryotic transcription, eukaryotic translation initiation, and coupled DNA
Once the DNA is unwinded, only one strand will serve as the template for the process of transcription. Transcription is the process of forming messenger RNA from the bacterial DNA strand. The enzyme RNA polymerase will connect complementary RNA bases to the DNA template strand. These RNA bases are bonded together to form a single stranded mRNA. Therefore this mRNA molecule contains a template based on the DNA.
The N-terminal domain aids in formation of the dimer and anchoring the protein to the ribosomes whereas the C-terminal domain binds to EF-Tu in the ternary complex (Savelsbergh et al., 2000). Figure 11 -. L7/L12. The 50S subunit rRNA is depicted in gray and the 50S r-proteins are shown in cyan. The L12 dimers are shown in red with their CTD, NTD and the hinge region. The L10 that provides flexibility is shown in blue, while the L11 acting as an anchor is shown in yellow.
I, Gujjula Teja Reddy, have secured my admission in Ontario College Diploma in Chemical Laboratory Technician Program at Seneca College. Being a student from health Science’s background, I am always fascinated by the application of Chemistry in our day to day life and realized that Chemistry is a vast subject that benefits the entire community and society at large. I want to help in betterment of people s life by the application of valuable knowledge gained from the subject. EDUCATION: I have excelled in academic in every step of my education.
The actual formation of the polypeptide chain occurs only with the assistance of tRNA which brings single amino acids to the mRNA, beginning with methionine (coded AUG). The first tRNA binds at the P-site, but when the A site is occupied by the subsequent tRNA molecule, the original amino acid moves over to the second tRNA.
Ribozymes are catalytic molecules that cleave the ribonucleic acid (RNA) at specific sequences (Gesteland et al. 2006). RNA is the nucleic acid that is made in the process of transcription; when the deoxyribonucleic acid (DNA) anneals, it transcribes itself into a linear stranded molecule called RNA. In order for RNA to synthesise proteins, it requires catalytic enzymes to perform certain chemical reactions. In the past, it was thought that all chemical reactions are catalysed by protein enzymes; however, in the eighties this hypothesis was disproved as Thomas Cech and Sydney Altman discovered that RNA is able to carry out self-catalysing activities which were named as ribozymes because they perform similar functions as the protein enzymes (Jaeger, 1997). Even though, RNA ribozymes lack the functional groups diversity found in protein enzymes, they are able to carry out their own catalytic reactions due to their tendency to fold into a 3D structure and form helices by Watson-Crick base pairing role (Kiehntopf et al. 1995). Ribozymes are now play critical role in the understanding of biochemistry, as they have the ability to catalyse some of the most important chemical reactions such as RNA splicing as well as the synthesis of peptides, for instance ribozymes can speed up the phosphoryl transfer chemical reactions by 1011 folds. This review will describe the structure, sources and applications of ribozymes.
As a Biochemistry major, I started off this class certain that the information that I was yet to learn would not apply to me. I originally took this class because I had a positive experience in my AP Psychology course in high school. I also wanted to explore the psychology major however, I was surprised to learn that the pay after obtaining a bachelor’s degree in psychology is not realistically high. After learning about the psychology major, I have decided to change my major. I am not interested in pursuing a psychology major for the pay, but to improve my knowledge on the human mind to make me a qualified physician.
Prior to coming to Lehigh university, I spend two years at Lehigh Carbon Community College (LCCC) were I took some general college courses and fulfilled most of my college humanity and social science course work. Two of the most memorable courses I took at LCCC were microbiology and Anatomy and physiology. Not to say the other courses were not quite as interesting but the point is, it was the first time I got to do some quality lab works in college. I remember during our microbiology lab, our project for that semester was to test how effective different growth media were on different bacteria cultures as well as staining the bacteria to determine if they were Gram positive or negative. Oh how interesting that was, each week I looked forward to that lab as well as the